A5042123921- Liver physiology and pathology
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Tissue Engineering and Regenerative Medicine
- dental development and anomalies
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Renal and Vascular Pathologies
- DNA Repair Mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Muscle Physiology and Disorders
- Bone and Dental Protein Studies
- BRCA gene mutations in cancer
- Renal and related cancers
- Medical and Biological Ozone Research
- Fibroblast Growth Factor Research
- Diabetes and associated disorders
- Congenital heart defects research
- Genetic factors in colorectal cancer
- Metabolism, Diabetes, and Cancer
- Augmented Reality Applications
- Academic Research in Diverse Fields
Universidade do Estado do Rio de Janeiro
2014-2025
Cultura
2006-2013
Aim The aim of the present study was to evaluate whether activation peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma by Bezafibrate (BZ) could attenuate hepatic white adipose tissue (WAT) abnormalities in male offspring from diet-induced obese dams. Materials Methods C57BL/6 female mice were fed a standard chow (SC; 10% lipids) diet or high-fat (HF; 49% for 8 weeks before mating during gestation lactation periods. Male received SC at weaning subdivided into four groups:...
Leishmania amazonensis activates the NF-κB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated role of PI3K/Akt in p50/p50 activation effect on iNOS expression L. infection. The increased occupancy promoter infected macrophages was observed we demonstrated that both induction downregulation depended activation. Importantly, intracellular growth parasite also impaired during signalling inhibition knocked-down for Akt 1...
Liver fibrosis results from chronic injury followed by activation of macrophages and fibrogenic cells like myofibroblasts activated hepatic stellate cells. These express α-smooth muscle actin (α-SMA) produce excessive extracellular matrix (ECM), with disorganization loss function parenchyma. It is known that increased levels metalloproteinases (MMPs) in liver are associated reduction the pathologic ECM resolution. Recently, it has been shown bone marrow mononuclear (BMMNCs) may reduce...
Progressive renal fibrosis is an underlying pathological process of chronic kidney disease (CKD) evolution. This study aimed to evaluate the roles bone-marrow-derived mesenchymal stem cells (MSC) in remodeling fibrotic parenchyma two kidneys-one clip (2K1C) CKD animal model.Wistar rats were allocated into three groups: Sham, 2K1C, and 2K1C þ MSC. MSCs (106) transplanted subcapsular region weeks after clipping left artery. Six clipping, samples analyzed using histological western blotting...
Liver fibrosis is accompanied by hepatocyte death and proliferation of α-SMA(+) fibrogenic cells (activated hepatic stellate myofibroblasts), which synthesize extracellular matrix components that contribute to disorganization the parenchyma loss liver function. Therefore, apoptosis these important regeneration. This study aimed analyze effect cell therapy using bone marrow mononuclear (BMMNC) transplantation on α-SMA expression during induced bile duct ligation (BDL). Livers were collected...
Introduction: Maternal obesity has been positively correlated with an increased cardiometabolic risk in the offspring throughout life, implying intergenerational transmission. However, little is known about early life cardiac cell modifications that imply onset of heart diseases later life. This study analyzed progenitor cells and cardiomyocyte differentiation on day birth born to obese dams. Methods: The litter size reduction model was used induce female Swiss mice. Both maternal groups,...
ExoU is an important virulence factor in acute Pseudomonas aeruginosa infections. Here, we unveiled the mechanisms of ExoU-driven NF-κB activation by using human airway cells and mice infected with P. strains. Several approaches showed that PAFR was crucially implicated canonical pathway. Confocal microscopy lungs from revealed PAFR-dependent occurred mainly respiratory epithelial cells, reduced p65 nuclear translocation detected PAFR-/- or treated antagonist WEB 2086. evidences ExoU-induced...
Bone marrow cells (BMC) migrate to the injured liver after transplantation, contributing regeneration through multiple pathways, but mechanisms involved are unclear. This work aimed study BMC migration, characterize cytokine profile, cell populations and proliferation in mice with fibrosis transplanted GFP+ BMC. Confocal microscopy analysis showed near regions expressing HGF SDF-1 fibrotic liver. Impaired groups was restored transplantation. Regarding total populations, there a significant...
Abstract The adult bone marrow retains two populations of stem cells with emerging importance for the treatment diverse liver diseases: hematopoietic (HSCs) and mesenchymal (MSCs). However, mechanisms that control regeneration after cell transplantation are still controversial. Liver partial hepatectomy is a complex process requires proliferation all hepatic cells. Growth factors, cytokines extracellular matrix molecules key elements in this process. Laminins family proteins adhesive...
To analyze therapeutic potential of the conditioned medium from adipose tissue-derived stem cells (ASC) cultivated in 2D (CM-2D) and 3D (CM-3D) models, mice with Type 1 diabetes (T1D) induced by streptozotocin.Viability andCD105 expression ASC were analyzed flow cytometry. T1D was multiple injections streptozocin. On 28th 29th days after first injection streptozocin, diabetic animals received CM-2D or CM-3D. Pancreatic, CM-2D, CM-3D cytokines cytometric bead array (CBA) insulin PDX-1...
The ultimate goal of periodontal therapy is to repair the damaged supporting tissues, permitting regeneration ligament.However, cell response, supportive matrix and bioactive molecules use have not yet been well established.Bone marrow mononuclear cells were extracted from rat femurs tibiae cultured on a cross-linked collagen membrane, bone graft, or molar tooth compare attachment early proliferation these materials.Cell was quantified by light microscopy at 24, 48 72h, observed under SEM...