A5009910426- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Cancer Cells and Metastasis
- Blood transfusion and management
- Hepatitis B Virus Studies
- Transplantation: Methods and Outcomes
- Blood donation and transfusion practices
- Neuroendocrine Tumor Research Advances
- Pharmacological Effects and Toxicity Studies
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Liver physiology and pathology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pediatric Hepatobiliary Diseases and Treatments
- Organ and Tissue Transplantation Research
University of Southern California
2015-2024
Keck Hospital of USC
2005-2024
Southern California University for Professional Studies
2008-2023
Scripps Institution of Oceanography
2022
University of California, San Diego
2022
LAC+USC Medical Center
2002-2015
Queen Elizabeth Hospital Birmingham
2007
Emmes (United States)
2007
King's College London
2006
Children's Hospital of Los Angeles
2005
The detection of tumor-derived cell-free DNA in plasma is one the most promising directions cancer diagnosis. major challenge such an approach how to identify tiny amount tumor DNAs out total blood. Here we propose ultrasensitive method, termed 'CancerDetector', using methylation profiles DNAs. key our method probabilistically model joint states multiple adjacent CpG sites on individual sequencing read, order exploit pervasive nature for signal amplification. Therefore, CancerDetector can...
To compare conventional low-temperature storage of transplant donor livers [static cold (SCS)] with the organs at physiological body temperature [normothermic machine perfusion (NMP)].
Objective To test the safety and efficacy of a bioartificial liver support system in patients with severe acute failure. Summary Background Data authors developed using porcine hepatocytes. The was tested vitro shown to have differentiated functions (cytochrome P450 activity, synthesis liver-specific proteins, bilirubin synthesis, conjugation). When vivo experimental animals failure, it gave substantial metabolic hemodynamic support. Methods Seven failure received double lumen catheter...
Tumor-initiating stem-like cells (TICs) are resistant to chemotherapy and associated with hepatocellular carcinoma (HCC) caused by HCV and/or alcohol-related chronic liver injury. Using Tg mouse models patients HCC, we isolated CD133(+) TICs identified the pluripotency marker NANOG as a direct target of TLR4, which drives tumor-initiating activity TICs. These TLR4/NANOG-dependent were defective in TGF-β tumor suppressor pathway. Functional oncogene screening TIC cDNA library Yap1 Igf2bp3...
Severe alcoholic hepatitis (sAH) is associated with a poor prognosis. There no proven effective treatment for sAH, which why early transplantation has been increasingly discussed. Hepatoblastoma-derived C3A cells express anti-inflammatory proteins and growth factors were tested in an extracorporeal cellular therapy (ELAD) study to establish their effect on survival subjects sAH. Adults bilirubin ≥8 mg/dL, Maddrey's discriminant function ≥ 32, Model End-Stage Liver Disease (MELD) score ≤ 35...
A 26-year-old female patient with fulminant hepatic failure and a history of autoimmune hepatitis was heterotopically transplanted pig xenograft to provide temporary metabolic support prior transplantation human donor organ. Circulating natural antipig antibodies were removed by plasmapheresis ex vivo en bloc perfusion the kidneys. The liver functioned after as measured active bile production, stabilization prothrombin levels, reduction in circulating levels lactic acid enzymes AST ALT....
This randomized, prospective, multicenter trial compared the safety and efficacy of steroid-free immunosuppression (IS) to 2 standard IS regimens in patients undergoing transplantation for hepatitis C virus (HCV) infection. The outcome measures were acute cellular rejection (ACR), severe HCV recurrence, survival. randomized (1:1:2) tacrolimus (TAC) corticosteroids (arm 1; n = 77), mycophenolate mofetil (MMF), TAC, 2; 72), or MMF, daclizumab induction with no 3; 146). In all, 295 RNA-positive...
Mycophenolate mofetil (MMF) and sirolimus (SRL) have been used for calcineurin inhibitor (CNI) minimization to reduce nephrotoxicity following liver transplantation. In this prospective, open-label, multicenter study, patients undergoing transplantation from July 2005 June 2007 who were maintained on MMF/CNI randomized 4 12 weeks after receive MMF/SRL (n = 148) or continue 145) included in the intent-to-treat population. The primary efficacy endpoints mean percentage change calculated...
Drug resistance is a major problem in the treatment of liver cancer. Mammalian Target Rapamycin 1 (mTORC1) inhibitors have been tested for cancer based on hyperactive mTOR this malignancy. However, their clinical trials showed poor outcome, most likely due to ability upregulate CD133 and promote chemoresistance. The + tumor–initiating stem cell–like cells (TICs) isolated from mouse human tumors are chemoresistant, identification an approach abrogate desired. In search compound that rescinds...
Allograft rejection is common following clinical organ transplantation, but defining specific immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose escalation, corticosteroids, and/or lymphocyte depleting antibodies have remained the primary options for treatment of episodes. Here, we developed a highly multiplexed imaging mass cytometry panel to study response in archival biopsies from 79 liver transplant (LT) recipients with either no (NR), acute T...
Background. A study was performed by 17 different U.S. liver transplantation centers to determine the safety and efficacy of conversion from cyclosporine tacrolimus for chronic allograft rejection. Methods. Ninety-one patients were converted a mean 319 days after transplantation. The indication ongoing rejection confirmed biochemical histologic criteria. Patients followed 251 until end study. Results. Sixty-four (70.3%) alive with their initial hepatic at conclusion period defined as...