A5046457930- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Diabetes Management and Research
- Cardiac electrophysiology and arrhythmias
- Tissue Engineering and Regenerative Medicine
- Sepsis Diagnosis and Treatment
- Cardiac pacing and defibrillation studies
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Thyroid Disorders and Treatments
- Cardiac Arrest and Resuscitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Structural Anomalies and Repair
- Hemoglobinopathies and Related Disorders
- Pregnancy-related medical research
- Neuroendocrine Tumor Research Advances
- Cardiac Ischemia and Reperfusion
- Iron Metabolism and Disorders
- Nitric Oxide and Endothelin Effects
- Mechanical Circulatory Support Devices
- Cardiovascular Effects of Exercise
- Erythropoietin and Anemia Treatment
Universidade do Porto
2015-2025
Hospital de São João
2014-2025
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2017-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Faculdade de Medicina do ABC
2022-2023
Institut Cochin
2022
Cleveland Clinic Lerner College of Medicine
2022
Maastricht University
2018
The NAD + precursor nicotinamide improves diastolic dysfunction caused by aging, hypertension, or metabolic syndrome in rodents.
To perform a post hoc analysis of the FIGHT trial, evaluating effect liraglutide (vs. placebo) on totality events in patients with heart failure reduced ejection fraction (HFrEF).FIGHT was double-blind randomized controlled trial (RCT) that studied versus placebo 300 recently hospitalized HFrEF followed for 180 days. The main outcome present total hospitalizations (HF) or all-cause death. Secondary outcomes included arrhythmic and prespecified interest (arrhythmias, sudden cardiac death,...
OBJECTIVE Patients with type 2 diabetes (T2D) have a high risk for developing heart failure (HF), which is associated poor prognosis. Fenofibrate may reduce HF events through multiple mechanisms. We sought to study the effect of fenofibrate (vs. placebo) in outcomes among patients T2D receiving simvastatin enrolled Action Control Cardiovascular Risk Diabetes lipid trial (ACCORD Lipid). RESEARCH DESIGN AND METHODS used Cox regression analysis background glucose-lowering strategy as...
Acute heart failure (AHF) is one of the main causes unplanned hospitalization in patients >65 years age and associated with adverse outcomes this population. Observational studies suggest that intravenous diuretic therapy given first hour presentation for AHF was favorable outcomes.To study short-term prognostic associations timing admitted to emergency department (ED) acute AHF.Patients treated ED diuretics were selected from Estratificação de Doentes com InsuFIciência Cardíaca Aguda...
So far, opposing outcomes have been reported following neonatal apex resection in mice, questioning the validity of this injury model to investigate regenerative mechanisms. We performed a systematic evaluation, up 180 days after surgery, pathophysiological events activated upon resection. In response cardiac injury, we observed increased cardiomyocyte proliferation remote and regions, neovascularization, local fibrosis. adulthood, resected hearts remain consistently shorter display...
Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on myocardium remain unclear. The aim study was to compare angiotensin and norepinephrine cardiac function myocardial oxygen consumption, inflammation injury experimental shock.This randomized, open-label, controlled performed 20 anesthetized mechanically ventilated pigs. Septic shock induced by fecal peritonitis 16 animals, four pigs served as shams. Resuscitation with fluids, antimicrobial...
Extubation during extracorporeal oxygenation (ECMO) in severe acute respiratory distress syndrome (ARDS) has not been well studied. Despite the potential benefits of this strategy, weaning from ECMO before liberation invasive mechanical ventilation remains most frequent approach. Our aim was to evaluate safety and feasibility a standardized approach for extubation patients with ARDS.We conducted prospective observational study assess ARDS among 254 adult across 4 intensive care units (ICU) 2...
Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated IPF, the genetic factors contributing HP (fHP) remain poorly understood. This study investigated association of
Septic cardiomyopathy is an increasingly relevant topic in clinical management of septic shock. However, pathophysiological mechanisms and long-term consequences sepsis-induced myocardial injury are still poorly understood. Herein, new histological evidence provided suggesting association edema formation with tissue subsequent remodeling shock patients. This preliminary data supports as a potentially largely unexplored mechanism human cardiomyopathy.
Heart-on-chip is an unprecedented technology for recapitulating key biochemical and biophysical cues in cardiac pathophysiology. Several designs have been proposed to improve its ability mimic the native tissue establish it as a reliable research platform. However, despite mimicking one of most vascularized organs, strategies deliver oxygen substrates densely packed constructs metabolically demanding cells remain unsettled. Herein, we describe new heart-on-chip platform with precise fluid...