A5069066377- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Urinary Tract Infections Management
- Patient Satisfaction in Healthcare
- Antimicrobial Resistance in Staphylococcus
- Long-Term Effects of COVID-19
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- COVID-19 Impact on Reproduction
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Fungal Infections and Studies
- Neutropenia and Cancer Infections
- Complementary and Alternative Medicine Studies
- Prion Diseases and Protein Misfolding
- Drug-Induced Adverse Reactions
- Healthcare cost, quality, practices
- COVID-19 and Mental Health
- Infective Endocarditis Diagnosis and Management
- Rabies epidemiology and control
- Healthcare Policy and Management
- Streptococcal Infections and Treatments
- Microscopic Colitis
Unity Health System
2017-2024
Rochester General Hospital
2014-2023
University of Rochester
2021
University of Rochester Medical Center
2016
Office of Infectious Diseases
2014
Background. Most inactivated influenza vaccines contain purified and standardized hemagglutinin (HA) residual neuraminidase (NA) antigens. Vaccine-associated HA antibody responses (hemagglutination inhibition [HAI]) are well described, but less is known about the immune response to NA. Methods. Serum of 1349 healthcare personnel (HCP) electing or declining 2010-2011 trivalent-inactivated vaccine ([IIV3], containing A/California/7/2009 p(H1N1), A/Perth/16/2009 [H3N2], B/Brisbane/60/2008...
The implementation of a penicillin allergy screening tool to optimize the use aztreonam is described.This study was conducted at 528-bed tertiary referral community teaching facility and compared in patients before after multipronged intervention consisting (PAST), education, order set decision support, prospective review orders by antimicrobial stewardship team clinical pharmacists. Patients for whom prescribed any time during their presentation hospital January 1-June 30, 2013...
Coronavirus disease 2019 (COVID-19) usually presents as a febrile illness with lower respiratory tract symptoms.1Wang D. Hu B. C. et al.Clinical characteristics of 138 hospitalized patients novel coronavirus-infected pneumonia in Wuhan, China.JAMA. 2020; 323: 1061-1069Crossref PubMed Scopus (16413) Google Scholar, 2Lui K. Fang Y. Deng coronavirus cases tertiary hospitals Hubei Province. Chin Med J (Engl).https://doi.org/10.1097/CM9.0000000000000744Google 3Chen N. Zhou M. Dong X....
Although rare, patients with variant Creutzfeldt-Jakob Disease (vCJD) in their differential diagnosis of progressive dementia and movement disorder could continue to present hospitals for care. However, U.S.-based infection control guidelines do not fully address the possibility vCJD. After near-misses involving increasing numbers clinical findings epidemiologic risks compatible vCJD, or exposures chronic wasting disease, we sought improve recognition prevention iatrogenic spread these...
Abstract Guillain‐Barre syndrome (GBS) is an acquired inflammatory polyradiculoneuropathy that often follows infection with a virus or bacteria and in rare occasions, vaccination may precede GBS. We present case of 80‐year‐old male patient who presented chief complaints progressive, ascending bilateral lower extremity paresthesia weakness following first dose Moderna vaccine. His symptoms got exacerbated after 2nd dose. Clinical examination investigation findings including lumbar puncture,...
To quantitatively evaluate relationships between infection preventionists (IPs) staffing levels, nursing hours, and rates of 10 types healthcare-associated infections (HAIs).An ambidirectional observation in a 528-bed teaching hospital.All inpatients from July 1, 2012, to February 2021.Standardized US National Health Safety Network (NHSN) definitions were used for HAIs. Staffing levels measured full-time equivalents (FTE) IPs total monthly hours worked nurses. A time-trend analysis using...
Abstract Background Convalescent plasma is being used widely as a treatment for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of COVID-19 convalescent unclear. Methods The Pass ive I mmunity T rial O ur N ation (PassITON) multicenter, placebo-controlled, blinded, randomized trial conducted in USA to provide high-quality evidence on adults hospitalized with symptomatic disease. Adults respiratory symptoms less than 14 days are eligible. Enrolled patients 1:1 ratio 1 unit...
Abstract Background: Fluoroquinolones (FQs) and extended-spectrum cephalosporins (ESCs) are associated with higher risk of Clostridioides difficile infection (CDI). Decreasing the unnecessary use FQs ESCs is a goal antimicrobial stewardship. Understanding how prescribers perceive risks benefits needed. Methods: We conducted interviews clinicians from 4 hospitals. Interviews elicited respondent perceptions about ESCs, FQs, CDI. were audio recorded, transcribed, analyzed using flexible coding...
Abstract Social media has emerged as a tool to facilitate communication and dissemination of information for both patients healthcare professionals. We describe 3 social engagement strategies used reach broad diverse audience on the topics infectious diseases antimicrobial stewardship, including use memes, clue-based knowledge assessment quiz, personality quiz. novel acronym “VIRAL” guide engaging in healthcare, eye catching Visuals, Interactive content, showing Respect empathy audience,...
Abstract Background Congestive heart failure has reached pandemic levels, and left-ventricular assist devices (LVAD) are increasingly used to treat refractory failure. Infection is a leading complication of LVADs. Despite numerous reports (most being retrospective), several knowledge gaps pertaining the epidemiology burden an LVAD-associated infection (LVADi) remain. We sought address these using prospective, case-control design. Methods All patients who received LVAD from November 1, 2018...
An antimicrobial stewardship intervention consisting of a urinary antibiogram and an electronic health record best-practice advisory promoted narrower-spectrum antibiotics for uncomplicated tract infections in hospitalized patients. Over 20 months, the significantly reduced ceftriaxone orders by 48% (P < .001) increased cefazolin use 19 times from baseline .001).
Mollaret's meningitis is an aseptic recurrent benign lymphocytic lasting 2-5 days and occurs over years with spontaneous complete resolution of symptoms between episodes. An 88 years-old-male presented acute onset headache, lethargy altered sensorium after a recent ear infection. He had multiple similar episodes in the past, each preceded by or sinus infection cerebrospinal fluid finding consistent meningitis. However, no specific causative agent was ever identified. confused, disoriented...
Background: Central venous catheter (CVC) utilization and central-line associated bloodstream infection (CLABSI) have increased nationwide. Busy providers can easily overlook the recommended practice of daily assessment ongoing indication for CVC. Prospective audit feedback (PAF) is widely used gold standard antibiotic stewardship programs (ASP), but reports involving PAF device use are scarce. Therefore, we decided to evaluate usefulness feasibility reducing ultimately CLABSI rates at our...
Abstract Engagement of frontline staff, along with senior leadership, in competition-style healthcare-associated infection reduction efforts, combined electronic clinical decision support tools, appeared to reduce antibiotic regimen initiations for urinary tract infections ( P = .01). Mean monthly standardized and device utilization ratios also decreased < .003 .0001, respectively).