A5021198287- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Nitric Oxide and Endothelin Effects
- Phytochemistry Medicinal Plant Applications
- Eicosanoids and Hypertension Pharmacology
- Sodium Intake and Health
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Agricultural and Food Sciences
- Renal and Vascular Pathologies
- Natural Antidiabetic Agents Studies
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipokines, Inflammation, and Metabolic Diseases
- Exercise and Physiological Responses
- Fatty Acid Research and Health
- Advanced Glycation End Products research
- Craniofacial Disorders and Treatments
- Renin-Angiotensin System Studies
- Free Radicals and Antioxidants
- Oral and Maxillofacial Pathology
Universidade do Estado do Rio de Janeiro
2013-2025
The aim of this study was to investigate the effect a polyphenol-rich Açaí seed extract (ASE, 300 mg/kg-1d-1) on adiposity and hepatic steatosis in mice that were fed high-fat (HF) diet its underlying mechanisms based lipid metabolism oxidative stress. Four groups studied: C57BL/6 with standard (10% fat, Control), 10% fat + ASE (ASE), 60% (HF), (HF ASE) for 12 weeks. We evaluated food intake, body weight gain, serum glucose profile, cholesterol triacyglycerol (TG), expression pAMPK,...
This study aimed to investigate the effect of resistant starch from green banana (GB) on steatosis and short-chain fatty acid (SCFAs) production in high fat diet-induced obesity mice. High-fat group (HFB) exhibited lower gains BM (body mass; −6%; P < 0.01) compared with diet (HF). Additionally, HFB mice showed reduction liver (−28%, 93% hepatic triacylglycerol (P HF-diet-fed In addition, protein abundance AMPKp/AMPK, HMGCoA-r FAS were downregulated livers 0.01), relatively ABCG8 ABCG5...
A growing body of evidence suggests a protective role polyphenols and exercise training on the disorders type 2 diabetes mellitus (T2DM). We aimed to assess effect açaí seed extract (ASE) associated with diabetic complications induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type was feeding rats HF (55% fat) for 5 weeks single dose STZ (35 mg/kg i.p.). Control (C) Diabetic (D) animals were subdivided into four groups each: Sedentary, Training, ASE Training. (200 mg/kg/day)...
Our aim was to investigate the role of oxidative stress in elastase-induced pulmonary emphysema. C57BL/6 mice were subjected pancreatic porcine elastase (PPE) instillation (0.05 or 0.5 U per mouse, i.t.) induce Lungs collected on days 7, 14, and 21 after PPE instillation. The control group sham injected. Also, treated with 1% aminoguanidine (AMG) inducible NO synthase (iNOS) knockout received (i.t.), lungs analyzed after. We performed bronchoalveolar lavage, biochemical analyses stress, lung...
Two-kidney-one-clip (2K-1C) rats develop renovascular hypertension associated with endothelial dysfunction and elevated levels of oxidative stress. The role damage is unknown in vascular coupled 2K-1C hypertension. aims this study were to evaluate the effects chronic treatment a superoxide dismutase (SOD) mimetic (tempol) an inhibitor nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase (apocynin) on development hypertension, dysfunction, rats. sham-operated treated tempol...
This study examined the effect of açaí (Euterpe oleracea Mart.) seed extract (ASE) on cardiovascular and renal alterations in adult offspring, whose mothers were fed a low-protein (LP) diet during pregnancy.Four groups rats fed: control (20% protein); ASE (200 mg/kg per day); LP (6% + protein ASE) pregnancy. After weaning, all male offspring sacrificed at 4 months old. We evaluated blood pressure, vascular function, serum urinary parameters, plasma kidney oxidative damage, antioxidant...
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by high-fat diet (HFD). C57/BL6 mice were fed standard (10% fat, control, GSE groups) or an HFD (60% high fat (HF), HF + GSE) with without (200 mg/kg/day) for 12 weeks. prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, resistin; deregulation leptin adiponectin...
Previously, we have demonstrated that the seed of Euterpe oleracea Mart. (açaí) from Amazon region exerts vasodilator and antihypertensive actions. The aim our study was to assess effects oral chronic treatment with açaí extract (ASE, 300 mg·kg−1·d−1) on high-fat (HF) diet-induced metabolic syndrome (MS) in C57BL/6J mice. Four groups C57BL/6 mice were fed control diet (10% fat), ASE HF (60% + fat plus ASE) for 12 weeks. acetylcholine (ACh) nitroglycerine (NG) studied perfused mesenteric...
The role of the renin-angiotensin system (RAS), oxidative stress, and inflammation on development obesity its comorbidities has been extensively addressed. Euterpe oleracea Mart. (açaí) seed extract (ASE), with antioxidant anti-inflammatory properties capable to modulate plasma renin levels, evidenced as a potential regulator body mass. We hypothesized that supplementation ASE might exert beneficial effects obesity-related white adipose tissue changes metabolic disorders by interfering local...
Alpinia zerumbet, a plant native to East Asia, is widely found on the Brazilian coast, where it used in folk medicine as an antihypertensive, diuretic, and anxiolytic. This study investigated effects of hydroalcoholic extract obtained from zerumbet leaves (AZE) cardiovascular changes oxidative status spontaneously hypertensive rats (SHR). SHR Wistar-Kyoto male rats, 90 days old, treated or not with AZE (50 mg/kg/day drinking water) for six weeks, were this study. Blood pressure (BP) was...