A5084173639- Bladder and Urothelial Cancer Treatments
- Cancer Research and Treatments
- Urinary and Genital Oncology Studies
- Polyamine Metabolism and Applications
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Glutathione Transferases and Polymorphisms
- Estrogen and related hormone effects
- Ovarian cancer diagnosis and treatment
- Ergonomics and Human Factors
- Parasites and Host Interactions
- Oral and Craniofacial Lesions
- Oral Health Pathology and Treatment
- Parathyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- Computational Fluid Dynamics and Aerodynamics
- Colorectal and Anal Carcinomas
- Oral and gingival health research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Multiple Sclerosis Research Studies
- Occupational Health and Safety in Workplaces
University of Lausanne
2025
University Hospital of Lausanne
2025
Ludwig Cancer Research
2025
Fernando Pessoa University
2012-2024
IPO Porto
2003-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2023
Instituto Português de Oncologia de Coimbra Francisco Gentil
2021
Dartmouth College
2019
Instituto Português de Oncologia Francisco Gentil
2003-2017
Universidade do Porto
1985-2015
Little is known on the expression of tumour‐associated carbohydrate antigen sialyl‐Tn (STn), in bladder cancer. We report here that 75% high‐grade tumours, presenting elevated proliferation rates and high risk recurrence/progression expressed STn. However, it was mainly found non‐proliferative areas tumour, namely cells invading basal muscle layers. STn also tumour‐adjacent mucosa, which suggests its dependence a field effect tumour. Furthermore, not by normal urothelium, demonstrating...
Muscle invasive bladder cancer (MIBC, stage ≥T2) is generally associated with poor prognosis, constituting the second most common cause of death among genitourinary tumours. Due to high molecular heterogeneity significant variations in natural history and disease outcome have been observed. This has also delayed introduction personalized therapeutics, making advanced almost an orphan terms treatment. Altered protein glycosylation translated by expression sialyl-Tn antigen (STn) its precursor...
Este estudo abordou a ergonomia no ambiente escolar, destacando suas contribuições para o bem-estar físico e psicológico dos alunos, além da melhoria do desempenho acadêmico. A pesquisa evidenciou que adequação mobiliário, aliada elementos como iluminação, ventilação temperatura, é essencial prevenir problemas musculoesqueléticos potencializar concentração motivação. integração de tecnologias educacionais, dispositivos móveis realidade virtual, reforça necessidade práticas ergonômicas...
Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these have strong propensity to recur and about 1/3 them compared disease progression. Histological assessment is not sufficiently discriminator in predicting prognosis; therefore, we decided evaluate the prognostic significance p53 Ki-67 immunoexpression low-grade (GI-II) USPC order predict potential outcome tumors. P53 were studied function recurrence-free...
Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic clinical studies related to cancer cell, cell biology, oncology, radiation therapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neuro-oncology, etc.
The purpose of this study was to determine the efficacy a combination gemcitabine and sirolimus in mouse model invasive bladder cancer.Gemcitabine (50 mg/kg) (1.5 were administered animals previously exposed N-butyl-N-4(hydroxybutyl)nitrosamine drinking water. Tumour development determined by histopathological evaluation.Both drugs well tolerated animals. incidence lesions mice treated with lower comparison those not treated, however result statistically significant. cancer (20%) than (54%)...
5021 Background: In p with locally-advanced bladder cancer, neoadjuvant chemotherapy followed by cystectomy improves survival compared to surgery alone, especially in attaining a pathological response (pT0–1N0M0). However, at present no clinical markers are available predict cancer. BRCA1 mRNA expression has been associated chemosensitivity and lung ovarian cancer (Taron et al. 2004; Quinn 2007) could be useful predictive marker as well. Methods: We analyzed quantitative PCR tumor biopsies...
Multiple sclerosis is an autoimmune disease of the central nervous system with neurological and motor symptoms that affect orofacial region. The aim this work to present a patient lacks three classic manifestations but has other less common clinical alterations.A 49-year-old female diagnosed long-term relapsing-remitting multiple visited dentist complaining mild persistent pain including temporomandibular joint not specific any tooth. She presented mucosal irritation, xerostomia, halitosis,...
(1) Background: Walnut consumption has been associated with having a positive effect on controlling and/or reducing the co-morbidities cardiovascular disease (CVD). The effects of consuming walnuts Portuguese origin risk factors related to CVD were evaluated by measuring glucose, urea, TC, HDL-C, LDL-C, TG, AST, and ALT levels, anthropometric profiles, blood pressure. (2) Methods: This trial study involved 24 volunteers, both female (n = 15) male 9), from Fernando Pessoa University, Porto....
e16013 Background: Epidemiological and molecular findings suggest that estrogen may play a role in bladder carcinogenesis urogenital schistosomiasis (UGS). Methods: A comprehensive analysis of expression receptors (ER) urothelial carcinomas (UC), n = 80 from non-infected patients UGS-related carcinoma (BlaCa) 27 was undertaken. I vitro, we evaluated the effect estradiol (E2) anti-estrogens on survival human BlaCa cells. In addition, dynamics simulations are ongoing to assess ability...
Abstract Issue The World Health Organization considers viral hepatitis a public health problem and aims to eliminate it as threat by 2030, reducing incidence 90% mortality 65%. To achieve these goals, the National Program for Viral Hepatitis recommends screening of at least once in lifetime. However, this is not widespread practice. Description Micro-elimination an effective, efficient, cost-effective intervention addressing chronic specific geographic areas. ‘Hep-ØN’ project reduce...