Robert Grossberg
A5042001080- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- HIV-related health complications and treatments
- SARS-CoV-2 and COVID-19 Research
- Viral-associated cancers and disorders
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Head and Neck Cancer Studies
- HIV, Drug Use, Sexual Risk
- SARS-CoV-2 detection and testing
- Medication Adherence and Compliance
- Respiratory Support and Mechanisms
- Adolescent Sexual and Reproductive Health
- Bacillus and Francisella bacterial research
- Sexual function and dysfunction studies
- Respiratory viral infections research
- Risk Perception and Management
- Patient Dignity and Privacy
- Histiocytic Disorders and Treatments
- Multiple and Secondary Primary Cancers
Montefiore Medical Center
2012-2024
Albert Einstein College of Medicine
2010-2023
Icahn School of Medicine at Mount Sinai
2020
Office of Infectious Diseases
2015
Johns Hopkins University Center for AIDS Research
2008
University of Pennsylvania
2004-2007
Veterans Health Administration
2004
Background. The pilot phase IIb VIKING study suggested that dolutegravir (DTG), a human immunodeficiency virus (HIV) integrase inhibitor (INI), would be efficacious in INI-resistant patients at the 50 mg twice daily (BID) dose. Methods. VIKING-3 is single-arm, open-label III which therapy-experienced adults with received DTG BID while continuing their failing regimen (without raltegravir or elvitegravir) through day 7, after was optimized ≥1 fully active drug and continued. primary efficacy...
People living with human immunodeficiency virus (PLHIV) are at increased risk of atherosclerotic cardiovascular disease (ASCVD) and prone to statin-related adverse events from drug–drug interactions certain antiretroviral regimens. This study sought evaluate the efficacy safety evolocumab in dyslipidemic PLHIV. BEIJERINCK (EvolocumaB Effect on LDL-C Lowering SubJEcts Human Immunodeficiency VirRus INcreased Cardiovascular RisK) is a randomized, double-blind, multinational trial comparing...
Although antivirals remain important for the treatment COVID-19, methods to assess efficacy are lacking. Here, we investigated impact of remdesivir on viral dynamics and their contribution understanding antiviral in multicenter Adaptive COVID-19 Treatment Trial 1, which randomized patients or placebo.
In the phase 3 BRIGHTE study in heavily treatment-experienced adults with multidrug-resistant HIV-1, fostemsavir plus optimized background therapy (OBT) resulted sustained rates of virologic suppression through 96 weeks. HIV-1 RNA <40 copies/mL was achieved 163/272 (60%) Randomized Cohort (RC) participants (with 1 or 2 remaining approved fully active antiretrovirals) and 37/99 (37%) Non-randomized (NRC) 0 antiretrovirals). Here we report genotypic phenotypic analyses samples from 63/272...
Abstract The HIV-infected population in the USA is expanding as patients survive longer and new infections are identified. In many areas, particularly rural/medically underserved regions, there a growing shortage of providers with sufficient HIV expertise. services incorporated into community-based (CB), primary care settings may therefore improve distribution delivery treatment. Our objective was to describe/compare treatment outcomes two settings: community-located, care-based program,...
We evaluated the risk factors associated with oral human papillomavirus (HPV) infection and lesions in 161 immunodeficiency virus (HIV)-positive patients 128 HIV-negative presenting for examination at 2 urban healthcare centers. Patients were interviewed on provided oral-rinse samples HPV DNA typing by polymerase chain reaction. Statistical associations assessed logistic regression. Oral was prevalent 32% 16% of HIV-positive patients, respectively, including high-risk type 16 (8% 2%,...
The ACTT risk profile, which was developed from ACTT-1 (Adaptive COVID-19 Treatment Trial-1), demonstrated that hospitalized patients with in the high-risk quartile (characterized by low absolute lymphocyte count [ALC], high neutrophil [ANC], and platelet at baseline) benefited most treatment antiviral remdesivir. It is unknown patient characteristics are associated benefit immunomodulator baricitinib. To apply profile to ACTT-2 cohort investigate potential baricitinib-related effects...
Strict adherence to antiretroviral therapy is instrumental in viral suppression and treatment success. The relation between pharmacy-based factors has been under-explored. We aimed determine whether different medication refill mechanisms were associated with differences adherence.We conducted a retrospective cohort study of 110 HIV-infected subjects on standard regimens for >or=3 months cared at the Philadelphia Veterans' Affairs Medical Center HIV clinic. primary outcome was measure over 3...
Background VIKING‐3 aimed to examine efficacy and safety of dolutegravir (DTG) 50 mg twice daily in patients with resistance multiple ARV classes, including integrase inhibitors (INI). Methods RAL and/or EVG‐resistant (current or historical) adult subjects screening plasma HIV‐1 RNA ≥500 c/mL ≥2 other ART classes received open‐label DTG BID while continuing their failing regimen (without RAL/EVG). At Day 8 the background was optimised continued. Activity optimized (OBR) determined by...
Abstract This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create risk profile that better predicts than baseline oxygen requirement alone. The highest group derives greatest from RDV.
We performed anorectal testing in 18 cis-gender men who have sex with symptoms consistent mpox virus (MPXV) infection. found rectal MPXV DNA 9/9 and 7/9 without proctitis. Future study of is needed may inform the diagnosis pathogenesis disease.
There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women a high-prevalence community were screened AC with cytology and triage to high-resolution anoscopy after routine was implemented large urban hospital system. Of these, 75 (10.5%) had an abnormal 29 (38.7%) of those abnormality high-grade intraepithelial neoplasia (AIN). Women poorly controlled HIV significantly more likely have AIN (P = 0.03). Given the high rate...
Context: Current reports on human immunodeficiency virus (HIV) pain are limited to epidemiological data neuropathic in HIV and most studies were conducted before the availability of highly active antiretroviral therapy. Complex was reported be prevalent associated with advanced disease.Objectives: The authors a retrospective review medical records 81 patients from Center for Positive Living (CPL) at Montefiore Medical who newly referred management program 2006 identify potential benefits...
Follicular dendritic cell (FDC) sarcoma is an uncommon neoplasm occurring not only in lymph nodes but also extranodal sites. Because of increasing number case reports, awareness this tumor has grown. The nature the disease and its relation to other diseases, treatment, prognosis immunochemistry findings are being actively studied. So far, a limited cytology cases describing fine needle aspiration (FNA) biopsy FDC have been reported.A 47-year-old man had history hypertension human...
People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head neck cancer. We investigated effects of smoking on HPV risk. Consecutive PLWH (n = 169) at-risk HIV-negative individuals 126) were recruited from 2 US health centers. Smoking history was collected using questionnaires. Participants provided rinse samples genotyping. used multivariable logistic regression models interaction terms test effect HPV....
Disparities remain in HIV viral load (VL) suppression between people living with (PLWH) who use cocaine and those do not. It is not known how cannabis affects VL PLWH cocaine. We evaluated the relationship among conducted a secondary data analysis of 119 baseline interviews from randomized controlled trial Bronx, NY (6/2012 to 1/2017). Participants were adult prescribed antiretrovirals for ≥16 weeks, endorsed imperfect antiretroviral adherence used past 30-days. In bivariate multivariable...
There are few data on the rate of compliance with universal precautions among pediatricians. We hypothesized that in pediatrics would be poor because intrinsic difficulties performing invasive procedures small subjects.Prospective, observational study.Tertiary care children's hospital.A convenience sample pediatric house staff.Pediatric staff members were observed while procedures. Procedure type, number attempts required, and patient's age diagnosis recorded. Degree was judged by means...