A5033011683- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- NMR spectroscopy and applications
- Neonatal and fetal brain pathology
- Solid-state spectroscopy and crystallography
- Prostate Cancer Diagnosis and Treatment
- Enzyme Structure and Function
- Lanthanide and Transition Metal Complexes
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Fetal and Pediatric Neurological Disorders
- Prostate Cancer Treatment and Research
- Fibroblast Growth Factor Research
- Phagocytosis and Immune Regulation
- Glioma Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Boron Compounds in Chemistry
- Cardiac Imaging and Diagnostics
- Amino Acid Enzymes and Metabolism
- Liver Disease Diagnosis and Treatment
University of California, San Francisco
2016-2025
University of California System
2016-2025
Neurological Surgery
1994-2025
University of California, Berkeley
2016-2025
Institute for Bioengineering of Catalonia
2023
University of California, San Diego
2021
Berry (United States)
2021
Laboratoire d’Imagerie Biomédicale
2011-2020
Graduate Theological Union
2007-2017
San Francisco VA Medical Center
1986-2017
Metabolic imaging with hyperpolarized pyruvate was used to safely and noninvasively visualize prostate tumors in patients.
Congenital heart disease in newborns is associated with global impairment development. We characterized brain metabolism and microstructure, as measures of maturation, congenital before they underwent surgery.We studied 41 term disease--29 who had transposition the great arteries 12 single-ventricle physiology--with use magnetic resonance imaging (MRI), spectroscopy (MRS), diffusion tensor (DTI) cardiac surgery. calculated ratio N-acetylaspartate to choline (which increases maturation),...
A major challenge in cancer biology is to monitor and understand metabolism vivo with the goal of improved diagnosis perhaps therapy. Because complexity biochemical pathways, tracer methods are required for detecting specific enzyme-catalyzed reactions. Stable isotopes such as (13)C or (15)N detection by nuclear magnetic resonance provide necessary information about tissue biochemistry, but crucial metabolites present low concentration therefore beyond threshold traditional methods. solution...
PURPOSE: To evaluate if three-dimensional hydrogen-1 magnetic resonance spectroscopic imaging (3D MRSI) when combined with a clinical MR examination could discriminate prostatic adenocarcinoma from normal zonal anatomy and benign hyperplasia (BPH) on the basis of observable metabolite levels. MATERIALS AND METHODS: Combined phased-array, endorectal 3D MRSI was performed in nine young healthy volunteers, five patients BPH, 85 prostate cancer BPH. Volume data were analytically corrected for...
PURPOSE: To assess the efficacy of combined magnetic resonance (MR) imaging and three-dimensional (3D) proton MR spectroscopic in detection localization prostate cancer. MATERIALS AND METHODS: 3D examinations were performed 53 patients with biopsy-proved cancer subsequent radical prostatectomy step-section histopathologic examination. The was divided into sextants. At imaging, presence or absence peripheral zone each sextant assessed independently by two readers (readers 1 2) unaware...
An extraordinary new technique using hyperpolarized (13)C-labeled pyruvate and taking advantage of increased glycolysis in cancer has the potential to improve way magnetic resonance imaging is used for detection characterization prostate cancer. The aim this study was quantify, first time, differences [1-(13)C] its metabolic products between various histologic grades transgenic adenocarcinoma mouse (TRAMP) model. Fast spectroscopic techniques were image lactate, alanine, total carbon (THC =...
Purpose A calibrationless parallel imaging reconstruction method, termed simultaneous autocalibrating and k-space estimation (SAKE), is presented. It a data-driven, coil-by-coil method that does not require separate calibration step for estimating coil sensitivity information. Methods In SAKE, an undersampled, multichannel dataset structured into single data matrix. The then formulated as low-rank matrix completion problem. An iterative solution implements projection-onto-sets algorithm with...
Abstract Diffusion tensor imaging (DTI) accurately delineates white matter pathways when the Gaussian model of diffusion is valid. However, DTI yields erroneous results takes on a more complex distribution, as case in brain fiber tracts cross. High angular resolution (HARDI) overcomes this limitation by fully characterizing dependence intravoxel diffusion. Among various HARDI methods that have been proposed, QBI offers advantages such linearity, independence, and relatively easy...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Aug 2000SEXTANT LOCALIZATION OF PROSTATE CANCER: COMPARISON SEXTANT BIOPSY, MAGNETIC RESONANCE IMAGING AND SPECTROSCOPIC WITH STEP SECTION HISTOLOGY A.E. WEFER, H. HRICAK, D.B. VIGNERON, F.V. COAKLEY, Y. LU, J. U. MUELLER-LISSE, P.R. CARROLL, and KURHANEWICZ WEFERA.E. WEFER , HRICAKH. HRICAK VIGNEROND.B. VIGNERON COAKLEYF.V. COAKLEY LUY. LU WEFERJ. MUELLER-LISSEU. MUELLER-LISSE CARROLLP.R. CARROLL KURHANEWICZJ. View All Author...
<b><i>Background:</i></b> There is controversy over whether seizures, the most common manifestation of neonatal brain injury, may themselves damage developing brain. <b><i>Objective:</i></b> To determine if seizures are independently associated with injury in newborns perinatal asphyxia. <b><i>Methods:</i></b> Ninety term neonates were studied MRI and single-voxel <sup>1</sup>H-MRS on median day life 6 (range 1 to 13 days). The severity MR abnormality regions interest was scored using a...
PURPOSE: To determine if the addition of three-dimensional (3D) proton magnetic resonance (MR) spectroscopic imaging to endorectal MR helps diagnose extracapsular extension (ECE) prostate cancer. MATERIALS AND METHODS: Endorectal and 3D were performed in 53 patients with cancer before radical prostatectomy. studies evaluated by two independent readers unaware histopathologic findings. The presence ECE was graded on a five-point scale. At imaging, diagnosed ratio choline plus creatine citrate...
Abstract Purpose To determine the change over time of apparent diffusion coefficient (ADC) and relative anisotropy cerebral water in a cohort premature newborns serially studied near birth again term. Materials Methods Newborns were classified as normal ( N = 11), minimal white matter injury 7), or moderate 5). Results ADC decreased significantly with age all brain regions those injury. increased failed to decline widespread areas Anisotropy normal. did not increase frontal injury,...
To compare the performance of pelvic phased-array (PPA) coils and integrated endorectal PPA in evaluation local extent prostate cancer.Seventy-one men underwent magnetic resonance (MR) imaging within 3 weeks radical prostatectomy. MR findings tumor, extracapsular extension, seminal vesicle invasion, nodal involvement, stage were compared with step-sectioned (3-4-mm intervals) whole-mounted pathologic specimens. Prospective consensus versus single-reader interpretation (kappa statistics)...
To assess the frequency of changes in signal intensity after prostatic biopsy and effect these on magnetic resonance (MR) imaging staging prostate cancer.Seventy-three patients with biopsy-proved cancer were divided into two groups according to time between (less than more 21 days). The findings at MR compared those pathologic examination.Postbiopsy hemorrhage was detected 26 (81%) who underwent less days 23 47 (49%) (P < .01). Postbiopsy persisted for as long 4 1/2 months. Less biopsy,...