A5104085413- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Primary Care and Health Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Sex work and related issues
- LGBTQ Health, Identity, and Policy
- Social and Intergroup Psychology
- Adolescent Sexual and Reproductive Health
- Mental Health and Patient Involvement
- Syphilis Diagnosis and Treatment
- Homelessness and Social Issues
- Adrenal Hormones and Disorders
- Smoking Behavior and Cessation
- Chronic Disease Management Strategies
- Organizational Strategy and Culture
- Viral Infectious Diseases and Gene Expression in Insects
- Plant Molecular Biology Research
- HIV/AIDS oral health manifestations
- Safe Handling of Antineoplastic Drugs
- Racial and Ethnic Identity Research
- Occupational exposure and asthma
- Neutropenia and Cancer Infections
University of California, San Francisco
2016-2024
Rutgers, The State University of New Jersey
2024
San Francisco General Hospital
2020-2021
University of California, Los Angeles
2019-2021
San Jose State University
2013
Parkland Health & Hospital System
2011
Montefiore Medical Center
2006-2011
Albert Einstein College of Medicine
2008-2011
Yeshiva University
2009-2011
Escuela Nacional de Antropología e Historia
2009
Since the beginning of AIDS epidemic, models HIV care have needed to be invented or modified as needs patients and communities evolved. Early in primary palliative predominated; subsequently, emergence effective therapy for infection led further specialization a focus on increasingly complex antiretroviral cornerstone care. Over past decade, factors including (1) an aging, long-surviving population; (2) multiple co-morbidities; (3) polypharmacy; (4) need chronic disease management evolution...
Background: Dolutegravir (DTG)-based antiretroviral therapy (ART) rarely leads to virological failure (VF) and drug resistance in integrase strand transfer inhibitor (INSTI)-naïve persons living with HIV (PLWH). As a result, limited data are available on INSTI-associated mutations (DRMs) selected by DTG-containing ART regimens. Methods: We reviewed studies published through July 2023 identify those reporting emergent major DRMs INSTI-naïve PLWH receiving DTG containing vitro susceptibility...
Background: Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk emergent integrase strand transfer inhibitor (INSTI) drug-resistance mutations (DRMs) in individuals receiving DTG-containing ART. Methods: We performed PubMed search using term “Dolutegravir”, last updated 18 December 2023, estimate prevalence VF with INSTI DRMs people living HIV (PLWH) without...
De novo DNA methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of mammalian de DNMT3. DRM2 targeted to small interfering RNAs (siRNAs) process known as RNA-directed Methylation (RdDM). While several components RdDM pathway are known, functional understanding underlying mechanism far from complete. We employed both forward and reverse genetic approaches identify factors involved methylation. utilized FWA transgene, which methylated silenced when...
Abstract Five long‐acting (LA) antiretrovirals (ARVs) are currently available in a limited number of countries worldwide for HIV‐1 prevention or treatment—cabotegravir, rilpivirine, lenacapavir, ibalizumab, and dapivirine. Implementing use LA ARVs into routine clinical practice requires significant changes to the current framework prevention, treatment, service provision. Given novelty, complexity, interdisciplinary requirements needed safely optimally utilize ARVs, consensus recommendations...
ABSTRACT Background Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk virological failure (VF) with emergent integrase strand transfer inhibitor (INSTI) drug-resistance mutations (DRMs) in individuals receiving DTG-containing ART. Methods We performed PubMed search using term “Dolutegravir” last updated December 18, 2023, estimate prevalence VF INSTI DRMs...
Exposure to hepatitis viruses is a recognized occupational risk for health care personnel (HCP). This report establishes new CDC guidance that includes recommendations testing algorithm and clinical management HCP with potential exposure C virus (HCV). Baseline of the source patient should be performed as soon possible (preferably within 48 hours) after exposure. A refers any person receiving services whose blood or other potentially infectious material HCP's Two options are recommended...
Five long-acting (LA) antiretrovirals (ARVs) are currently available in a limited number of countries worldwide for HIV-1 prevention or treatment - cabotegravir, rilpivirine, lenacapavir, ibalizumab, and dapivirine. Implementing use LA ARVs routine clinical practice requires significant changes to the current framework prevention, treatment, service provision. Given novelty, complexity, interdisciplinary requirements safe optimal ARVs, consensus recommendations on will assist clinicians...
Tobacco companies use price discounts, including coupons and rebates, to market their products. Lesbian, gay, bisexual, transgender, queer (LGBTQ+) communities are targeted by these marketing strategies, contributing inequitably high tobacco use. Some localities have adopted policies restricting discounts; for successful implementation, community buy-in is crucial. From July-October 2018, Equality California staff conducted semi-structured interviews with seven participants in Los Angeles,...
BackgroundThe National Clinician Consultation Center (NCCC) operates the PEPline, a federally-funded educational resource providing bloodborne pathogen exposure management tele-consultation to U.S. clinicians.Methods67,109 occupational post-exposure prophylaxis (PEP) consultations (January 2014 December 2022) were retrospectively analyzed describe PEPline utilization and common inquiries addressed by NCCC consultants.ResultsMost calls involved percutaneous incidents (70%); blood was most...
Abstract There is a decreasing HIV care workforce in the United States, whereas need for and prevention continues to increase. To better understand this issue, quantitative, anonymous, one-time, self-administered survey was conducted. The completed by 1,004 prescribing clinicians currently providing HIV-related health care. Clinicians of younger age Black race, advanced practice registered nurses, family medicine physicians were more likely report continuing with same number patients or...
The swimming behavior of Escherichia coli at any moment is dictated by the intracellular concentration phosphorylated form chemotaxis response regulator CheY, which binds to base flagellar motor. CheY on Asp57 sensor kinase CheA and dephosphorylated CheZ. Previous work (Silversmith et al., J. Biol. Chem. 276:18478, 2001) demonstrated that replacement Asn59 with arginine resulted in extreme resistance dephosphorylation CheZ despite proficient binding Here we present X-ray crystal structure...
Abstract A variety of genetic techniques have been devised to determine cell lineage relationships during tissue development. Some these systems monitor lineages spatially and/or temporally without regard gene expression by the cells, whereas others correlate with under study. The GAL4 Technique for Real-time and Clonal Expression (G-TRACE) system allows rapid, fluorescent protein-based visualization both current past patterns is therefore amenable genome-wide expression-based screens. Here...
Abstract Introduction Relatively little has been published on human immunodeficiency virus (HIV) pre‐exposure prophylaxis (PrEP) training efforts and outcomes among clinicians working at community health centers safety net clinical settings. Objectives This study describes the National Clinician Consultation Center's (NCCC's) PrEP content development learning outcomes. Methods The consisted of a multidisciplinary capacity‐building program designed to increase PrEP‐related knowledge skills...
Abstract Background Long-acting cabotegravir (CAB-LA) is highly effective for HIV prevention, but delayed diagnoses and integrase strand transfer inhibitor (INSTI) resistance were observed in trials. We report the first case routine clinical care of infection on CAB-LA with INSTI resistance. Methods The SeroPrEP study enrolls individuals United States who acquire pre-exposure prophylaxis modalities to assess diagnostics, antiretroviral (ARV) drug levels, resistance, treatment outcomes....
We examined the impact of arrest and incarceration on primary care patients in Bronx, New York.Patients at three clinics were asked eight questions concerning current past involvement criminal proceedings, arrest, incarceration.One hundred eighteen surveyed. Eleven (9%) currently involved proceedings. Twenty-one (18%) had a family member jail or prison. Twenty-nine (25%) reported ever being arrested; 65 (55%) that they been arrested. incarcerated; 60 (51%) spent time For most variables,...