A5066280744- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Advanced Glycation End Products research
- Alcohol Consumption and Health Effects
- Bone and Dental Protein Studies
- Ferroptosis and cancer prognosis
- Organ Donation and Transplantation
- Immune Cell Function and Interaction
- Hepatitis C virus research
- PI3K/AKT/mTOR signaling in cancer
- Clinical Nutrition and Gastroenterology
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Lipids, and Metabolism
- Digestive system and related health
- Hippo pathway signaling and YAP/TAZ
- MicroRNA in disease regulation
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
Tianjin First Center Hospital
2012-2025
Tianjin Medical University
2012-2025
Nankai University
2021-2025
University of Illinois Chicago
2020-2024
Tianjin University
2019-2024
Hebei Normal University
2024
Southwest Jiaotong University
2023
University Hospital of Zurich
2015-2022
University of Zurich
2022
University of Illinois at Springfield
2022
Background & AimsNonalcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, hepatocyte ballooning degeneration, and fibrosis, all of which increase the risk progression to end-stage liver disease. Osteopontin (OPN, SPP1) plays an important role in macrophage (MF) biology, but whether MF-derived OPN affects NASH unknown.MethodsWe analyzed publicly available transcriptomic datasets from patients with NASH, used mice conditional overexpression or ablation Spp1...
Background and Aims: HCC, the third leading cause of cancer-related death, arises in context liver fibrosis. Although HCC is generally poorly fibrogenic, some tumors harbor focal intratumor extracellular matrix (ECM) deposits called “fibrous nests.” To date, molecular composition clinical relevance these ECM have not been fully defined. Approach Results: We performed quantitative matrisome analysis by tandem mass tags spectrometry 20 human cancer specific (HCCs) with high or low-grade...
To assess whether radiomics signature can identify aggressive behavior and predict recurrence of hepatocellular carcinoma (HCC) after liver transplantation.Our study consisted a training dataset (n = 93) validation (40) with clinically confirmed HCC transplantation from October 2011 to December 2016. Radiomics features were extracted by delineating regions-of-interest (ROIs) around the lesion in four phases CT images. A was generated using least absolute shrinkage selection operator (LASSO)...
Abstract Neutrophils are associated with pro‐inflammation and contribute to pathophysiology of ischemic stroke. Prevention neutrophils from infiltrating into area can be a potential approach for stroke therapy. In this study, rod‐shaped polylactic acid polyglycolic (PLGA) nanoparticles encapsulated piceatannol is developed target intervene the interaction inflamed endothelial cells. contrast macrophages, exhibit enhanced endocytosis elongated particles. The aspect ratio (AR) 5 display higher...
The incidence of graft fibrosis is elevated following pediatric liver transplantation (pLT) and influenced by cold ischemic time (CIT). Myosin light chain 9 (MYL9), a member the myosin family, could act on hepatic stellate cells (HSCs) induce transition to active phase. We hypothesized that injury stimulate MYL9 expression lead fibrosis. tested hypothesis analyzing multi-omics data from human protocol biopsy samples 2 years after transplant, performing rat LT with different CIT conducting in...
Defective regeneration of small-for-size (SFS) liver remnants and partial grafts remains a key limiting factor in the application surgery transplantation. Exogenous melatonin (MLT) has protective effects on hepatic ischemia-reperfusion injury (IRI), but its influence graft is unknown. The aim study to investigate role MLT IRI settings We established three mouse models associated with transplantation: (I) IR+PH group: 60 minutes ischemia (IR) plus 2/3 hepatectomy (PH); (II) IR+exPH IR...
Background & AimsThe gut-liver axis plays a key role in the pathogenesis of alcohol-associated liver disease (ALD). We demonstrated that Opn-/- develop worse ALD than wild-type (WT) mice; however, intestinal osteopontin (OPN) remains unknown. hypothesized overexpression OPN epithelial cells (IECs) could ameliorate by preserving gut microbiome and barrier function.MethodsOpnKI IEC, OpnΔIEC, WT mice were fed control or ethanol Lieber-DeCarli diet for 6 weeks.ResultsOpnKI IEC but not OpnΔIEC...
Background. Optimizing the immunosuppressive regimen is essential to improve long-term outcomes of pediatric liver transplant recipients. Methods. We conducted a prospective, randomized, open-label study compare safety and efficacy 2 treatment approaches during transplantation: tacrolimus monotherapy following basiliximab induction (the group) dual plus steroids control group). A total 150 patients were enrolled, with 75 allocated each group. Results. In both groups, recipients achieved...
Adipose tissue‑derived mesenchymal stem cells (ADSCs) have been considered to be attractive and readily available adult cells, they are becoming increasingly popular for use in regenerative cell therapy, as accessible through minimally invasive techniques. The present study investigated whether autologous ADSC transplantation promoted liver regeneration following a repeat partial hepatectomy rats. rats were divided into three groups follows: 70% (PH) group; PH (R‑PH) group R‑PH/ADSC group,...
Capecitabine (CAP) is now widely used in the comprehensive treatment of digestive system tumors. Some clinical observations have shown that CAP may immunosuppressive effects, but there still a lack clear experimental verification. In this study, different doses were administered to normal mice by gavage. Our results confirmed did not cause myelosuppression bone marrow tissue; selectively reduced proportion T cells and concentration related pro-inflammatory cytokines, while it increased...
Capecitabine (CAP) is a classic antimetabolic drug and has shown potential antirejection effects after liver transplantation (LT) in clinical studies. Our previous study showed that metronomic CAP can cause the programmed death of T cells by inducing oxidative stress healthy mice. Ferroptosis, newly defined non-apoptotic cell occurs response to iron overload lethal levels lipid peroxidation, an important mechanism which induces death. Therefore, ferroptosis may also play role CAP-induced...
Background and Aims: Early allograft dysfunction (EAD) is a severe event leading to graft failure after liver transplant (LT). Extracellular high-mobility group box-1 (HMGB1) damage-associated molecular pattern that contributes hepatic ischemia-reperfusion injury (IRI). However, the contribution of intracellular HMGB1 LT remains elusive. We hypothesized neutrophil-derived from recipients protects post-LT EAD. Approach Results: generated mice with conditional ablation or overexpression Hmgb1...
The ability of the liver to restore its original volume following tissue loss has been associated with Hippo-YAP1 pathway, a key controller organ size. Yes-associated protein 1 (YAP1)—a growth effector usually restrained by Hippo signaling—is believed be particular importance; however, role in regeneration remains ill-defined. To explore function, we knocked down YAP1 prior standard 70%-hepatectomy (sHx) using hepatocyte-specific nanoformulation. Knockdown was effective during major...
Chronic hepatitis B virus (HBV) infection changes the composition of extracellular matrix (ECM) and enables onset progression hepatocellular carcinoma (HCC). The ensemble ECM proteins associated factors is a major component tumor microenvironment. Our aim was to unveil matrisome genes from HBV-related HCC. Transcriptomic clinical profiles 444 patients with HCC were retrieved Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) repositories. Matrisome hepatocarcinogenesis, gene modules,...
Background & Aims: Excessive deposition and crosslinking of extracellular matrix increases liver density stiffness, promotes fibrogenesis, resistance to fibrinolysis. An emerging therapeutic opportunity in fibrosis is target the composition or block pathogenic communication with surrounding cells. However, type extent changes triggering depend on underlying etiology. Our aim was unveil matrisome genes not dependent etiology, which are clinically relevant fibrosis. Approach Results: We...
The lack of age- and size-matched organs result in higher waiting list mortality pediatric recipients than adults. Organs from deceased newborns infants are a valuable source to increase donor pool liver transplantation. However, the feasibility safety using neonatal donors have not been well evaluated.From 2014 2016, 48 transplantations with age younger 1 year old our center were enrolled this study. divided into three groups based on (<1 month, month ≤ <3 months, 3 months <1 year)....