A5087601006- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- Pneumocystis jirovecii pneumonia detection and treatment
- LGBTQ Health, Identity, and Policy
- Liver Disease Diagnosis and Treatment
- Syphilis Diagnosis and Treatment
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Reproductive tract infections research
- Viral-associated cancers and disorders
- Long-Term Effects of COVID-19
- Genital Health and Disease
- Antifungal resistance and susceptibility
- Science and Education Research
Fundação Oswaldo Cruz
2016-2025
Instituto Evandro Chagas
2016-2025
Instituto Nacional de Saúde
2022-2024
National Institute of Infectious Diseases
2021-2023
Faculdades Oswaldo Cruz
2022-2023
Creative Commons
2023
Academia Nacional de Medicina
2023
Secretaria de Ciência, Tecnologia e Inovação
2023
Ministério da Saúde
2022
Sexual Health Clinic
2022
Antiretroviral chemoprophylaxis before exposure is a promising approach for the prevention of human immunodeficiency virus (HIV) acquisition.
PrEP drug concentrations associated with ≥90% reduction in HIV acquisition men who have sex are achieved daily dosing.
Antiretroviral therapy (ART) is indicated during tuberculosis treatment in patients infected with human immunodeficiency virus type 1 (HIV-1), but the timing for initiation of ART when diagnosed various levels immune compromise not known.We conducted an open-label, randomized study comparing earlier (within 2 weeks after tuberculosis) later (between 8 and 12 HIV-1 CD4+ T-cell counts less than 250 per cubic millimeter suspected tuberculosis. The primary end point was proportion who survived...
The safety and efficacy of adding antiretroviral drugs to standard zidovudine prophylaxis in infants mothers with human immunodeficiency virus (HIV) infection who did not receive antenatal therapy (ART) because late identification are unclear. We evaluated three ART regimens such infants.
BACKGROUNDAlthough convalescent plasma has been widely used to treat severe coronavirus disease 2019 (COVID-19), data from randomized controlled trials that support its efficacy are limited.METHODSWe conducted a randomized, double-blind, trial among adults hospitalized with and critical COVID-19 at 5 sites in New York City (USA) Rio de Janeiro (Brazil). Patients were 2:1 receive single transfusion of either or normal control plasma. The primary outcome was clinical status 28 days following...
Obesity rates are increasing among HIV-infected individuals, but risk factors for obesity development on ART remain unclear.In a cohort of adults in Rio de Janeiro, Brazil, we aimed to determine before and after initiation analyse ART.We retrospectively analysed data from individuals initiating between 2000 2015. BMI was calculated at baseline (time initiation). Participants who were non-obese had ≥90 days exposure followed until the or end follow-up. incidence estimated using Poisson...
Syphilis infection may potentiate transmission of human immunodeficiency virus (HIV). We sought to determine the extent which HIV acquisition was associated with syphilis within an preexposure prophylaxis (PrEP) trial and whether emtricitabine/tenofovir (FTC/TDF) modified that association.The Preexposure Prophylaxis Initiative (iPrEx) study randomly assigned 2499 HIV-seronegative men transgender women who have sex (MSM) receive oral daily FTC/TDF or placebo. prevalence at screening incidence...
Daily preexposure prophylaxis (PrEP) with oral emtricitabine and tenofovir disoproxil fumarate (FTC/TDF) decreases the risk of human immunodeficiency virus (HIV) acquisition. Initiation TDF bone mineral density (BMD) in HIV-infected people. We report effect FTC/TDF on BMD HIV-seronegative men who have sex transgender women.Dual-energy X-ray absorptiometry was performed at baseline 24-week intervals a substudy iPrEx, randomized, double-blind, placebo-controlled trial PrEP. Plasma...
Tenofovir disoproxil fumarate (TDF) pre-exposure prophylaxis decreases sexual acquisition of HIV infection. We sought to evaluate the renal safety TDF in HIV-uninfected persons.The Iniciativa Profilaxis Pre-Exposición (iPrEx) study randomly assigned 2499 HIV-seronegative men and transgender women who have sex with (MSM) receive oral daily coformulated emtricitabine (FTC/TDF) or placebo. Serum creatinine phosphorus during randomized treatment after discontinuation were measured, clearance...
We describe temporal trends in the mortality rates and factors associated with AIDS non-AIDS related at Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ).Adult patients enrolling from 1986 through 2009 a minimum follow up of 60 days were included. Vital status was exhaustively checked using patients' medical charts, active contact individuals family members by linkage Rio de Janeiro Mortality database previously validated algorithm. The CoDe protocol used...
We conducted a web-based survey to understand the impact of social distancing measures on Brazilian MSM and transgender/non-binary lives. A total 3486 respondents were included in this analysis great majority cismen (98%). The median age was 32 years (IQR: 27-40), 44% non-white, 36% low schooling 38% income. Most participants reported HIV negative/unknown status (77%). Participants on-PrEP more condomless anal sex than those off-PrEP. Conversely, 24% off-PrEP at substantial HIV-risk....
Abstract Introduction : The efficacy of pre‐exposure prophylaxis (PrEP) in preventing sexual acquisition human immunodeficiency virus (HIV) is well established. Little known about the feasibility PrEP implementation middle‐income settings with concentrated epidemics among men who have sex (MSM) and transgender women (TGW). Methods Brasil a prospective, multicentre, open‐label demonstration project assessing delivery context Brazilian Public Health System. HIV‐uninfected MSM TGW 3 referral...
OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in state Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 from April 14 27, 2020. This study reports crude prevalence SARS-CoV-2, population weighted for state, and adjusted test sensitivity specificity. Logistic regression models used establish correlates prevalence. For analysis, we considered collection period site, sociodemographic characteristics, place residence. RESULTS The proportion...
HIV disproportionally affects key populations including men who have sex with (MSM). prevalence among MSM varies from 17% in Brazil and Mexico to 13% Peru, whereas it is below 0.5% for the general population each country. Pre-exposure prophylaxis (PrEP) emtricitabine/tenofovir being implemented context of combination prevention. Reports on willingness use PrEP started emerge over last few years. Previously reported factors associated include awareness, higher sexual risk behavior, previous...
COVID-19 public health responses such as social distancing and community containment measures protocols are critical to preventing containing the spread of coronavirus. Brazil accounts for almost half Latin American HIV cases Rio de Janeiro is city with second largest number AIDS. Clinical appointments pharmacy antiretroviral refills may be impaired due restricted traffic possible lockdowns, people living those using PrEP from accessing needed antiretrovirals. We hereby describe telemedicine...