A5101666913- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastric Cancer Management and Outcomes
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
- Autoimmune and Inflammatory Disorders
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Diagnosis and treatment of tuberculosis
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Esophageal and GI Pathology
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Genetic factors in colorectal cancer
- IL-33, ST2, and ILC Pathways
Hospital Braga
2015-2025
Unidade Hospitalar de Bragança
2024-2025
Hospital da Senhora da Oliveira Guimarães
2024
Universidade do Porto
2023
Hospital de São João
2023
Stavros Niarchos Foundation
2021-2022
Joachim Herz Stiftung
2021-2022
Instituto Português de Oncologia Francisco Gentil
2022
National Council for Scientific and Technological Development
2017
Faculdade de Agudos
2017
Objective Histological remission is being increasingly acknowledged as a therapeutic endpoint in patients with UC. The work hereafter described aimed to evaluate the concordance between three histological classification systems—Geboes Score (GS), Nancy Index (NI) and RobartsHistopathologyIndex (RHI), well their association endoscopic outcomes faecal calprotectin (FC) levels. Design Biopsy samples from 377 UC were blindly evaluated using GS, NI RHI. results compared patients’ Mayo Endoscopic...
Abstract Flash glucose monitoring system (FGMS) is an improved subset of continuous with a recognized effectiveness on glycemic control, though validation in patients Liver Cirrhosis (LC) lacking. To evaluate the accuracy FGMS Type 2 Diabetes Mellitus (DM) and LC, prospective, case-control study was performed 61 ambulatory LC DM (LC group, n = 31) or (Control 30). During 14 days, 4 assessments per day self-monitoring blood (SMBG, reference value) followed by scanning. There were 2567 paired...
We evaluated expression of TLR2, TLR4 and proinflammatory genes [NF-κB, TNF-α, cyclooxygenase-2 (COX-2)] in liver samples patients different stages disease. Fifteen with unexplained transaminases elevation (reference group), 22 viral chronic hepatitis (hepatitis 14 virus-induced severe fibrosis/cirrhosis (cirrhosis group) 10 hepatocarcinoma (hepatocarcinoma were consecutively included the study. Quantification TLR4, NF-κB, TNF-α COX-2 mRNA was done by real-time RT-PCR TLR2 protein...
Summary Background Therapeutic drug monitoring is a powerful strategy known to improve the clinical outcomes and optimise healthcare resources in treatment of autoimmune diseases. Currently, most methods commercially available for quantification infliximab ( IFX ) are ELISA‐ based, with turnaround time approximately 8 h, delaying target dosage adjustment following infusion. Aim To validate first point‐of‐care device market – Quantum Blue Infliximab assay (Buhlmann, Schonenbuch, Switzerland)...
Abstract Background The use of oral iron in deficiency (ID) and ID anemia IBD is controversial. Its lower costs ease application have to be weighed against the fear side effects questions about its efficacy. aim this study was assess efficacy tolerability Sucrosomial® correcting IBD. As a secondary objective we aimed impact ID, disability Methods This prospective bicentric study. patients diagnosed with or between november 2022 2023 treated were included. Half physicians instructed prescribe...
Abstract Background Corticosteroids (CS) are effective in induction of remission inflammatory bowel disease (IBD), but should be used sparingly, given their unfavourable safety profile. In fact, CS excess has been incorporated quality care standards IBD, highlighting the importance auditing use. A sparing strategy is frequently recommended due to risk side effects, its consequences IBD outcomes have less studied. Our primary aim was evaluate current use and patients, compare them with a...
Abstract Background The Urgency-Numeric Rating Scale (NRS) is a scale that assesses the severity of bowel urgency (BU), common symptom in ulcerative colitis (UC) associated with significant morbidity. aim this study was to translate and validate into Portuguese, as well assess prevalence BU cohort UC patients and, those clinical remission, evaluate its relation endoscopic histological activity manometric changes. Methods After translation Urgency-NRS seen at outpatient clinic were asked...
Mucosal healing and histological remission are different targets for patients with ulcerative colitis, but both rely on an invasive endoscopic procedure. This study aimed to assess faecal calprotectin neutrophil gelatinase B–associated lipocalin as biomarkers disease activity in asymptomatic colitis patients. was a multicentric cross-sectional including 371 patients, who were classified according their scores. These results evaluated alongside the levels of biomarkers. Macroscopic lesions...
The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker a key component disease monitoring. Our main aims were to compare two indexes-the continuous Geboes score [GS] the Robarts Histopathology index [RHI]-regarding their definitions response, ability faecal calprotectin [FC] levels discriminate between these statuses. This was analysis three prospective cohorts including 422 previously enrolled other...
Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such isolated endoscopic (IER) or radiologic (IRR) may also be acceptable options the long-term.Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five-year rates of hospitalization, surgery, use steroids, escalation were compared between with TR, IER, IRR, no...
Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose this study was to examine two close independent southern European UC populations from 2 bordering countries observe how demographic clinical characteristics patients can influence the severity UC. A cross-sectional conducted during a 15-month period (September 2005 December 2006) based on data Web registries patients. Patients were stratified according Montreal Classification...
About 70 loci are associated with susceptibility to Crohn's disease (CD), particularly in pathways of innate immunity, autophagy, and pathogen recognition. Phenotype-genotype associations inconsistent.CD polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, TLR4 rs4986790 were genotyped a Portuguese population (511 CD patients, 626 controls) assessed for association clinical characteristics.There is significant the...
Evidence has been supporting that histological activity of ulcerative colitis [UC] relevance for the prediction clinical outcomes in UC patients, such as relapse. In this study, we aimed to compare two indexes-the continuous Geboes score [GS] and Nancy index [NI] -regarding their definitions remission response, determine ability faecal calprotectin [FC] levels discriminate between these statuses according NI. A large cohort patients [N = 422] who were previously enrolled other studies was...
Abstract Purpose To estimate inflammatory bowel disease (IBD) prevalence in Portugal from 2003 to 2007, and obtain disease, sex age specific estimates. Methods A pharmaco‐epidemiological approach based on intestinal anti‐inflammatory (IAI) drugs consumption was used. Proportion of patients taking IAI mean prescribed daily dose (PDD) were estimated a sample 513 IBD patients. Assumptions made about unknown parameters sensitivity analysis performed: drug compliance (80% base case; range 70–85%)...
Abstract Background Serum dipeptidyl peptidase 4 (DPP-4) has drawn particular interest as a biomarker in inflammatory bowel disease (IBD), this protease inactivates several peptides that participate the cascade. Methods Two prospectively recruited cohorts consisting of 195 patients (101 had Crohn’s [CD] and 94 ulcerative colitis [UC]) were evaluated using clinical indexes followed up to assess for treatment escalation. Sixty-eight underwent endoscopic evaluation at baseline. In second cohort...
Given the heterogeneous nature of Crohn's disease (CD), our aim was to apply Montreal Classification a large cohort Portuguese patients with CD in order identify potential predictive regarding need for medical and/or surgical treatment.A cross-sectional study used based on data from an on-line registry CD.Of 1692 5 or more years disease, 747 (44%) were male and 945 (56%) female. On multivariate analysis A2 group independent risk factor steroids (odds ratio [OR] 1.6, 95% confidence interval...
Recently, the Inflammatory Bowel Disease-Disability Index (IBD-DI) was developed to assess disability in inflammatory bowel disease (IBD). Our aim validate Portuguese version of IBD-DI according COnsensus-based Standards for selection health Measurement INstruments (COSMIN) recommendations.After translation into Portuguese, administered by two interviewers IBD patients at baseline and after 4 weeks months. We evaluated reliability (internal consistency, test-retest, inter-rater measurement...
Background: Anaemia is the most common complication in patients with inflammatory bowel disease (IBD). This study aims to assess prevalence of anaemia IBD and know its characteristics regard main clinical features. Methods: An observational cross-sectional multicentre was conducted. We included all who had an appointment at 15 participating centres during period 1 month, met following selection criteria: age ≥18, diagnosis IBD. Disease activity evaluated by Harvey-Bradshaw Index (HBI) for...
INTRODUCTION: Inflammatory bowel disease (IBD) affects people from all age categories worldwide. Although the incidence of is stabilizing or decreasing in most Western world countries, its prevalence still increasing because rise life expectancy and better management. This work intends to identify trends related IBD nationwide, analyzing regional, sex, distributions. METHODS: Data were provided by Portuguese Shared Services Ministry Health. study consisted a retrospective analysis first...
Inflammatory bowel disease (IBD) may be associated with a wide range of hepatobiliary manifestations. This study aimed to characterize the spectrum disorders in patients IBD who underwent liver biopsy for sustained abnormal function tests (LFT).A retrospective was performed all between January 2010 and December 2020 LFT (at least 6-month duration).A total 101 were included, mostly male (62.4%), mean age 44.4±13.3 years. The most common type Crohn's (61.4%). Median time interval 14 (7-36)...