A5027332945- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Fatty Acid Research and Health
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroendocrine regulation and behavior
- Heavy Metals in Plants
- Sleep and Wakefulness Research
- Infant Nutrition and Health
- High Altitude and Hypoxia
- Diet, Metabolism, and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Thermal Regulation in Medicine
- Liver Disease Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Thermoregulation and physiological responses
- Lipid metabolism and biosynthesis
- Complementary and Alternative Medicine Studies
- Neonatal Respiratory Health Research
- Cholesterol and Lipid Metabolism
- Therapeutic Uses of Natural Elements
Oregon Health & Science University
2016-2021
Neurological Surgery
2016-2021
Eli Lilly (United States)
2021
Universidade do Estado do Rio de Janeiro
2010-2018
Department of Physiological Sciences
2015
Tirzepatide (LY3298176), a dual GIP and GLP-1 receptor (GLP-1R) agonist, delivered superior glycemic control weight loss compared with GLP-1R agonism in patients type 2 diabetes. However, the mechanism by which tirzepatide improves efficacy how (GIPR) contributes is not fully understood. Here, we show that an effective insulin sensitizer, improving sensitivity obese mice to greater extent than agonism. To determine whether GIPR contributes, effect of WT Glp-1r–null mice. In absence...
The aim of this study was to investigate the effect a polyphenol-rich Açaí seed extract (ASE, 300 mg/kg-1d-1) on adiposity and hepatic steatosis in mice that were fed high-fat (HF) diet its underlying mechanisms based lipid metabolism oxidative stress. Four groups studied: C57BL/6 with standard (10% fat, Control), 10% fat + ASE (ASE), 60% (HF), (HF ASE) for 12 weeks. We evaluated food intake, body weight gain, serum glucose profile, cholesterol triacyglycerol (TG), expression pAMPK,...
Endogenous intestinal glucagon-like peptide-1 (GLP-1) controls satiation and glucose metabolism via vagal afferent neurons (VANs). Recently, VANs have received increasing attention for their role in brown adipose tissue (BAT) thermogenesis. It is, however, unclear whether VAN GLP-1 receptor (GLP-1R) signaling affects BAT thermogenesis energy expenditure (EE) this mechanism contributes to balance. First, we tested the effect of GLP-1R agonist exendin-4 (Ex4, 0.3 μg/kg ip) on EE these effects...
In urethane/α-chloralose anesthetized rats, electrical stimulation of cervical vagal afferent fibers inhibited the increases in brown adipose tissue sympathetic nerve activity and thermogenesis evoked by cold exposure, nanoinjection GABAA receptor antagonist, bicuculline, dorsomedial hypothalamus, N-methyl-D-aspartate rostral raphe pallidus. Vagus stimulation-evoked inhibition was prevented blockade ionotropic glutamate receptors termination site afferents nucleus solitary tract, antagonists...
Evidence from in vitro and animal studies indicates that conjugated linoleic acid (CLA) possesses anti-diabetic properties, which appear to be attributed cis-9, trans-11 CLA, the major CLA isomer ruminant fat. However, there is a shortage of addressing natural source. The present study aimed evaluate effects butter naturally enriched on parameters related glucose tolerance, insulin sensitivity dyslipidemia rats. Forty male Wistar rats were randomly assigned following dietary treatments (n =...
Within the central neural circuitry for thermoregulation, balance between excitatory and inhibitory inputs to dorsomedial hypothalamus (DMH) determines level of activation brown adipose tissue (BAT) thermogenesis. We employed neuroanatomical in vivo electrophysiological techniques identify a source excitation thermogenesis-promoting neurons DMH that is required cold defense fever. Inhibition median preoptic area (MnPO) blocked BAT thermogenic responses during both PGE2-induced fever...
We examined the long-term effects of protein restriction during puberty on function hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes in male rats. Male Wistar rats from age 30 to 60 days were fed a low-protein diet (4%, LP). A normal-protein (20.5%) was reintroduced 120 days. Control throughout life (NP). Rats or old killed. Food consumption, body weight, visceral fat deposits, lipid profile, glycemia, insulinemia, corticosteronemia, adrenocorticotropic...
To determine the role of neurons in ventral part lateral preoptic area (vLPO) CNS thermoregulation.In vivo electrophysiological and neuropharmacological were used to evaluate contribution vLPO regulation brown adipose tissue (BAT) thermogenesis muscle shivering urethane/chloralose-anaesthetized rats.Nanoinjections NMDA targeting medial (MPA) suppressed cold-evoked BAT sympathetic activity (SNA), reduced temperature (TBAT ), expired CO2 , mean arterial pressure (MAP), heart rate. Inhibition...
Litter size reduction during lactation is a good model for childhood obesity since it induces overnutrition and programming at adulthood. Adult offspring develop higher fat mass content, hyperinsulinemia insulin resistance, hypertension, lower HDL cholesterol, hyperphagia, leptin resistance. Leptin resistance often associated with hyperleptinemia. Although we observed SOCS3 STAT3 in the hypothalamus of rats raised small litters featuring central they showed unexpected normoleptinemia 180...
Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied effects yerba mate on hypothalamic changes leptin and insulin signalling, oxidative stress liver morphology metabolism postnatal early overfeeding (EO) Wistar rats. To induce EO, litter size was reduced to three pups per dam, litters with 10 dam were used as control (10 each). On day (PN) 150, EO offspring subdivided into EO+mate groups animals each), which treated water or tea [1 g/kg...
Synthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety this is controversial countries usage as food supplement not authorized. Changes insulinemic control serum lipids profile are potential negative effects related to consumption mixture. The present study aimed evaluate a diet on prevention obesity risk well side such insulin...
Rats raised in small litters (SL) are obese and hyperphagic. In the present study, we evaluated whether obesity is associated with changes mesocorticolimbic dopaminergic reward system these animals at adulthood. We also assessed anti-obesity effects of dietary calcium supplementation. To induce early overfeeding, were adjusted to three pups on postnatal day (PN)3 (SL group). Control kept 10 each until weaning (NL On PN120, SL subdivided into two groups: (standard diet) SL-Ca [SL...
The impairment of cold-evoked activation brown adipose tissue (BAT) in rats fed a high-fat diet (HFD) requires the activity vagal afferent to medial nucleus solitary tract (mNTS). We determined role transient receptor potential vanilloid 1 (TRPV1) mNTS, and dynorphin input median preoptic (MnPO) impaired BAT thermogenic response cold HFD-fed rats. levels some linoleic acid (LA) metabolites, which can act as endogenous TRPV1 agonists, were elevated NTS HFD compared with chow-fed In rats,...
Maternal protein restriction (PR) during lactation programs a lower body weight, hyperthyroidism, leptin resistance, and over-expression of receptor in the pituitary gland at adulthood. Because regulates energy homeostasis hypothalamus-pituitary-thyroid (HPT) axis, we evaluated adipocyte morphology, signaling pathway HPT axis vitro thyrotropin (TSH) response to adult progeny this model. At birth, dams were separated control diet with 23% or PR 8% protein. After weaning, offspring received...
Early weaning (EW) leads to overweight, visceral obesity, hyperleptinemia, and insulin resistance in adulthood. Treatment with Ilex paraguariensis (yerba mate) improves obesity these animals. Here, we evaluated the effects of chronic treatment yerba mate on redox balance liver morphology overweight early-weaned rats. To induce EW, wrapped dams bandages interrupt milk access during last 3 days lactation. Control pups (C) had free maternal for full 21 On postnatal day (PN) 150, EW offspring...
Rats overfed during lactation show higher visceral adipose tissue (VAT) mass and metabolic dysfunctions at adulthood. As both vitamin D glucocorticoids change adipogenesis, parameters related to metabolism action of these hormones in the adipocyte can be altered rats raised small litters (SL). We also studied antiobesity effects high calcium diet since it decreases fat obesity models. On postnatal day (PN) 3, litter size was adjusted 3pups/dam (SL) induce overfeeding. Control (NL) remained...
Abstract Undernutrition during brain development causes long lasting alterations in different neurotransmitter systems that may alter responses to psychoactive drugs. Despite the recognized effects of early undernutrition on cholinergic system, no evidence demonstrates influence this insult nicotine susceptibility has been reported. We investigated protein/calorie restriction lactation adolescent mice. Dams were randomly assigned one following groups: Control (C, 20 litters)—free access...
Early overnutrition (EO) during lactation leads to obesity, leptin resistance and lower thyroid hormone (TH) levels adulthood. To better understand the biological significance of this hypofunction, we studied long-term effects postnatal EO on both function hypothalamic–pituitary–thyroid (HPT) axis metabolism action TH. induce EO, litter size was reduced three pups per (small (SL) group) third day lactation. In controls (normal group), adjusted 10 litter. Rats were killed at PN180. TRH...