A5004301649- Toxoplasma gondii Research Studies
- Mesenchymal stem cell research
- Liver physiology and pathology
- Parasitic Infections and Diagnostics
- Cytomegalovirus and herpesvirus research
- Organ Transplantation Techniques and Outcomes
- Adipose Tissue and Metabolism
- Rabies epidemiology and control
- Pancreatic function and diabetes
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Hematopoietic Stem Cell Transplantation
- Eicosanoids and Hypertension Pharmacology
- Bone and Dental Protein Studies
- Tissue Engineering and Regenerative Medicine
- Diet and metabolism studies
- dental development and anomalies
- Metabolism, Diabetes, and Cancer
- Connective tissue disorders research
- Sodium Intake and Health
- Congenital heart defects research
- Nuclear Structure and Function
- Inflammatory Bowel Disease
- Heme Oxygenase-1 and Carbon Monoxide
Universidade do Estado do Rio de Janeiro
2011-2023
Chelsea and Westminster Hospital NHS Foundation Trust
2019
Fundação Oswaldo Cruz
2008-2014
Cultura
2006-2013
Instituto Piaget
2013
IdMind (Portugal)
2010
Instituto de Gastroenterología
2010
Universidade de São Paulo
2008
Universidade Estadual Paulista (Unesp)
2005
Instituto Nacional de Traumatologia e Ortopedia
2005
The aim of the present study was to evaluate effects monotherapies and combinations drugs on insulin sensitivity, adipose tissue morphology, pancreatic hepatic remodelling in C57BL/6 mice fed a very HF (high-fat) diet. Male were an (60% lipids) diet or SC (standard chow; 10% for 10 weeks, after which time following drug treatments began: HF-T (HF treated with telmisartan; 5.2 mg x kg-1 body weight day-1), HF-S sitagliptin; 1.08 g weight.day-1), HF-M metformin; 310.0 HF-TM...
The aim of this study was to investigate the effect a polyphenol-rich Açaí seed extract (ASE, 300 mg/kg-1d-1) on adiposity and hepatic steatosis in mice that were fed high-fat (HF) diet its underlying mechanisms based lipid metabolism oxidative stress. Four groups studied: C57BL/6 with standard (10% fat, Control), 10% fat + ASE (ASE), 60% (HF), (HF ASE) for 12 weeks. We evaluated food intake, body weight gain, serum glucose profile, cholesterol triacyglycerol (TG), expression pAMPK,...
O trauma é uma das principais causas de mortalidade em jovens, demandando manejo rápido e multidisciplinar para estabilização recuperação. Protocolos baseados evidências tecnologias imagem são fundamentais na avaliação intervenção. A colaboração entre especialidades médicas a personalização do tratamento contribuem melhores desfechos clínicos. reabilitação física o suporte psicológico essenciais reintegrar paciente ao cotidiano, minimizando sequelas físicas emocionais. Foram utilizados como...
Cumulative evidence suggests that moderate wine consumption exerts a cardioprotective effect. We investigated the occurrence of an antihypertensive effect alcohol-free hydroalcoholic grape skin extract (GSE) obtained from skins vinifera (Vitis labrusca) in experimental rodent hypertension models. The vasodilator GSE (polyphenols concentration 55.5 mg g(-1)) was also assessed isolated mesenteric vascular bed Wistar rats and antioxidant studied on lipid peroxidation hepatic microsomes. Oral...
Cigarette smoke (CS) causes pulmonary emphysema in humans and elastin degradation plays a key role its pathogenesis. Previous studies on CS-exposed animals have been equivocal not clearly demonstrated the progression of disease. In this study, morphometry was used to assess lung modifications alveolar septa, airspaces, elastic collagen fibers, macrophages. Male (n = 40) C57/BL6 mice were exposed 3 times/day, whole body, CS from three cigarettes for 10, 20, 30, or 60 days. Control groups 10)...
The interest in the mechanisms involved Toxoplasma gondii lipid acquisition has steadily increased during past few decades, but it remains not completely understood. Here, we investigated biogenesis and fate of droplets (LD) skeletal muscle cells (SkMC) their interaction with T. by confocal electron microscopy. We also evaluated whether infected SkMC modulates production prostaglandin E2 (PGE2), cytokines interleukin-12 (IL-12) interferon-gamma (INF-g), cyclooxygenase-2 (COX-2) gene...
O infarto agudo do miocárdio (IAM) é uma das principais causas de mortalidade global, exigindo intervenções rápidas para minimizar danos cardíacos. A reperfusão precoce, por meio angioplastia primária ou terapia trombolítica, fundamental reduzir complicações e melhorar o prognóstico. Em contextos com acesso limitado à intervenção percutânea, os trombolíticos tornam-se alternativa viável. Este estudo tem objetivo analisar impacto da trombólise na emergência, destacando seus benefícios,...
Este artigo investiga a evasão discente no curso de Zootecnia da UFVJM, Campus JK, Diamantina-MG, através uma pesquisa abrangente que combina revisão bibliográfica, estudo caso e Pesquisa Opinião com gestores do curso. A análise Opinião, realizada as três gestoras, revela percepções sobre os motivos estratégias para mitigar o problema. Os resultados indicam é um fenômeno multifacetado, influenciado pela descontinuidade acompanhamento acadêmico, falta diagnósticos precoces risco carência...
Two-kidney-one-clip (2K-1C) rats develop renovascular hypertension associated with endothelial dysfunction and elevated levels of oxidative stress. The role damage is unknown in vascular coupled 2K-1C hypertension. aims this study were to evaluate the effects chronic treatment a superoxide dismutase (SOD) mimetic (tempol) an inhibitor nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase (apocynin) on development hypertension, dysfunction, rats. sham-operated treated tempol...
The mechanisms involved in the cardioprotector effect of red wine have not yet been completely elucidated but probably an endothelium-dependent vasodilator action may play a significant role this effect. Experiments were undertaken to determine whether Brazilian (BRW) induces vasodilation mesenteric vascular bed (MVB) and antihypertensive was also assessed rats with NO-deficient hypertension. In MVB precontracted norepinephrine, BRW (alcohol-free lyophilized) long-lasting that is reduced by...
Alpinia zerumbet (K. Schum), a medicinal plant originated from West Asia, is used in the northeast and southeast of Brazil as infusions or decoctions diuretic, antihypertensive, antiulcerogenic. Experiments were undertaken to determine whether hydroalcoholic extract obtained leaves (AZE) induces vasodilation mesenteric vascular bed (MVB), an antihypertensive effect was also assessed rats with DOCA-salt hypertension. In MVB precontracted norepinephrine, AZE long-lasting endothelium-dependent...
Toxoplasma gondii is a protozoan pathogen of birds and mammals, including humans. The infective stage, the bradyzoite, lives within cysts, which occur predominantly in cells central nervous system skeletal cardiac muscles, characterizing chronic phase toxoplasmosis. In present study, we employed for first time primary mouse culture muscle (SkMC) infected with bradyzoites, as cellular model cystogenesis. interconversion bradyzoite tachyzoite was analyzed by immunofluorescence using 2...
Although the predilection for Toxoplasma gondii to form cysts in nervous system and skeletal heart muscles has been described more than fifty years, muscle cells (SkMCs) have not explored as a host cell type study Toxoplasma-host interaction investigate intracellular development of parasite. Morphological aspects initial events Toxoplasma-SkMC were analysed suggest that there are different processes protozoan adhesion invasion subsequent fate parasite inside parasitophorous vacuole (PV)....
Abstract Purpose To estimate inflammatory bowel disease (IBD) prevalence in Portugal from 2003 to 2007, and obtain disease, sex age specific estimates. Methods A pharmaco‐epidemiological approach based on intestinal anti‐inflammatory (IAI) drugs consumption was used. Proportion of patients taking IAI mean prescribed daily dose (PDD) were estimated a sample 513 IBD patients. Assumptions made about unknown parameters sensitivity analysis performed: drug compliance (80% base case; range 70–85%)...
Abstract In the present study we characterized titanium (Ti) surfaces submitted to different treatments and evaluated response of osteoblasts derived from human alveolar bone these surfaces. Five were evaluated: ground (G), chemical etched (G1‐HF for 60 s), sand blasted (SB‐Al 2 O 3 particles 65 μm), (SLA1‐HF s SLA2‐HF 13 s). Surface morphology was under SEM roughness parameters by contact scanning instrument. The presence Al detected EDS amount calculated digital analyses. Osteoblasts...
Leishmania amazonensis activates the NF-κB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated role of PI3K/Akt in p50/p50 activation effect on iNOS expression L. infection. The increased occupancy promoter infected macrophages was observed we demonstrated that both induction downregulation depended activation. Importantly, intracellular growth parasite also impaired during signalling inhibition knocked-down for Akt 1...
PURPOSE: To study the effect of remote ischemic preconditioning (RIPC) in ischemia-reperfusion (I/R) liver injury and expression IL-6 IL-10 a rat model. METHODS: Thirty-six male rats were divided three groups: Sham; I/R injury, 45 minutes lobar ischemia reperfusion; RIPC, six cycles four reperfusion on right hindlimb followed by reperfusion. Tissue blood samples collected after 1h 3h for histopathological study, plasma cytokines alanine aminotransferase (ALT) measurement. RESULTS: The...