A5063029632- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Disease and Adiposity
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Electrolyte and hormonal disorders
- Apelin-related biomedical research
- Diet and metabolism studies
- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Eosinophilic Esophagitis
- Nitric Oxide and Endothelin Effects
- Sepsis Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Heart Failure Treatment and Management
- IL-33, ST2, and ILC Pathways
- Aortic Disease and Treatment Approaches
Université Libre de Bruxelles
2019-2024
Angiotensin II is one of the vasopressors available for use in septic shock. However, its effects on myocardium remain unclear. The aim study was to compare angiotensin and norepinephrine cardiac function myocardial oxygen consumption, inflammation injury experimental shock.This randomized, open-label, controlled performed 20 anesthetized mechanically ventilated pigs. Septic shock induced by fecal peritonitis 16 animals, four pigs served as shams. Resuscitation with fluids, antimicrobial...
Pulmonary hypertension and right ventricular (RV) dysfunction are major prognostic determinants in patients with heart failure preserved ejection fraction (HFpEF). The underlying pathomechanisms remain unknown. In this context, we sought to study the pathogenesis of pulmonary RV a rat model obesity-associated HFpEF.
Heart failure with preserved ejection fraction (HFpEF) is a common complex clinical syndrome for which there are currently few evidence-based therapies. As patients HFpEF very often present comorbidities comprising the metabolic syndrome, we hypothesized, that could lead over time to development of diastolic dysfunction and HFpEF. Obesity-prone rats were exposed high-fat diet compared obesity-resistant fed standard chow. Phenotyping associated echocardiographic cardiac hemodynamic...
Background: While chemerin has been shown to increase proliferation and migration of systemic vascular smooth muscle cells (SMCs) contributing therefore the development hypertension, this remains be clarified for pulmonary circulation. Methods: Expression its three receptors (CMKRL1, CCRL2, GPR1) was examined by immunohistochemistry RTq-PCR in lungs, artery thoracic aorta from Wistar rats. Primary cultured rat SMCs treated with recombinant (tested 5.10-9 10-7 mol/L) were assessed (both mol/L...
To explore the impact of omecamtiv mecarbil (OM) on gene expression profile in adult male rats. Fourteen Wistar rats were randomly assigned to a single OM (1.2 mg/kg/h; n = 6) or placebo (n 8) 30-min infusion. Echocardiography was performed before and after Seven days infusion, euthanized, left ventricular (LV) tissues removed for real-time quantitative polymerase chain reaction (RTq-PCR) experiments. After pro-apoptotic Bax-to-Bcl2 ratio decreased, with increased Bcl2 similar Bax...
In patients with chronic aortic regurgitation (AR), excessive preload and afterload increase left ventricle wall stress, leading to ventricular systolic dysfunction. Thus, the objective of present study was evaluate effects myosin activator omecamtiv mecarbil (OM) on stress in an experimental rat model severe AR. Forty adult male Wistar rats were randomized into two groups: induction AR (acute phase) by retrograde puncture (n = 34) or a sham intervention 6). Rats that survived acute phase...
Both N-terminal fragment of B-type natriuretic peptide (NT-proBNP) and soluble isoform ST2 (sST2) have been identified as biomarkers heart failure. We evaluated the plasma levels NT-proBNP sST2 in a rat model severe aortic valve regurgitation (AR) correlated these findings with echocardiographic measurements. also examined impact omecamtiv mecarbil (OM) on parameters.The were measured 18 rats both before 2 months after surgical induction AR, at same time points, six assigned to...