A5078589292- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Advanced Proteomics Techniques and Applications
- Nutrition and Health in Aging
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Oral microbiology and periodontitis research
- S100 Proteins and Annexins
- Intraperitoneal and Appendiceal Malignancies
- Exercise and Physiological Responses
- Paraoxonase enzyme and polymorphisms
- Cardiac Ischemia and Reperfusion
- Cell death mechanisms and regulation
- Sperm and Testicular Function
- ATP Synthase and ATPases Research
- Physical Activity and Health
- Cardiomyopathy and Myosin Studies
Universidade do Porto
2014-2025
University of Aveiro
2011-2019
Celulose Beira Industrial (Portugal)
2014
Deleted Institution
2014
Selangor Business School
2014
In the present study, we applied iTRAQ-based quantitative approach to explore salivary proteome and peptidome profile in selected subjects with type 1 diabetes, without microvascular complications, aiming identify disease-related markers. From a total of 434 distinct proteins, bactericidal/permeability-increasing protein-like pancreatic adenocarcinoma up-regulated factor were found higher levels saliva all patients while increased content other proteins like alpha-2-macroglobulin, defensin...
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several types cancer. Despite its efficacy, DOX can potentially cause fatal adverse effects, like cardiotoxicity. This work aimed to assess role inflammation DOX-treated infant and adult mice possible link underlying Two groups CD-1 male different ages (infants or adults) were subjected biweekly administrations, reach cumulative dose 18.0 mg/kg, which corresponds approximately humans 100.6 mg/m2 for infants...
The present study aimed to test whether a chronic intermittent workload could induce an adaptive cardiac phenotype Chronic induced features of hypertrophy This was paralleled by protection against acute pressure overload insult heart may adapt favourably balanced demands, regardless the nature stimuli. submitting healthy and tolerable amounts workload, independently its nature, result in phenotype. Male Wistar rats were subjected treadmill running (Ex) (n = 20), with dobutamine (ITO) (2 mg...
Conflicting evidence exists regarding the superiority of Polarized Training (POL) vs other training intensity distribution models. Compare POL threshold (THR) on V̇O2max, endurance capacity (EC) and mitochondrial function. Fifteen male Wistar rats (336.1 ± 30.4 g) were divided in: (n = 5), THR 5) or control (CON; n groups. V̇O2max (indirect calorimetry) EC (treadmill exhaustion test) determined at baseline four eight-weeks training. consisted 80% running volume 60%V̇O2max 20% 90%V̇O2max...
Infertility is a clinical disorder affecting approximately 15% of reproductive-aged couples worldwide. Recently, the influence oxidative stress (OS) in decreased semen quality has been discussed. OS corresponds to an imbalance between oxidants and antioxidants defenses, present organism. High levels reactive oxygen species (ROS) damage biomolecules sperm cells may lead loss membrane integrity, DNA fragmentation or even death by apoptosis. This study aimed evaluate correlation human clinic...
Abstract Aim Exercise training has been suggested as a non‐pharmacological approach to prevent skeletal muscle wasting and improve function in cancer cachexia. However, little is known about the molecular mechanisms underlying such beneficial effect. In this study, we aimed to, firstly, examine contribution of TWEAK signalling cancer‐induced and, secondly, evaluate whether long‐term exercise alters prevents wasting. Methods Female Sprague‐Dawley rats were randomly assigned control groups....
Mitoxantrone (MTX) is a pharmaceutical drug used in the treatment of several cancers and refractory multiple sclerosis (MS). Despite its therapeutic value, adverse effects may be severe, namely frequently reported cardiotoxicity, whose mechanisms need further research. This work aimed to assess if inflammation or oxidative stress-related pathways participate cardiotoxicity MTX, using mouse as an animal model, at two different age periods (infant adult mice) relevant cumulative doses....
Moderate physical activity has traditionally been associated with the improvement of cardiac function and, consequently, extension life span. Mitochondria play a key role in adaptation heart muscle to exercise-related metabolic demands. In order disclose molecular mechanisms underlying beneficial effect lifelong function, we performed label-free quantitative mass spectrometry-based proteomics Sprague-Dawley rat mitochondrial proteome and phosphoproteome. Our data revealed that 54 weeks...
Cancer associated body wasting is the cause of physical disability, reduced tolerance to anticancer therapy and survival cancer patients and, similarly cancer, its incidence increasing. There no cure for this clinical condition, pathophysiological process involved largely unknown. Exercise training appears as gold standard non-pharmacological management syndrome. Herein we used a lipidomics approach based on liquid chromatography coupled with high-resolution mass spectrometry (LC-HR-MS)...
Abstract Doxorubicin (DOX) is a topoisomerase II inhibitor used in cancer therapy. Despite its efficacy, DOX causes serious adverse effects, such as short- and long-term cardiotoxicity. This work aimed to assess the cardiotoxicity of role inflammation antioxidant defenses on that mice model. Adult CD-1 male received cumulative dose 9.0 mg/kg (2 biweekly intraperitoneal injections (ip), for 3 weeks). One week (1W) or 5 months (5M) after last administration, heart was collected. DOX,...