A5009432033- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Phytochemistry Medicinal Plant Applications
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Nitric Oxide and Endothelin Effects
- Natural Antidiabetic Agents Studies
- Pregnancy and preeclampsia studies
- Sodium Intake and Health
- Renal and Vascular Pathologies
- Exercise and Physiological Responses
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Antioxidants, Aging, Portulaca oleracea
- Agricultural and Food Sciences
- Diet and metabolism studies
- Selenium in Biological Systems
- Ginger and Zingiberaceae research
- Apelin-related biomedical research
- Metabolism, Diabetes, and Cancer
- Free Radicals and Antioxidants
- Tea Polyphenols and Effects
Universidade do Estado do Rio de Janeiro
2014-2025
The aim of this study was to investigate the effect a polyphenol-rich Açaí seed extract (ASE, 300 mg/kg-1d-1) on adiposity and hepatic steatosis in mice that were fed high-fat (HF) diet its underlying mechanisms based lipid metabolism oxidative stress. Four groups studied: C57BL/6 with standard (10% fat, Control), 10% fat + ASE (ASE), 60% (HF), (HF ASE) for 12 weeks. We evaluated food intake, body weight gain, serum glucose profile, cholesterol triacyglycerol (TG), expression pAMPK,...
A growing body of evidence suggests a protective role polyphenols and exercise training on the disorders type 2 diabetes mellitus (T2DM). We aimed to assess effect açaí seed extract (ASE) associated with diabetic complications induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type was feeding rats HF (55% fat) for 5 weeks single dose STZ (35 mg/kg i.p.). Control (C) Diabetic (D) animals were subdivided into four groups each: Sedentary, Training, ASE Training. (200 mg/kg/day)...
This study examined the effect of açaí (Euterpe oleracea Mart.) seed extract (ASE) on cardiovascular and renal alterations in adult offspring, whose mothers were fed a low-protein (LP) diet during pregnancy.Four groups rats fed: control (20% protein); ASE (200 mg/kg per day); LP (6% + protein ASE) pregnancy. After weaning, all male offspring sacrificed at 4 months old. We evaluated blood pressure, vascular function, serum urinary parameters, plasma kidney oxidative damage, antioxidant...
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by high-fat diet (HFD). C57/BL6 mice were fed standard (10% fat, control, GSE groups) or an HFD (60% high fat (HF), HF + GSE) with without (200 mg/kg/day) for 12 weeks. prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, resistin; deregulation leptin adiponectin...
The consumption of a high-fat diet can cause metabolic syndrome and induces host gut microbial dysbiosis non-alcoholic fatty liver disease (NAFLD). We evaluated the effect polyphenol-rich jaboticaba peel seed powder (JPSP) on community composition health in mouse model NAFLD. Three-month-old C57BL/6 J male mice, received either control (C, 10% lipids as energy, n = 16) or (HF, 50% 64) for nine weeks. HF mice were randomly subdivided into four groups (n 16 each group), three which (HF-J5,...
Alpinia zerumbet, a plant native to East Asia, is widely found on the Brazilian coast, where it used in folk medicine as an antihypertensive, diuretic, and anxiolytic. This study investigated effects of hydroalcoholic extract obtained from zerumbet leaves (AZE) cardiovascular changes oxidative status spontaneously hypertensive rats (SHR). SHR Wistar-Kyoto male rats, 90 days old, treated or not with AZE (50 mg/kg/day drinking water) for six weeks, were this study. Blood pressure (BP) was...
Previously, we have demonstrated that the seed of Euterpe oleracea Mart. (açaí) from Amazon region exerts vasodilator and antihypertensive actions. The aim our study was to assess effects oral chronic treatment with açaí extract (ASE, 300 mg·kg−1·d−1) on high-fat (HF) diet-induced metabolic syndrome (MS) in C57BL/6J mice. Four groups C57BL/6 mice were fed control diet (10% fat), ASE HF (60% + fat plus ASE) for 12 weeks. acetylcholine (ACh) nitroglycerine (NG) studied perfused mesenteric...
The current study evaluated the content and profile of phenolic compounds, in vitro antioxidant activity, role Nrf2-signaling pathway cellular activity açaí seed extract (ASE) H2O2-induced oxidative stress human endothelial cells (HUVEC). Seven compounds were quantified ASE by HPLC-DAD-MS, among which (−)-epicatechin (+)-catechin most abundant. exhibited a potent different assays. In HUVEC, decreased cytotoxicity, prevented migratory capacity loss stress. promoted up-regulation master...
The role of the renin-angiotensin system (RAS), oxidative stress, and inflammation on development obesity its comorbidities has been extensively addressed. Euterpe oleracea Mart. (açaí) seed extract (ASE), with antioxidant anti-inflammatory properties capable to modulate plasma renin levels, evidenced as a potential regulator body mass. We hypothesized that supplementation ASE might exert beneficial effects obesity-related white adipose tissue changes metabolic disorders by interfering local...
Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (açaí) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated renal protective effects hydroalcoholic extract obtained from açaí (ASE) fruits two-kidney, one-clip (2K1C) renovascular hypertension. Young male Wistar rats were used to obtain 2K1C sham groups. Animals received ASE (200 mg/(kg·day) drinking water) or vehicle for 40 days. We serum urinary parameters, structural...