A5035409979- Reproductive tract infections research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Hepatitis C virus research
- Syphilis Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Poxvirus research and outbreaks
- Zoonotic diseases and public health
- Bacillus and Francisella bacterial research
- Sexual function and dysfunction studies
- Sex work and related issues
- Pancreatitis Pathology and Treatment
- Pregnancy and Medication Impact
- Female Genital Mutilation/Cutting Issues
- Gut microbiota and health
- HIV, Drug Use, Sexual Risk
- Genital Health and Disease
- Liver Disease and Transplantation
Instituto Evandro Chagas
2024
University of California, Los Angeles
2020-2021
Fundação Oswaldo Cruz
2014-2021
Children's Hospital of Los Angeles
2014
Non-alcoholic fatty liver disease is characterized by the presence of hepatic steatosis and can be associated with fibrosis progression, development cirrhosis liver-related complications. Data on prevalence in HIV patients remain contradictory resource-limited settings. We aimed to describe factors mono-infection under long-term antiretroviral therapy (ART) Rio de Janeiro, Brazil.Clinical assessment, fasting blood collection stiffness measurement (LSM)/controlled attenuation parameter (CAP)...
Abstract Background Gender reassignment surgery is a procedure some transgender women (TW) undergo for gender-affirming purposes. This often includes the construction of neovagina using existing penile and scrotal tissue and/or sigmoid colon graft. There are limited data regarding composition function neovaginal microbiome representing major gap in knowledge health. Results Metaproteomics was performed on secretions collected from neovaginas ( n = 5) rectums 7) TW surgically reassigned via...
Sexually transmitted diseases (STD) are frequently asymptomatic and increase the likelihood of transmitting acquiring HIV. In Brazil, guidelines for STDs diagnosis treatment based on syndromic approach. Nucleic acid amplification tests (NAAT) has been recommended as routine screening in some countries, especially men who have sex with (MSM). Limited data available about how to best define target groups by NAATs within this population. We aimed assess prevalence rectal urethral Chlamydia...
Following the 2022 global mpox outbreak, diagnoses decreased worldwide, even in settings with limited vaccine access. In 2023-2024, a new outbreak emerged Rio de Janeiro, Brazil, highlighting importance of continuous surveillance, preventive measures such as vaccination vulnerable populations, and treatment options, emphasizing equitable health technology distribution.
Objectives We aimed to evaluate the accuracy of serological biomarkers for non‐alcoholic fatty liver disease (NAFLD) and advanced fibrosis (METAVIR‐F3F4) in HIV mono‐infected individuals. Methods In all, 674 participants from PROSPEC‐HIV study (NCT02542020), who had blood sample tests transient elastography (TE) performed on same day, were eligible. Exclusion criteria viral hepatitis co‐infection ( n = 90), abusive alcohol intake 61), missing data 47) or unreliable TE 39). NAFLD was defined...
ABSTRACT A lopinavir-ritonavir (LPV/r)-based regimen is recommended during pregnancy to reduce the risk of HIV mother-to-child transmission, but appropriate dose controversial. We compared pharmacokinetics standard and increased LPV/r doses pregnancy. This randomized, open-label prospective study enrolled 60 pregnant women between gestational weeks 14 30. The participants received either (400/100 mg twice a day [BID]) or (600/150 BID) tablets for 6 after childbirth. Pharmacokinetics analysis...
Many countries are facing concentrated HIV epidemics among vulnerable populations, including men who have sex with (MSM). Unprotected anal intercourse (UAI) is the main transmission route them and its understanding in different cultures how it relates to transmission, re-infection development of antiretroviral resistance has important public health implications. Data on UAI Brazilian MSM scarce. This study aims evaluate prevalence associated factors HIV-infected had seronegative or male...
Objective: The rectal microbiome was examined to assess the relationship between and liver disease in HIV-infection. Design: Eighty-two HIV-1 mono-infected individuals from PROSPEC-HIV-study (NCT02542020) were grouped into three health categories based on results of controlled attenuation parameter (CAP) stiffness measurement (LSM) transient elastography: normal ( n = 30), steatosis or fibrosis 22). Methods: Liver defined by CAP at least 248 dB/m LSM 8.0 kPa, respectively. 16S rRNA gene...
To evaluate the prevalence and characteristics of concurrent bacterial sexually transmitted infections (bSTIs) among individuals with mpox.