Colleen F. Kelley
A5082479644- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- Sex work and related issues
- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- SARS-CoV-2 detection and testing
- Syphilis Diagnosis and Treatment
- Immune Cell Function and Interaction
- COVID-19 epidemiological studies
- Asthma and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- Respiratory Support and Mechanisms
- LGBTQ Health, Identity, and Policy
- Animal Virus Infections Studies
- Poxvirus research and outbreaks
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Dermatology and Skin Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
Emory University
2016-2025
Grady Memorial Hospital
2004-2025
Grady Health System
2019-2025
Infectious Diseases Society of America
2025
Association Clinique et Thérapeutique Infantile du Val de Marne
2024
HOPE Clinic
2016-2024
University of Washington
2024
University of California, San Francisco
2024
San Francisco General Hospital
2007-2024
Christ University
2024
In the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed for neutralizing and binding antibodies as correlates of risk COVID-19 disease protection. These immune markers measured at time second vaccination 4 weeks later, with values reported in standardized World Health Organization international units. All inversely associated directly efficacy. Vaccine postvaccination 50% neutralization titers 10, 100, 1000 had estimated efficacies 78% (95% confidence...
Safe and effective long-acting injectable agents for preexposure prophylaxis (PrEP) human immunodeficiency virus (HIV) infection are needed to increase the options preventing HIV infection.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish vaccine-induced protective immune responses, particularly as antibody titers wane over time. Here, we assess the effect of SARS-CoV-2 variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.429 (Epsilon), B.1.526 (Iota), and B.1.617.2 (Delta) on binding, neutralizing, angiotensin-converting enzyme (ACE2)–competing antibodies elicited by messenger RNA (mRNA) vaccine mRNA-1273 7 months. Cross-reactive...
Although antiretroviral therapy has the ability to fully restore a normal CD4(+) cell count (>500 cells/mm(3)) in most patients, it is not yet clear whether all patients can achieve normalization of their count, part because no study followed up for >7 years.Three hundred sixty-six from 5 clinical cohorts who maintained plasma human immunodeficiency virus (HIV) RNA level 1000 copies/mL at least 4 years after initiation were included. Changes evaluated using mixed-effects modeling,...
The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane envelope structural proteins.We did phase 1, randomised, open-label trials involving healthy adult volunteers. VRC 319 trial, done in three centres, plasmid VRC5288 (Zika Japanese encephalitis chimera), the 320, one centre, VRC5283 (wild-type virus). Eligible participants were aged 18-35 years VRC19 18-50 320. Participants randomly...
Background The reasons for black/white disparities in HIV epidemics among men who have sex with puzzled researchers decades. Understanding these requires looking beyond individual-level behavioral risk to a more comprehensive framework. Methods and Findings From July 2010-Decemeber 2012, 803 (454 black, 349 white) were recruited through venue-based online sampling; consenting provided STI testing, completed survey partner inventory, place of residence geocoding. prevalence was higher black...
Coronavirus disease 2019 (COVID-19) vaccines have begun to be distributed across the United States and offered initially priority groups including health care personnel persons living in long-term facilities. Guidance regarding whether pregnant should receive a COVID-19 vaccine is needed. Because were excluded from initial phase 3 clinical trials of vaccines, limited data are available on their efficacy safety during pregnancy. After developmental reproductive toxicology studies completed,...
Abstract Background In the Coronavirus Efficacy (COVE) trial, estimated mRNA-1273 vaccine efficacy against coronavirus disease-19 (COVID-19) was 94%. SARS-CoV-2 antibody measurements were assessed as correlates of COVID-19 risk and protection. Methods Through case-cohort sampling, participants selected for measurement four serum markers at Day 1 (first dose), 29 (second 57: IgG binding antibodies (bAbs) to Spike, bAbs Spike receptor-binding domain (RBD), 50% 80% inhibitory dilution...
BackgroundTwice-yearly subcutaneous lenacapavir has been shown to be efficacious for prevention of HIV infection in cisgender women. The efficacy preexposure prophylaxis (PrEP) men, transgender women, and gender-nonbinary persons is unclear.MethodsIn this phase 3, double-blind, randomized, active-controlled trial, we randomly assigned participants a 2:1 ratio receive every 26 weeks or daily oral emtricitabine–tenofovir disoproxil fumarate (F/TDF). primary analysis compared the incidence...
Background: HIV incidence among US young, black men who have sex with (YBMSM) is high, and structural barriers (eg lack of health insurance) may limit access to Pre-exposure prophylaxis (PrEP). Research studies conducted YBMSM must ensure the best available prevention methods, including PrEP. Methods: We implemented an optional, nonincentivized PrEP program in addition standard services a prospective, observational cohort HIV-negative Atlanta, GA. Provider visits laboratory costs were...
Abstract Background Human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) has great potential to reduce HIV incidence among young black men who have sex with (YBMSM); however, initiation and persistence for this group remain low. We sought understand the patterns predictors of PrEP uptake discontinuation YBMSM in Atlanta, Georgia. Methods was offered all participants a prospective cohort aged 18–29 years not living HIV. Time uptake, first discontinuation, final were assessed...
Recruiting valid samples of men who have sex with (MSM) is a key component the US human immunodeficiency virus (HIV) surveillance and research studies seeking to improve HIV prevention for MSM. Social media, such as Facebook, may present an opportunity reach broad MSM, but extent which those are comparable recruited from venue-based, time-space sampling (VBTS) unknown.The objective this study was assess comparability MSM via VBTS Facebook.HIV-negative HIV-positive black white were June 2010...
The response in the United States to coronavirus disease (COVID-19) pandemic has been hampered by a lack of aggressive testing for infection. Testing severe acute respiratory syndrome 2 (SARS-CoV-2) is cornerstone an effective public health response. However, efforts test have limited reagents, limitations availability swabs used collection nasopharyngeal swab (NPS) specimens, personal protective equipment (PPE) care providers collecting NPS and viral transport media transporting specimens....
Data reporting sexually transmitted infection (STI) incidence rates among HIV-negative U.S. men who have sex with (MSM) are lacking. In addition, it is difficult to analyze the effect of STI on HIV acquisition given that sexual risk behaviors confound relationship between bacterial STIs and incident HIV. The InvolveMENt study was a longitudinal cohort black white HIV-negative, active MSM in Atlanta underwent routine screening for completed behavioral questionnaires. Age-adjusted were...
In Brief Background Studying the heterogeneity and correlates of HIV risk in sexual networks black white men who have sex with (MSM) may help explain racial disparities HIV-infection. Methods Black MSM were recruited as seeds using venue-based time sampling provided data regarding their recent partners. We used chain referral methods to enroll seeds' partners; newly enrolled partners turn on partners, some whom later enrolled. Data about unenrolled obtained from participants also analyzed....