A5018146949- Oral microbiology and periodontitis research
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Bone health and treatments
- Urological Disorders and Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Teratomas and Epidermoid Cysts
- Cancer, Hypoxia, and Metabolism
- Moyamoya disease diagnosis and treatment
- Urinary Tract Infections Management
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Kidney Stones and Urolithiasis Treatments
- Medical Imaging Techniques and Applications
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Pelvic floor disorders treatments
- Salivary Gland Disorders and Functions
- Urinary Bladder and Prostate Research
- Bone health and osteoporosis research
University of Southern California
2020-2023
Takasaki University of Health and Welfare
2018
Okayama University
2013-2017
Kanto Central Hospital
2002-2013
NTT Medical Center
2006-2012
The University of Tokyo
1987-2010
Tokyo Teishin Hospital
1996
The aim of this study was to examine whether salivary exosomal miRNAs could be identified as aging biomarkers. Fifteen young healthy volunteers (median age, 21.0 years) and 13 old individuals 66.0 were recruited. Unstimulated whole saliva collected, exosomes isolated, total RNA extracted. In a microarray, 242 commonly detected in these two mixed samples. Based on the cut-off values 2- or 0.5-fold changes (FC) regulatory power for process, six candidate (miR-24-3p, miR-371a-5p, miR-3175,...
<h3>SUMMARY:</h3> IgG4-related IPTs have been reported in various sites and may form part of the spectrum systemic sclerosing disease. Some pseudotumors are clinically radiologically indistinguishable from malignant tumors. We present first case an IPT trigeminal nerve diagnosed histopathologically without involvement any common sites. The pseudotumor represent a component
Using superselective catheterization technique, venous sampling directly from the cavernous sinus was performed in seven patients with Cushing's disease and one patient ectopic ACTH secreting tumor. In central/peripheral (c/p) gradients of (11.9-111.1; mean, 49.6) were much greater than those inferior petrosal (1.0-52.0; 14.0). The intercavernous provided correct lateralization all but who had a midline A tumor showed no both sinus. c/p PRL smaller sinus, jugular vein. essentially indicated...
Studies demonstrated that periodontitis modulates microRNA (miRNAs) expression rates in periodontal tissue. However, the relationship between and miRNAs profile circulation remains unclear. In this study, we investigated effects of on serum a rat model.Male Wistar rats (n = 32, 8 weeks old) were divided into four groups eight each. The control received no treatment for 2 or 4 weeks. other two groups, was ligature induced Serum profiles each group compared.Ligation around teeth inflammation...
Tumor-initiating stem-like cells (TICs) are defective in maintaining asymmetric cell division and responsible for tumor recurrence. Cell-fate-determinant molecule NUMB-interacting protein (TBC1D15) is overexpressed contributes to p53 degradation TICs. Here we identify TBC1D15-mediated oncogenic mechanisms tested the tumorigenic roles of TBC1D15 vivo. We examined hepatocellular carcinoma (HCC) development alcohol Western diet-fed hepatitis C virus NS5A Tg mice with hepatocyte-specific...
Abstract RNA-binding protein Musashi 2 (MSI2) is elevated in several cancers and linked to poor prognosis. Here, we tested if MSI2 promotes MYC viral mRNA translation induce self-renewal via an internal ribosome entry sequence (IRES). We performed RIP-seq using anti-MSI2 antibody tumor-initiating stem-like cells (TICs). binds the site (IRES)-containing oncogene mRNAs including MYC, JUN VEGFA as well HCV IRES increase their synthesis promote tumor-initiation at post-transcriptional level. a...
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide expressed in the central nervous system and peripheral organs. Previous studies revealed role distribution of PACAP rodent testis, however, its presence human testis testicular germ cell tumors not known. We used RT-PCR immunohistological observations to investigate whether tissue contain PACAP. The mRNAs for receptors were detected total RNA extracted from testes. immunoreactivity was observed spermatogonia spermatids...
This cross-sectional study addressed the relationship between coffee consumption and periodontitis in patients during maintenance phase of periodontal treatment. A total 414 treatment completed a questionnaire including items related to intake underwent examination. Logistic regression analysis showed that presence moderate/severe was correlated with hypertension (Odds Ratio (OR) = 1.99, p < 0.05), smoking (former, OR 5.63, 0.01; current, 6.81, 0.076), number teeth present (OR 0.89, 0.001),...
Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect hydrogen-rich water may attenuate stress and prevent resorption cases obesity. We examined whether could suppress obese rats fed a high-fat diet. Male Fischer 344 (n = 18) were divided into three groups six each: control group (fed regular diet drinking distilled water) two experimental or water). level 8-hydroxydeoxyguanosine was determined to evaluate stress....
Androgen-deprivation therapy for prostate cancer decreases bone mineral density and increases the risk of fracture. The effect risedronate, a potent third-generation oral bisphosphonate, on loss during androgen deprivation was investigated.Sixty-one patients with mean age (+/- SD) 79 +/- 6 years who had received 42 29 months were enrolled, treated 2.5 mg risedronate daily six months. Bone measured at femoral neck, lumbar spine, ultradistal radius by dual energy X-ray absorptiometry. percent...
Retrieval of remote memory is considered to differentially involve the anterior and posterior temporal neocortices. Previous neuropsychological studies suggest that different cortical regions are involved in retrieval categories stimuli, whereas region more generally retrieval. In present study, using functional magnetic resonance imaging human brains, we tested this dissociation by examining precise characteristics regions. Two faces scenes, were used for paired stimuli be retrieved, brain...
A critical barrier to effective cancer therapy is the improvement of drug selectivity, toxicity, and reduced recurrence tumors expanded from tumor-initiating stem-like cells (TICs). The aim identify circulating tumor cell (CTC)-biomarkers an combination TIC-specific, repurposed federal administration (FDA)-approved drugs. Three different types high-throughput screens targeting TIC population are employed: these include a CD133 (+) viability screen, NANOG expression screen. When combined in...
Oxidative stress is associated with age-related reactions. The anti-oxidative effects of a reduced form co-enzyme Q10 (rCoQ10) suppress oxidative stress, which may contribute to the prevention inflammatory We examined topically applied rCoQ10 on periodontal reactions in rat aging model. Male Fischer 344 rats, 2 (n = 6) and 4 mos 18) age, were used. All two-month-old rats 6 four-month-old sacrificed 12 remaining received ointment or without 1% gingival surface until they reached age. showed...
Recent advancement of resting-state functional connectivity magnetic resonance imaging (MRI) has provided a method for drawing boundaries brain areas. However, it remains to be elucidated how the parcellated areas in association cortex relate spatial extent activation which ought reflect unit neural network supporting that particular function. To address this issue, present study, we first mapped and 2 adjacent activations human inferior frontal cortex, then examined relationship between...
Metabolic syndrome is associated with obesity, insulin resistance, and the risk of cancer. We tested whether oncogenic transcription factor c-JUN metabolically reprogrammed cells to induce obesity cancer by reduction glucose uptake, promotion stemness phenotype leading malignant transformation. Liquid alcohol, high-cholesterol, fat diet (HCFD), isocaloric dextrin were fed wild-type or experimental mice for 12 months promote hepatocellular carcinoma (HCC). demonstrated 40% developed liver...
Objective. Buccal mucosa ridging (BMR) is known as a clinical sign of clenching, which one the major manifestations bruxism. However, there are few reports about formation BMR and no data regarding association between factors such malocclusion. The purpose current study was to investigate relationship number teeth present, gender, body mass index (BMI), occlusion clenching habit in university students. Materials methods. A total 2101 students (1164 males, 937 females), aged 18–29 years old,...
Aim . The present cohort study describes the longitudinal relationship between plasma oxidative status and periodontitis progression during maintenance phase of treatment. Materials Methods Forty-five patients (mean age 58.8 years) were monitored from 2008 to 2013. Periodontal conditions, including probing pocket depth (PPD) clinical attachment level (CAL), recorded. Measurements reactive oxygen metabolites (ROM) biologic antioxidant potential (BAP) performed evaluate status. assigned into 2...