A5028031403- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Systemic Lupus Erythematosus Research
- Reproductive System and Pregnancy
- T-cell and Retrovirus Studies
- Air Quality and Health Impacts
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Vitamin C and Antioxidants Research
- Asthma and respiratory diseases
- Hepatitis B Virus Studies
- Genomics, phytochemicals, and oxidative stress
- Dermatologic Treatments and Research
- Liver Disease Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Pancreatic function and diabetes
Universidade do Estado do Rio de Janeiro
2016-2025
Hospital Central da Polícia Militar
2024
Universidade do Vale do Rio dos Sinos
2022
Universidade Federal do Rio Grande do Sul
2022
Weatherford College
2022
Hospital de Clínicas de Porto Alegre
2022
Universidade Federal do Rio de Janeiro
1998-2021
University Hospital Frankfurt
2016-2021
Goethe University Frankfurt
2004-2021
Institute of Dermatology
2020
OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in state Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 from April 14 27, 2020. This study reports crude prevalence SARS-CoV-2, population weighted for state, and adjusted test sensitivity specificity. Logistic regression models used establish correlates prevalence. For analysis, we considered collection period site, sociodemographic characteristics, place residence. RESULTS The proportion...
Long-term infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a challenge to virus dispersion and the control disease 2019 (COVID-19) pandemic. The reason why some people have prolonged how persists for so long are still not fully understood. Recent studies suggested that accumulation intra-host single nucleotide variants (iSNVs) over course might play an important role in persistence as well emergence mutations concern. For this reason, we aimed investigate...
Short term inhalation of cigarette smoke (CS) induces significant lung inflammation due to an imbalance oxidant/antioxidant mechanisms. Açai fruit (Euterpe oleracea) has antioxidant and anti-inflammatory actions. The present study aimed determine whether oral administration açai stone extract (ASE) could reduce induced by CS. Thirty C57BL/6 mice were assigned three groups (n=10 each): the Control+A group was exposed ambient air treated orally with ASE 300 mg/kg/day; CS from 6 cigarettes per...
Summary In this study our aim was to investigate the time courses of inflammation, oxidative stress and tissue damage after hyperoxia in mouse lung. Groups BALB/c mice were exposed 100% oxygen a chamber for 12, 24 or 48 h. The controls subjected normoxia. results showed that IL‐6 increased progressively 12 ( P < 0.001) h with reduction at 0.01), whereas TNF‐α 0.001). number macrophages 0.001), neutrophils 0.01) Superoxide dismutase activity decreased all groups 0.01). Catalase only...
Evatuate if Bacillus Calmette-Guérin (BCG) vaccine could be used as a tool against SARS-CoV-2 based on the concept of trained immunity.A multicenter, double-blinded, randomized clinical trial recruited health care workers (HCWs) in Brazil. The incidence rates COVID-19, manifestations, absenteeism, and adverse events among HCWs receiving BCG (Moreau or Moscow strains) placebo were compared. vaccine-mediated immune response before after implementing specific vaccines for COVID-19 (CoronaVac...
Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance extracellular matrix elements in tissue repair, a morphological quantitative analysis elastic system components (fibrillin‐1 elastin) was performed normal skin, scars, hypertrophic keloids. In superficial deep dermis, fibrillin‐1 volume density significantly higher skin compared with The did not show differences between or dermis. elastin skins, scars. We showed that distribution is...
Cigarette smoke (CS) causes pulmonary emphysema in humans and elastin degradation plays a key role its pathogenesis. Previous studies on CS-exposed animals have been equivocal not clearly demonstrated the progression of disease. In this study, morphometry was used to assess lung modifications alveolar septa, airspaces, elastic collagen fibers, macrophages. Male (n = 40) C57/BL6 mice were exposed 3 times/day, whole body, CS from three cigarettes for 10, 20, 30, or 60 days. Control groups 10)...
Our aim was to investigate the role of oxidative stress in elastase-induced pulmonary emphysema. C57BL/6 mice were subjected pancreatic porcine elastase (PPE) instillation (0.05 or 0.5 U per mouse, i.t.) induce Lungs collected on days 7, 14, and 21 after PPE instillation. The control group sham injected. Also, treated with 1% aminoguanidine (AMG) inducible NO synthase (iNOS) knockout received (i.t.), lungs analyzed after. We performed bronchoalveolar lavage, biochemical analyses stress, lung...
Stress impairs cutaneous wound healing; however, it is unclear how beta-adrenoceptors participates in alterations induced by stress on skin repair. Therefore, the aim of this study was to investigate effects propranolol, a non-selective beta-blocker, administration healing chronically stressed mice. Male mice were spun at 115 rpm for 15 min every hour from three days before wounding until euthanasia. Control animals not submitted stress. Stressed and control treated with propranolol...
The killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop (IHIWS) sought to explore worldwide population variation in KIR loci, and examine relationship between genes their human leukocyte antigen (HLA) ligands. Fifteen laboratories submitted genotype HLA ligand data 27 populations from six broad ethnic groups. Data were analyzed for correlations frequencies known In addition, allelic typing was performed KIR2DL2 3DL1 a subset...
Cigarette smoke (CS)-induced emphysema is caused by a continuous inflammatory response in the lower respiratory tract. The development of condition believed to be mediated oxidant-antioxidant imbalance. This paper describes effects long-term CS exposure on alveolar cell recruitment, antioxidant defense systems, activity extracellular matrix metalloelastases, expression metalloelastase MMP-12, and high mobility group box-1 protein (HMGB-1). Ten C57Bl/6 mice were exposed 12 cigarettes-a-day...