A5051168746- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- NMR spectroscopy and applications
- Molecular spectroscopy and chirality
- Spectroscopy and Chemometric Analyses
- Atomic and Subatomic Physics Research
- Photosynthetic Processes and Mechanisms
- Protein Structure and Dynamics
- Prostate Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
- Toxic Organic Pollutants Impact
- Plant nutrient uptake and metabolism
- Cellular transport and secretion
- Neurological disorders and treatments
- Lanthanide and Transition Metal Complexes
- Metabolomics and Mass Spectrometry Studies
- Parkinson's Disease Mechanisms and Treatments
- Connexins and lens biology
- Metabolism and Genetic Disorders
- Neural Networks and Applications
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Advanced Proteomics Techniques and Applications
Laboratoire d’Imagerie Biomédicale
2014-2016
Bioengineering Center
2016
University of California, San Francisco
1996-2015
University of California System
2015
Aix-Marseille Université
2013
Inserm
2013
University Hospital Complex Of Vigo
2013
University Hospital Cologne
2013
Fujita Health University Hospital
2013
Sorbonne Université
2013
PURPOSE: To assess the efficacy of combined magnetic resonance (MR) imaging and three-dimensional (3D) proton MR spectroscopic in detection localization prostate cancer. MATERIALS AND METHODS: 3D examinations were performed 53 patients with biopsy-proved cancer subsequent radical prostatectomy step-section histopathologic examination. The was divided into sextants. At imaging, presence or absence peripheral zone each sextant assessed independently by two readers (readers 1 2) unaware...
PURPOSE: To determine if the addition of three-dimensional (3D) proton magnetic resonance (MR) spectroscopic imaging to endorectal MR helps diagnose extracapsular extension (ECE) prostate cancer. MATERIALS AND METHODS: Endorectal and 3D were performed in 53 patients with cancer before radical prostatectomy. studies evaluated by two independent readers unaware histopathologic findings. The presence ECE was graded on a five-point scale. At imaging, diagnosed ratio choline plus creatine citrate...
We present for the first time dynamic spectra and spectroscopic images acquired in normal rats at 3T following injection of (13)C-1-pyruvate that was hyperpolarized by nuclear polarization (DNP) method. Spectroscopic sampling optimized signal-to-noise ratio (SNR) spectral resolution its metabolic products (13)C-1-alanine, (13)C-1-lactate, (13)C-bicarbonate. Dynamic were collected with a temporal 3 s from 90-mm axial slab using dual (1)H-(13)C quadrature birdcage coil to observe combined...
Abstract One of the challenges optimizing signal‐to‐noise ratio (SNR) and image quality in 13 C metabolic imaging using hyperpolarized C‐pyruvate is associated with different MR signal time‐courses for pyruvate its products, lactate alanine. The impact acquisition time window, variation flip angles, order phase encoding on SNR were evaluated mathematical simulations rat experiments, based multishot fast chemical shift (CSI) three‐dimensional echo‐planar spectroscopic (3DEPSI) sequences....
Patients with primary brain tumors may be considered for several different treatments during the course of their disease. Assessments disease progression and response to therapy are typically performed by visual interpretation serial MRI examinations. Although such examinations provide useful morphologic information, they unable reliably distinguish active tumor from radiation necrosis. This poses a particular problem in assessment localized therapies as gamma knife radiosurgery. In this...
PURPOSE: Image-guided, single-voxel, localized proton magnetic resonance (MR) spectroscopy was performed to assess white matter in childhood adrenoleukodystrophy (ALD). MATERIALS AND METHODS: Eleven X-linked ALD subjects, seven with neurologic symptoms or lesions at MR imaging and four asymptomatic patients, were compared nine aged-matched, healthy volunteers. RESULTS: Compared those from normal matter, spectra (n = 6) showed 65% reduction the ratio of N-acetyl aspartate (NAA) total creatine...
<h3>BACKGROUND AND PURPOSE:</h3> In vivo MR imaging and postmortem neuropathologic studies have demonstrated elevated iron concentration atrophy within the striatum of patients with Huntington disease, implicating neuronal loss accumulation in pathogenesis this neurodegenerative disorder. We used 7T to determine whether quantitative phase, a measurement that reflects both content tissue microstructure, is altered subjects premanifest disease. <h3>MATERIALS METHODS:</h3> Local field shift,...
Although histopathological diagnosis is essential in decision of therapeutic strategy for gliomas, sometimes the tumors diagnosed one histological entity show thoroughly different clinical courses.This phenomenon believed to be due primarily presence genetic subgroup.In fact, relationship between treatment response and certain characteristics indicated (e.g.better chemosensitivity glioma with losses 1p/19q (21p/19q)).It highly likely that classification useful select adjuvant...
Accurate diagnosis is critical for the treatment planning of brain tumors. At present, classification tumor based on histological examination tissue samples. This invasive and may be subject to sampling errors. Magnetic resonance spectroscopic imaging (MRSI) a non-invasive technique that provides functional information has been proposed as tool grading. The goal this work find method (1) explicitly combines from MRSI MR (MRI); (2) considers characteristics entire lesion instead pre-selected...
Diffuse intrinsic pontine gliomas (DIPGs) continue to have a very poor prognosis with median survival rate of 9 months. The methods for assessing treatment response and tumor progression are based on radiographic but conventional MRI is not sufficient predicting clinical outcome. A recent first-in-human study using hyperpolarized 13C MR metabolic imaging showed the safety feasibility this technology evaluating pyruvate metabolism in humans. purpose was demonstrate [1-13C]pyruvate as...
This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed cervical cords naive rats. Lactate measures similar for supratentorial brain. The results from this establish baseline MRS 13C pyruvate. technique holds promise as a valuable molecular tool monitoring biochemical processes normal diseased cord.