A5005008786- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Pulmonary Hypertension Research and Treatments
- Apelin-related biomedical research
- Immune Response and Inflammation
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac Fibrosis and Remodeling
- Helicobacter pylori-related gastroenterology studies
- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Cardiovascular and exercise physiology
- Peroxisome Proliferator-Activated Receptors
- Exercise and Physiological Responses
- Veterinary medicine and infectious diseases
- Public Health in Brazil
- HIV/AIDS oral health manifestations
- Alcoholism and Thiamine Deficiency
- Environmental Sustainability and Education
- Reservoir Engineering and Simulation Methods
- Aviation History and Innovations
- Liver Disease Diagnosis and Treatment
Pontifical Catholic University of Rio de Janeiro
2023
Universidade do Porto
2010-2020
Universidade Federal de Uberlândia
2013
Instituto de Filosofía
2013
Weatherford College
2010
We investigated the endogenous production of apelin and cardiac pulmonary effects its chronic administration in monocrotaline (MCT)-induced hypertension (PH). Male Wistar rats were injected with MCT (60 mg/kg sc) or vehicle ( day 0). One week later, these animals randomly treated during 17 days pyroglutamylated apelin-13 (Pyr-AP13; 200 μg·kg −1 ·day ip) a similar volume saline, resulting four groups: sham n = 11), sham-AP 16), MCT-AP 13). On 25, right ventricular (RV) left (LV) hemodynamic...
Calcium ions play a pivotal role in matching energy supply and demand cardiac muscle. Mitochondrial calcium concentration is lower animal models of heart failure with reduced ejection fraction (HFrEF), but limited information available about mitochondrial handling preserved (HFpEF).We assessed Ca2+ intact cardiomyocytes from Zucker/fatty Spontaneously hypertensive F1 hybrid (ZSF1)-lean (control) ZSF1-obese rats, metabolic risk-related model HFpEF. A mitochondrially targeted indicator...
We evaluated expression of TLR2, TLR4 and proinflammatory genes [NF-κB, TNF-α, cyclooxygenase-2 (COX-2)] in liver samples patients different stages disease. Fifteen with unexplained transaminases elevation (reference group), 22 viral chronic hepatitis (hepatitis 14 virus-induced severe fibrosis/cirrhosis (cirrhosis group) 10 hepatocarcinoma (hepatocarcinoma were consecutively included the study. Quantification TLR4, NF-κB, TNF-α COX-2 mRNA was done by real-time RT-PCR TLR2 protein...
Abstract Background Toll‐like receptors ( TLR ) are essential for H elicobacter pylori HP recognition. Their role in the progression of gastric lesions leading to cancer is not established. Aim To evaluate first time humans expression 2, 4, and 5, as well other related molecules entire sequence lesions. Methods Biopsy samples (n = 80, 48% +) from normal mucosa, gastritis, metaplasia, dysplasia or adenocarcinoma were obtained 44 patients. m RNA quantification T oll‐interacting protein TOLLIP...
Background Animal data suggest that Toll-like receptors (TLR) may play an important role in colon carcinogenesis. Studies humans to support hypothesis are scarce. Aim To evaluate the expression of TLR2, TLR4 and TLR5, several other related molecules, different human colonic lesions. Methods Colon biopsy samples from normal mucosa, mucosa adjacent lesion, adenoma or sporadic carcinoma were obtained 35 consecutive patients undergoing colonoscopy. Quantification TLR4, Toll-interacting protein...
"Obesity cardiomyopathy" effects have been widely described; however, the specific contribution of metabolic changes and altered adipokine secretion are still uncharacterized. Moreover, a diagnosis based on body mass index might not be most accurate to identify increased adiposity its outcomes. In this study, we aimed determine impact Western-type diet [hypercaloric (HCD)] ingestion biventricular structure function, as well endocrine that occur before establishment overt obesity. Wistar rats...
Background: Alcoholic chronic liver disease (ACLD) is a common form of acquired immunodeficiency. Aim: To evaluate ex vivo toll-like receptor (TLR) 2 and TLR4 innate immune response in stable ACLD. Methods: Blood was collected from 26 males with ACLD 17 controls. Serum used for lipopolysaccharide (LPS), sCD14, LPS-binding protein (LBP), tumour necrosis factor-alpha (TNF-α) interleukin 10 (IL-10) quantification. Peripheral blood monocytes (PBM) expression TLR2 determined by flow cytometry....
To investigate the effects of left ventricular (LV) pressure overload and diabetes on apelinergic system.Pressure was established in rats by supra-renal aortic-banding. Six weeks later, induced streptozotocin (65 mg/kg, intraperitoneal), resulting four groups: sham, banded (BA), diabetic (DM) diabetic-banded (DM-BA). Twelve LV function structure were evaluated echocardiography biopsies plasma samples collected. Furthermore, LV-endomyocardial procured from aortic stenosis mitral patients...
BackgroundStructural and functional changes involved in cardiac injury induced by diabetes mellitus, pressure-overload, or both conditions were evaluated.
Heart failure with preserved ejection fraction (HFpEF) is recognised as an important cause of cardiovascular mortality and morbidity, accounting for approximately 50% heart cases. Metabolic-related complications, such obesity, have been associated the pathophysiology this complex syndrome. The anatomic proximity between cardiac visceral adipose tissue (CVAT) myocardium has drawing attention due to its potential pathogenic role in diseases. Thus, we aimed characterise phenotypic proteomic...
Despite pulmonary arterial hypertension (PAH) directly affects the right ventricle (RV), important structural, functional, and molecular changes also occur in left (LV). The objective of our study was to analyze hypothetical cardioprotective effects exercise preconditioning on LV rats with monocrotaline (MCT)-induced PAH.Forty male Wistar were randomly separated sedentary (SED) trained group (EX; running sessions 60 min/day, 5 days/wk, at 25 m/min, for 4 weeks). After weeks, animals injected...