A5034789424- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Intraperitoneal and Appendiceal Malignancies
- Gastric Cancer Management and Outcomes
- Hernia repair and management
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Appendicitis Diagnosis and Management
- Esophageal Cancer Research and Treatment
- Liver physiology and pathology
- Pancreatitis Pathology and Treatment
- Transplantation: Methods and Outcomes
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Scientific Computing and Data Management
University Hospital of Zurich
2014-2024
University of Zurich
2015-2024
Spital Muri
2023
ETH Zurich
2021-2022
Objective: The aim of this study was to determine the predictive value machine perfusate analysis on graft outcome. Background: Ex situ perfusion (MP) is gaining increasing interest potentially repair injured organs and assess organ function. In field liver transplantation, however, no studies exist reliable prediction function during MP. Methods: We have used hypothermic oxygenated (HOPE) for donation after circulatory death (DCD) or extended criteria brain (DBD) human grafts last 7 years....
Objective: The aim of this study was to maintain long-term full function and viability partial livers perfused ex situ for sufficient duration enable treatment, repair, regeneration. Background: Organ shortage remains the single most important factor limiting success transplantation. Autotransplantation in patients with nonresectable liver tumors is rarely feasible due insufficient tumor-free remnant tissue. This limitation could be solved by availability preservation that enables functional...
Abstract Background The optimal treatment in patients with gastric cancer and peritoneal disease remains controversial. Some guidelines indicate palliative only, while others consider surgical case of positive lavage cytology (CY+) or limited disease. Here, we analyzed the role cancer, prognostic relevance response to neoadjuvant therapy. Methods In this retrospective cohort analysis, adenocarcinoma stomach esophago-gastric junction from a single center operated between 2011 2019. According...
Artificial intelligence (AI) is becoming more useful as a decision-making and outcomes predictor tool. We have developed AI models to predict surgical complexity the postoperative course in laparoscopic liver surgery for segments 7 8.
Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help modify treatment. In patients with gastric esophagogastric junction (AEG) cancer, the accuracy of FDG PET-CT predict pathologic after currently not known. From consecutive cohort 72 patients, 44 resectable, locally-advanced or AEG Siewert type II III received neoCTX primary staging endoscopic ultrasound, laparoscopy. Overall, 14 did show uptake, remaining 30...
In patients with neuroendocrine liver metastasis (NELM), transplantation (LT) is an alternative to resection (LR), although the choice of therapy remains controversial. this multicenter study, we aim provide novel insight in dispute.Following a systematic literature search, 15 large international centers were contacted comprehensive data on their after LR or LT for NELM. Survival analyses performed Kaplan-Meier method, while multivariable Cox regression served identify factors influencing...
Abstract Introduction The use of normothermic liver machine perfusion to repair injured grafts ex situ is an emerging topic clinical importance. However, a major concern the possibility microbial contamination in absence fully functional immune system. Here, we report standardized approach maintain sterility during porcine livers for one week. Methods Porcine (n = 42) were procured and perfused with blood at 34°C following aseptic technique standard operating procedures. antimicrobial...
The purpose of this study was to evaluate the diagnostic performance magnetization transfer (MT) imaging and multigradient echo magnetic resonance (MRI) quantify pancreatic fibrosis lipomatosis in patients before pancreatoduodenectomy for postoperative risk stratification with histopathology as reference standard.Twenty-four (age, 68 ± 8 years, 16 males) prospectively underwent quantitative MT using a 2-dimensional gradient sequence without prepulse on 3 T MRI 1 day due adenocarcinoma head...
Multicentre clinical trials are challenged by high administrative burden, data management pitfalls and costs. This leads to a reduced enthusiasm commitment of the physicians involved thus reluctance in conducting multicentre trials.The purpose this study was develop web-based open source platform support multi-centre trial.We developed on Drupal, an software distributed under terms General Public License, web-based, trial system with design science research approach.This evaluated...