A5033201306- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- MRI in cancer diagnosis
- Solid-state spectroscopy and crystallography
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced Radiotherapy Techniques
- NMR spectroscopy and applications
- Medical Imaging and Analysis
- Advanced Neuroimaging Techniques and Applications
- Medical Image Segmentation Techniques
- Advanced Neural Network Applications
- Fetal and Pediatric Neurological Disorders
- Amino Acid Enzymes and Metabolism
- Meta-analysis and systematic reviews
- Medical Imaging and Pathology Studies
- Biosimilars and Bioanalytical Methods
- Boron Compounds in Chemistry
- Spectroscopy Techniques in Biomedical and Chemical Research
- Lanthanide and Transition Metal Complexes
- Soft Robotics and Applications
- Spectroscopy and Chemometric Analyses
Advanced Imaging Research (United States)
2020-2021
The University of Texas Southwestern Medical Center
2020-2021
Baylor Scott & White Health
2018-2021
General Electric (Spain)
2018-2021
General Electric (United States)
2021
HeartVista (United States)
2015-2020
General Electric (Canada)
2019
University of California, San Francisco
2009-2016
University of California, Berkeley
2014-2016
Graduate Theological Union
2010-2014
Metabolic imaging with hyperpolarized pyruvate was used to safely and noninvasively visualize prostate tumors in patients.
Abstract Magnetic resonance imaging is an inherently signal-to-noise-starved technique that limits the spatial resolution, diagnostic image quality and results in typically long acquisition times are prone to motion artefacts. This limitation exacerbated when receive coils have poor fit due lack of flexibility or need for padding patient comfort. Here, we report a new approach uses printing fabricating coils. Our enables highly flexible, extremely lightweight conforming devices. We show...
<sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> C steady state free precession (SSFP) magnetic resonance imaging and effective spin-spin relaxation time (T2) mapping were performed using hyperpolarized [ C] urea C, xmlns:xlink="http://www.w3.org/1999/xlink">15</sup> N <sub xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ] injected intravenously in rats. labeling gave large T2 increases both solution vivo due to the elimination of a...
Abstract Metabolic reprogramming is one of the defining features cancer and abnormal metabolism associated with many other pathologies. Molecular imaging techniques capable detecting such changes have become essential for diagnosis, treatment planning, surveillance. In particular, 18 F-FDG (fluorodeoxyglucose) PET has emerged as an modality because its unique ability to detect a disturbed molecular pathway through measurements glucose uptake. However, FDG-PET limitations that restrict...
Purpose To demonstrate simultaneous hyperpolarization and imaging of three 13 C‐labeled perfusion MRI contrast agents with dissimilar molecular structures ([ C]urea, [ C]hydroxymethyl cyclopropane, C]t‐butanol) correspondingly variable chemical shifts physiological characteristics, to exploit their varying diffusibility for measurement vascular permeability in initial preclinical studies. Methods Rapid efficient dynamic multislice was enabled by a novel pulse sequence incorporating balanced...
Purpose The combined hyperpolarized (HP) 13 C pyruvate and urea MRI has provided a simultaneous assessment of glycolytic metabolism tissue perfusion for improved cancer diagnosis therapeutic evaluation in preclinical studies. This work aims to translate this dual‐probe HP imaging technique clinical research. Methods A co‐polarization system was developed where [1‐ C]pyruvic acid (PA) [ C, 15 N 2 ]urea water solution were homogeneously mixed polarized on 5T SPINlab system. Physical chemical...
Abstract Purpose: To determine the best combination of magnetic resonance imaging (MRI) parameters for detection locally recurrent prostate cancer after external beam radiation therapy. Materials and Methods: Our Institutional Review Board approved this study with a waiver informed consent. Twenty‐six patients suspected recurrence due to biochemical failure were part research. The MR protocol included T2‐weighted, spectroscopy, diffusion‐weighted MRI. Transrectal ultrasound‐guided biopsy was...
Purpose Acquisition timing and B 1 calibration are two key factors that affect the quality accuracy of hyperpolarized 13 C MRI. The goal this project was to develop a new approach using regional bolus tracking trigger Bloch‐Siegert mapping real‐time based on measurements, followed by dynamic imaging metabolites in vivo. Methods proposed implemented system which allows data processing control sequence. Real‐time center frequency upon arrival also added. feasibility applying framework for vivo...
Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these non-invasively vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we demonstrate that tumor xenografts with similar genetic background distinguished by their differing rates of the metabolism 13C labeled glucose tracers, which imaged without hyperpolarization using newly developed techniques noise suppression. this method, subtypes...
In vivo spin relaxation time (T2) heterogeneity of hyperpolarized [13C,15N2]urea in the rat kidney was investigated. Selective quenching vascular 13C signal with a macromolecular agent revealed that long-T2 component originated from renal extravascular space, thus allowing and filtrate contrast pools to be distinguished via multi-exponential analysis. The T2 response induced diuresis antidiuresis performed two imaging agents: control bis-1,1-(hydroxymethyl)-1-13C-cyclopropane-2H8. Large...
With the initiation of human hyperpolarized 13 C (HP-13 C) trials at multiple sites and development improved acquisition methods, there is an imminent need to maximally extract diagnostic information facilitate clinical interpretation. This study aims improve HP-13 MR spectroscopic imaging through means Tensor Rank truncation-Image enhancement (TRI) optimal receiver combination (ORC).A data-driven processing framework for dynamic HP (MRSI) was developed. Using patient data sets acquired with...
The purpose of this study was to investigate the MRI and MR spectroscopy features mucinous adenocarcinoma prostate.MRI do not appear provide ability reliably detect lakes extracellular mucin seen in prostate.
Purpose Hyperpolarized 13 C magnetic resonance allows for the study of real‐time metabolism in vivo, including significant hyperpolarized lactate production many tumors. Other studies have shown that aggressive and highly metastatic tumors rapidly transport out cells. Thus, ability to not only measure but also understand its compartmentalization using diffusion‐weighted MR will provide unique information improved tumor characterization. Methods We used a bipolar, pulsed‐gradient, double spin...
Purpose To investigate hyperpolarized 13 C metabolic imaging methods in the primate brain that can be translated into future clinical trials for patients with cancer. Methods coils and pulse sequences designed use humans were tested phantoms. Dynamic data obtained from a healthy cynomolgus monkey using optimized sequences. The metabolite kinetics estimated two‐dimensional localized dynamic nonhuman brain. Results Pyruvate lactate signal observed both surrounding tissues maximum...
Balanced steady-state free precession (bSSFP) sequences can provide superior signal-to-noise ratio efficiency for hyperpolarized (HP) carbon-13 (13 C) magnetic resonance imaging by efficiently utilizing the nonrecoverable magnetization, but managing their spectral response is challenging in context of metabolic imaging. A new spectrally selective bSSFP sequence was developed fast multiple HP 13 C metabolites with high spatiotemporal resolution.This novel approach selectivity incorporates...
To translate any robot into a clinical environment, it is critical that the can seamlessly integrate with all technology of modern clinic. MRBot, an MR-stealth brachytherapy delivery device, was used in closed-bore 3T MRI and cone beam CT suite. Targets included ceramic dummy seeds, MR-Spectroscopy-sensitive metabolite, prostate phantom. Acquired DICOM images were exported to planning software register coordinates imager's frame, contour verify target locations, create dose plans, export...
Purpose The purpose of this study was to directly compare two isotopic metabolic imaging approaches, hyperpolarized (HP) 13 C MRI and deuterium (DMI), for specific closely related segments cerebral glucose metabolism at 4.7 T. Methods Comparative HP‐ DMI neuroimaging experiments were conducted consecutively in normal rats during the same scanning session. Localized conversions [1‐ C]pyruvate [6,6‐ 2 H ]glucose their respective downstream products measured by spectroscopic imaging, using an...
Traumatic brain injury (TBI) involves complex secondary processes following the primary injury. The is often associated with rapid metabolic shifts and impaired function immediately after initial tissue damage. Magnetic resonance spectroscopic imaging (MRSI) coupled hyperpolarization of 13C-labeled substrates provides a unique opportunity to map changes in traumatic real-time without invasive procedures. In this report, we investigated two patients acute mild TBI (Glasgow coma scale 15) but...
Purpose Noninvasive imaging with hyperpolarized (HP) pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization parameters, understanding MR characteristics such as s HP signals is critical. This study to measure [1‐ 13 C]pyruvate products rodents humans. Methods A dynamic C multi‐echo spiral sequence that acquires [ C]bicarbonate, C]lactate, images an interleaved manner was implemented for a clinical 3 Tesla system. each metabolite...