A5078993254- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- LGBTQ Health, Identity, and Policy
- Adolescent Sexual and Reproductive Health
- HIV-related health complications and treatments
- Science and Education Research
- HIV/AIDS drug development and treatment
- Sex work and related issues
- Health Systems, Economic Evaluations, Quality of Life
- Public Health in Brazil
- Sexuality, Behavior, and Technology
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmaceutical Economics and Policy
- Neuroscience and Neuropharmacology Research
- HIV/AIDS Impact and Responses
- Tuberculosis Research and Epidemiology
- Chemical Synthesis and Analysis
- Pregnancy and Medication Impact
- African Sexualities and LGBTQ+ Issues
- Computational Drug Discovery Methods
- Patient Safety and Medication Errors
Fundação Oswaldo Cruz
2013-2023
Instituto Evandro Chagas
2017-2021
Abstract Introduction : The efficacy of pre‐exposure prophylaxis (PrEP) in preventing sexual acquisition human immunodeficiency virus (HIV) is well established. Little known about the feasibility PrEP implementation middle‐income settings with concentrated epidemics among men who have sex (MSM) and transgender women (TGW). Methods Brasil a prospective, multicentre, open‐label demonstration project assessing delivery context Brazilian Public Health System. HIV‐uninfected MSM TGW 3 referral...
Tuberculosis is the most frequent opportunistic infection and leading cause of death among persons living with HIV in several low middle-income countries. Mortality rates during tuberculosis treatment causes HIV-1/TB co-infected patients may differ based on immunosuppression severity, timing diagnosis prompt initiation antiretroviral therapy. This was a retrospective observational study conducted clinical cohort HIV-1/Aids National Institute Infectious Diseases Evandro Chagas, Rio de...
Brazil has the largest population of individuals living with HIV/AIDS in Latin America, a disproportional prevalence infection among gays, bisexuals and other men who have sex (MSM). Of relevance to prevention treatment efforts, Brazilian MSM from different regions may differ behaviors risk perception related HIV.We report on 29 cities: 26 state capitals, Federal District two large cities São Paulo assessed three web-based surveys (2016-2018) advertised Grindr, Hornet Facebook. Using...
The introduction of highly active antiretroviral therapy during the 1990s was crucial to decline in rates morbidity and death related acquired immunodeficiency syndrome (AIDS) turned human virus (HIV) infection into a chronic condition. Consequently, HIV/AIDS population is becoming older. aim this study describe immunological, clinical comorbidity profile an urban cohort patients with followed up at Instituto de Pesquisa Clinica Evandro Chagas, Oswaldo Cruz Foundation Rio Janeiro, Brazil....
Introduction Efficacy of daily emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) for PrEP is strongly dependent on the adherence. We examined concordance between indirect adherence measures and protective drug levels among participants retained through 48 weeks in Brasil Study. Methods was a prospective, multicenter, open-label demonstration project evaluating provision men who have sex with (MSM) transgender women (TGW) at higher risk HIV infection within setting Brazilian Public Health...
Abstract Background HIV-related stigma, or the degree to which people living with HIV endorse negative stereotypes associated HIV, is poor continuum of care outcomes. We translated 12-item Short Stigma scale and evaluated its psychometric properties in a Brazilian context regard construct validity reliability. Methods The first step included translation, back-translation, evaluation, peer review, pre-testing Sigma developed by Reinius et al. (Health Qual Life Outcomes 15(1):115, 2017)....
ABSTRACT A lopinavir-ritonavir (LPV/r)-based regimen is recommended during pregnancy to reduce the risk of HIV mother-to-child transmission, but appropriate dose controversial. We compared pharmacokinetics standard and increased LPV/r doses pregnancy. This randomized, open-label prospective study enrolled 60 pregnant women between gestational weeks 14 30. The participants received either (400/100 mg twice a day [BID]) or (600/150 BID) tablets for 6 after childbirth. Pharmacokinetics analysis...
Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection remains an important cause new HIV infections worldwide, especially in low and middle-resource limited countries. Safety data from studies involving pregnant women prenatal antiretroviral (ARV) exposure are still needed once these often small with a duration to assess adverse drug reactions (ADR). The aim this study was estimate the incidence ADR related use therapy (ART) two referral centers Rio de Janeiro...
Abstract Background Valid and reliable instruments are needed to measure the multiple dimensions of perceived risk. The Perceived Risk HIV Scale is an 8-item that assesses how people think feel about their risk infection. We set out perform a cross-cultural adaptation scale Brazilian Portuguese among key populations (gay, bisexual other men who have sex with transgender/non-binary) (cisgender heterosexual cisgender women). Methods Methodological study cross-sectional design conducted online...
Understanding the factors associated with pre-exposure prophylaxis (PrEP) adherence may help in development of strategies to support, motivate and sustain PrEP use. This study estimated self-reported adherence, described perceived barriers facilitators investigated daily oral among men who have sex man (MSM) transgender women after 1 year use Brazil. Brasil was a prospective, multicentre, open-label demonstration MSM at high risk for HIV infection. We used logistic regression evaluate...
Abstract Objectives Potential interactions between feminizing hormone therapy (FHT) and pre-exposure prophylaxis (PrEP) may be a barrier to PrEP use among transgender women (TGW). We aimed assess the impact of FHT on plasma pharmacokinetics (PK) TGW. Methods This was PK substudy effects tenofovir disoproxil fumarate/emtricitabine nested trans-specific demonstration study (NCT03220152). Participants were assigned receive only (noFHT) or standardized (sFHT; oestradiol valerate 2–6 mg plus...
An important barrier to HIV prevention among transgender women (TGW) is the concern that oral pre-exposure prophylaxis (PrEP) negatively affects efficacy of feminizing hormone therapy (FHT). We aimed assess impact PrEP on FHT pharmacokinetics (PK) TGW from Brazil. performed a drug-drug interaction sub-study enrolled in daily demonstration study (PrEParadas, NCT03220152). Participants had first PK assessment (PK1) 15 days after (estradiol valerate 2–6 mg plus spironolactone 100–200 mg)...
Knowledge about HIV transmission and prevention is a necessary step for adopting preventive behaviors. We assessed knowledge its correlation with the perceived accuracy of "Undetectable = Untransmittable" (U=U) slogan in an online sample 401 adult Brazilians. Overall, 28% participants showed high level. The U=U significantly correlated knowledge. Younger participants, those reporting lower income or education, who had never tested poorer Filling gaps among specific populations urgent order...
Internalized homonegativity results from the acceptance of negative attitudes about one's same-sex orientation, which has consequences for health gay, bisexual and other men who have sex with (GBM). We translated 7-item Reactions to Homosexuality Scale (RHS) Brazilian Portuguese assessed its factor structure, validity reliability. The first step included translation, back-translation, evaluation, peer review, pre-testing scale. Then, we piloted scale in two convenience samples adult...
Recently, many efforts have been made to develop N-methyl-D-aspartic acid receptor antagonists for treating different pathological conditions such as thrombo-embolic stroke, traumatic head injury, Huntington's, Parkinson's, and Alzheimer's diseases). However, side-effects limit the use of most antagonists, new drugs are still required. In this work, we performed a (quantitative) structure-activity relationship analysis 17 phenyl-amidine derivatives (1a-1q), reported used data rationally...
The increased survival provided by the access, development, and evolution of antiretroviral drugs (ARV) greatly life expectancy people living with HIV (PWH). This has also led to an occurrence diseases or morbidities related aging. In individuals multiple comorbidities, simultaneous use medications, known as polypharmacy, is common, rational medications essential. study aims describe pharmacotherapeutic profile, estimate prevalence polypharmacy identify factors associated in a cohort adult...
Abstract Background Brazil has the largest population of individuals living with HIV /AIDS in Latin America, a disproportional prevalence infection among gays, bisexuals and other men who have sex (MSM). Of relevance to prevention treatment efforts, Brazilian MSM from different regions may differ behaviors risk perception related .Methods We report on 29 cities: 26 state capitals, Federal District two large cities São Paulo assessed three web-based surveys (2016-2018) advertised Grindr,...
Abstract Background: Brazil has the largest population of individuals living with HIV/AIDS in Latin America, a disproportional prevalence infection among gays, bisexuals and other men who have sex (MSM). Of relevance to prevention treatment efforts, Brazilian MSM from different regions may differ behaviors risk perception related HIV. Methods: We report on 29 cities: 26 state capitals, Federal District two large cities São Paulo assessed three web-based surveys (2016-2018) advertised Grindr,...