A5016719534- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Hormonal and reproductive studies
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Radiomics and Machine Learning in Medical Imaging
- Sexual Differentiation and Disorders
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Pelvic floor disorders treatments
- Renal and related cancers
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Pharmacological Effects and Assays
- MRI in cancer diagnosis
- Extracellular vesicles in disease
- Medical Imaging Techniques and Applications
- AI in cancer detection
- Muscle metabolism and nutrition
- Cardiovascular Disease and Adiposity
- Cancer Mechanisms and Therapy
- Health Systems, Economic Evaluations, Quality of Life
- Pediatric Urology and Nephrology Studies
Vall d'Hebron Hospital Universitari
2015-2025
Vall d'Hebron Institut de Recerca
2013-2025
Universitat Autònoma de Barcelona
2015-2024
Hospital Del Mar
2021
Hospital del Mar Research Institute
2021
Municipal Institute for Medical Research
2021
Hebron University
2021
Universitat de Barcelona
2015
Hospital Valle del Nalón
2013
Associação de Pais e Amigos dos Excepcionais de São Paulo
2012
Extracellular vesicles (EVs) secreted by tumors are abundant in plasma, but their potential for interrogating the molecular features of through multi-omic profiling remains widely unexplored. Genomic and transcriptomic circulating EV-DNA EV-RNA isolated from vitro vivo models metastatic prostate cancer (mPC) reveal a high contribution tumor material to EV-loaded DNA/RNA, validating findings two cohorts longitudinal plasma samples collected patients during androgen receptor signaling...
// Tamara Sequeiros 1 , Marina Rigau Cristina Chiva 2, 3 Melania Montes Iolanda Garcia-Grau Marta Garcia Sherley Diaz 4 Ana Celma 5 Irene Bijnsdorp 6 Alex Campos 8 Primiano Di Mauro 9 Salvador Borrós Jaume Reventós 10, 11 Andreas Doll Rosanna Paciucci Michiel Pegtel 7 Inés de Torres 1, Eduard Sabidó Juan Morote Mireia Olivan Group of Biomedical Research in Urology, Vall d'Hebron Institute (VHIR) and Universitat Autònoma Barcelona (UAB), Barcelona, Spain 2 Proteomics Unit, Centre Regulació...
A new and externally validated MRI-PM for csPCa was developed in the metropolitan area of Barcelona, a web-RC designed with option selecting probability threshold. The development cohort comprised 1486 men scheduled to undergo 3-tesla multiparametric MRI (mpMRI) guided and/or systematic biopsies one academic institution Barcelona. external validation 946 whom same diagnostic approach carried out as cohort, two other institutions area. CsPCa detected 36.9% 40.8% (p = 0.054). under curve mpMRI...
What's known on the subject? and What does study add? Metabolic syndrome can identify patients at high risk of cardiovascular disease. The prevalence metabolic is increasing worldwide associated with increased age, obesity hypogonadism. association between prostate cancer development has not been studied comprehensively, published studies report divergent results. This indicates that tumours detected in men are more aggressive than those without this condition. Objective To further examine (...
To evaluate the effects of holmium laser enucleation prostate (HoLEP) on sexual function.A retrospective analysis 202 sexually active patients who underwent HoLEP was performed. Patients were assessed at baseline and 3 12 months post-HoLEP. Evaluations included uroflowmetry symptom questionnaires (five-item version International Index Erectile Function [IIEF-5], ICIQ-male matters associated with LUTS [ICIQ-MLUTSsex], American Urological Association score [AUA-SS], single-question quality...
To validate the Barcelona magnetic resonance imaging predictive model (BCN-MRI PM) in men with pre-biopsy multiparametric MRI (mpMRI) reported Prostate Imaging Reporting and Data System (PI-RADS) v2.1, followed by transrectal transperineal prostate biopsies.
Objective: This study compares machine learning (ML) and logistic regression (LR) algorithms in developing a predictive model for sPCa using the seven variables from Barcelona (BCN-MRI) model. Method: A cohort of 5005 men suspected having PCa who underwent MRI targeted and/or systematic biopsies was used training, testing, validation. feedforward neural network (FNN)-based SimpleNet (GMV) regression-based (BCN) were developed. The models evaluated discrimination ability, precision-recall,...
Objective: To compare the efficacy of transrectal and transperineal prostate-guided biopsies to magnetic resonance imaging (MRI) index lesions in detecting clinically significant prostate cancer (csPCa), evaluate role systematic biopsies. Methods: This prospective multicenter trial, conducted early detection program csPCa Catalonia (Spain) between 2021 2023, involved 4,029 men suspected ha-ving PCa who underwent multiparametric MRI followed by guided From this cohort, 1,376 with reported...
Background: A transperineal approach to prostate biopsy is now recommended reduce the risk of infectious complications associated with transrectal route. Our aim compare efficacy transrectal- and transperineal-guided biopsies involving magnetic resonance imaging (MRI) index lesions in detecting significant cancer (sPCas), evaluate role systematic biopsies. Methods: In a prospective multicenter trial conducted an opportunistic early detection program for sPCa Catalonia (Spain), between 2021...
This study compares machine learning and logistic regression algorithms in developing a predictive model for sPCa using the seven variables from Barcelona (BCN-MRI) model. A cohort of 5,005 men suspected having PCa who underwent MRI, targeted and/or systematic biopsies was used training, validation testing. Feedforward Neural Network (FNN) SimpleNet-based (GMV) regression-based (BCN) were developed. The models evaluated discrimination ability, net benefit clinical utility. Both demonstrated...
The aim of this study was to analyze the relationship between statin use along with serum cholesterol levels and prostate cancer (PCa) detection aggressiveness. Statin users three years or more (SC) were assessed in 2408 men scheduled for biopsy. SC classified as normal (NSC: <200 mg/dL) high (HSC: >200 mg/dL). High-grade PCa (HGPCa) considered if Gleason score greater than 7. comprised 30.9% those studied. rate 31.2% on statins 37% non-statin (p < 0.006). 26.3% NSC 40.6% HSC...
A predictive model including age, PCa family history, biopsy status (initial vs repeat), DRE (normal abnormal), serum prostate-specific antigen (PSA), and prostate volume ca-tegory was developed to stratify initial suspicion in 1486 men with PSA > 3 ng/mL and/or abnormal DRE, whom mpMRI followed; 2- 4-core TRUS-guided biopsies where Prostate Imaging Report Data System (PI-RADS) lesions 12-core TRUS systematic were performed one academic institution between 1 January 2016−31 December 2019....
Nowadays prostate cancer is the most common solid tumor in men from industrialized countries and second leading cause of death. At ages when PCa usually diagnosed, mortality related to cardiovascular morbidity high; therefore, at risk for frequently receive chronic lipid-lowering antiplatelet treatment. The aim this study was analyze how treatment with statins, aspirin, their combination influenced detection. tumorigenic properties these treatments were evaluated by proliferation, colony...
Prostate Imaging-Reporting and Data System (PI-RADS) category 3 is a challenging scenario for detection of clinically significant prostate cancer (csPCa) some tools can improve the selection appropriate candidates biopsy.
Proliferative inflammatory atrophy (PIA) has been involved in prostatic carcinogenesis. However, little is known about the clinical significance of a PIA finding biopsies (PBs). The aim this study to determine incidence prostate (PBs), its association high-grade intraepithelial neoplasia (HGPIN), cancer (PCa), and tumor aggressiveness.Prospective observational lesion 528 extended PBs 200 radical prostatectomy specimens (RPS).PIA, HGPIN, PCa incidence, Gleason score, pathologic stage...
To assess of the clinical performance Proclarix® (a novel Conformité Européenne [CE]-marked biomarker test aiding in identification clinically significant prostate cancer [csPCa]) alone or combination with multiparametric magnetic resonance imaging (mpMRI) to predict csPCa (International Society Urological Pathology Grade Group ≥2).The study included blood samples from 721 men undergoing mpMRI followed by biopsy at University College London, and Vall d'Hebron Hospital, Barcelona. Samples...
Risk-stratified pathways (RSPs) are recommended by the European Association of Uro-logy (EAU) to improve early detection clinically significant prostate cancer (csPCa). RSPs can reduce magnetic resonance imaging (MRI) demand, biopsies, and over-detection insignificant PCa (iPCa). Our goal is analyze efficacy cost-effectiveness several using sequential stratifications from serum prostate-specific antigen level digital rectal examination, Barcelona risk calculators (BCN-RCs), MRI, Proclarix™....
Background Prostate cancer (PCa) is a leading cause of cancer-related deaths in European men, emphasizing the urgent need for effective risk assessment strategies. The TP53 gene, tumor suppressor gene frequently mutated cancer, commonly harbors rs1042522 single nucleotide polymorphism (SNP), known as P72R SNP, which may influence PCa susceptibility. This study investigated prevalence SNP Caucasian samples and its association with risk. Methods Genotyping was conducted on 12 hormone-naïve...
PURPOSE To analyze the association between prostatic proliferative inflammatory atrophy finding in negative prostate biopsies and future detection of cancer (PCa) its aggressiveness men subjected to repeat biopsies, due persistent suspicion PCa. MATERIALS AND METHODS Prospective observational study 474 scheduled repeated PBs. Assessment PIA extension previous biopsy. PCa rate tumor aggressiveness. Age, serum total PSA, free percent PSA (%fPSA), digital rectal exam (DRE), volume (PV), density...