A5019376012- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Neonatal and fetal brain pathology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Advanced Causal Inference Techniques
- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- LGBTQ Health, Identity, and Policy
- Statistical Methods and Inference
- Prion Diseases and Protein Misfolding
- COVID-19 and Mental Health
- Dialysis and Renal Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 epidemiological studies
- Adolescent Sexual and Reproductive Health
- Ocular Infections and Treatments
- Sex work and related issues
- Intraocular Surgery and Lenses
- Transplantation: Methods and Outcomes
University of California, San Francisco
2016-2025
University of the Witwatersrand
2024
Universidad Católica de Santa Fe
2024
University of North Carolina at Chapel Hill
2023
Icahn School of Medicine at Mount Sinai
2022
Center for Neurosciences
2022
Cancer Research And Biostatistics
2005-2021
San Francisco General Hospital
2004-2020
Washington University in St. Louis
2020
Legacy Health
2020
Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus (HIV) acquisition.
PrEP drug concentrations associated with ≥90% reduction in HIV acquisition men who have sex are achieved daily dosing.
Congenital heart disease in newborns is associated with global impairment development. We characterized brain metabolism and microstructure, as measures of maturation, congenital before they underwent surgery.We studied 41 term disease--29 who had transposition the great arteries 12 single-ventricle physiology--with use magnetic resonance imaging (MRI), spectroscopy (MRS), diffusion tensor (DTI) cardiac surgery. calculated ratio N-acetylaspartate to choline (which increases maturation),...
Prions are proteins that adopt alternative conformations become self-propagating; the PrP Sc prion causes rare human disorder Creutzfeldt–Jakob disease (CJD). We report here multiple system atrophy (MSA) is caused by a different composed of α-synuclein protein. MSA slowly evolving characterized progressive loss autonomic nervous function and often signs parkinsonism; neuropathological hallmark glial cytoplasmic inclusions consisting filaments α-synuclein. To determine whether forms prions,...
Although renal insufficiency is a recognized risk factor for coronary artery disease, little known about the epidemiology of lower-extremity peripheral arterial disease (PAD) in persons with insufficiency.We examined cross-sectional association PAD, defined as an ankle-brachial index (ABI) <0.9, and insufficiency, estimated creatinine clearance (CRCL) <60 mL. min(-1). 1.73 m(-2), among 2229 eligible participants National Health Nutrition Examination Survey (NHANES) 1999 to 2000. An 1.2+/-0.3...
Background and Purpose— Brain injury is common in newborns with congenital heart disease (CHD) requiring neonatal surgery. The purpose of this study to define the risk factors for preoperative postoperative brain injuries their association functional cardiac anatomic groups. Methods— Sixty-two neonates CHD were studied MRI, 53 received scans. Clinical therapeutic characteristics compared without newly acquired injuries. A subset 16 consecutive patients was monitored intraoperative cerebral...
<b>BACKGROUND AND PURPOSE:</b> Plaque morphologic features have been suggested as a complement to luminal narrowing measurements for assessing the risk of stroke associated with carotid atherosclerotic disease, giving rise concept “vulnerable plaque.” The purpose this study was evaluate ability multidetector-row CT angiography (CTA) assess composition and characteristics artery plaques use histologic examination gold standard. <b>MATERIALS METHODS:</b> Eight patients transient ischemic...
Losses to follow-up after initiation of antiretroviral therapy (ART) are common in Africa and a considerable obstacle understanding the effectiveness nascent treatment programs. We sought characterize, through sampling-based approach, reasons for outcomes patients who become lost follow-up.Cohort study.We searched interviewed representative sample or close informants community determine among patients.Three thousand six hundred twenty-eight HIV-infected adults initiated ART between January...
The biological processes associated with postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) are unknown.
Objective Preexposure prophylaxis (PrEP) with emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) reduced HIV acquisition in the iPrEx trial among men who have sex and transgender women. Self-reported sexual risk behavior decreased overall, but may be affected by reporting bias. We evaluated potential compensation using biomarkers of behavior. Design methods Sexual practices were assessed at baseline quarterly thereafter; perceived treatment assignment PrEP efficacy beliefs 12 weeks. Among...
BackgroundMost cohorts show similar or lower COVID-19 incidence among people living with HIV compared the general population. However, might be affected by testing rates vulnerable populations. We aimed to compare SARS-CoV-2 IgG seroprevalence, disease severity, and neutralising antibody activity after infection without receiving care in a county hospital system over 3-month period.MethodsIn this matched case-control observational study, remnant serum samples were collected between Aug 1 Oct...
Intramuscular cabotegravir (CAB) and rilpivirine (RPV) is the only long-acting antiretroviral therapy (LA-ART) regimen approved for people with HIV (PWH). Long-acting ART holds promise improving outcomes among populations barriers to adherence but PWH who have virologic suppression use of oral before initiating injectables.
<b><i>Background:</i></b> There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage developing brain. <b><i>Objective:</i></b> To determine if seizures are independently associated with injury in newborns perinatal asphyxia. <b><i>Methods:</i></b> Ninety term neonates were studied MRI and single-voxel <sup>1</sup>H-MRS on median day life 6 (range 1 to 13 days). The severity MR abnormality regions interest was scored using a...