A5060121243- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Urologic and reproductive health conditions
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Multiple and Secondary Primary Cancers
- Gastric Cancer Management and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Mechanisms and Therapy
- Viral-associated cancers and disorders
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
Hospital Universitari Germans Trias i Pujol
2010-2024
European Association of Urology
2023-2024
Universitat Autònoma de Barcelona
2010
Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, basal/squamous (BASQ)-like tumors present more advanced disease and have worse prognosis. Transcriptomics-defined tumor subtypes are associated response to NAC.
Background and objectiveThe European, prospective, multicenter SATURN registry was developed to analyze surgical devices for male stress urinary incontinence. The primary objective is the cure rate during follow-up.MethodsEfficacy, complications, patient-reported outcomes, prognostic factors are being analyzed at various intervals 10-yr follow-up. results 1-yr follow-up presented here.Key findings limitationsThe cohort included 1046 patients (mean age 70 yr) from 28 centers in nine...
Surgery for male incontinence with artificial urinary sphincters and slings (SATURN) is a prospective, multicentre registry (observational cohort) stress surgery to collect prospective data from multiple European centres surgeons, evaluate the short- long-term success impact on quality of life.
5021 Background: In p with locally-advanced bladder cancer, neoadjuvant chemotherapy followed by cystectomy improves survival compared to surgery alone, especially in attaining a pathological response (pT0–1N0M0). However, at present no clinical markers are available predict cancer. BRCA1 mRNA expression has been associated chemosensitivity and lung ovarian cancer (Taron et al. 2004; Quinn 2007) could be useful predictive marker as well. Methods: We analyzed quantitative PCR tumor biopsies...
Pelvic lymph node dissection (PLND) is the most accurate procedure for (LN) staging in prostate cancer (PCa) patients. LN sectioning and hematoxylin eosin (H&E) staining of at least one slice remains gold standard evaluation, potentially leading to misdetection small metastatic focus. Entire analysis possible with One-Step Nucleic Acid Amplification (OSNA) by detecting cytokeratin 19 (CK19) mRNA as a surrogate invasion. This study aimed compare postoperative performance OSNA pooling...
Background and objective Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopathological variables can identify patients likely to respond, highlighting need for predictive biomarkers. We sought a signature NAC integrating clinical score, taxonomic subtype, gene expression. Material methods From 1994 2014, pre-treatment tumor...
ABSTRACT Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). Because not all benefit from treatment, NAC has been widely applied in clinical setting. There is strong evidence, based on retrospective studies, that Basal/Squamous (BASQ)-like tumours present more advanced disease and have worse prognosis; global transcriptomics can identify tumour subtypes associated response to NAC. We aimed investigate whether...
4579 Background: Cystectomy remains the standard treatment in MIBC and only a minority of p are treated with neoadjuvant chemotherapy, suggesting that predictive markers chemotherapy outcome needed. Low BRCA1 mRNA expression is associated an improvement survival bladder cancer cisplatin-based chemotherapy. However, function can be modulated by other DNA repair genes. RAP80 required for accumulation to sites breaks, cells depleted exhibit hypersensitivity irradiation. AEG-1 induce cause...