Allison P. Wheeler
A5063509147- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Uterine Myomas and Treatments
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diversity and Career in Medicine
- SARS-CoV-2 detection and testing
- Blood transfusion and management
- Blood groups and transfusion
- Central Venous Catheters and Hemodialysis
- Reproductive Health and Contraception
- Blood properties and coagulation
- Renal Diseases and Glomerulopathies
- FinTech, Crowdfunding, Digital Finance
- Sex and Gender in Healthcare
- Neutropenia and Cancer Infections
- Respiratory viral infections research
- Hemoglobinopathies and Related Disorders
- Global Health Workforce Issues
Washington Center
2024-2025
University of Washington
2024-2025
Vanderbilt University Medical Center
1996-2024
Colorado Department of Public Health and Environment
2024
University of Colorado Anschutz Medical Campus
2024
Children's Hospital Colorado
2024
University of Colorado Denver
2024
Vanderbilt University
2016-2023
Monroe Carell Jr. Children's Hospital
2017-2023
Walker (United States)
2023
Cerebral venous sinus thrombosis (CVST) with thrombocytopenia, a rare and serious condition, has been described in Europe following receipt of the ChAdOx1 nCoV-19 vaccine (Oxford/AstraZeneca), which uses chimpanzee adenoviral vector. A mechanism similar to autoimmune heparin-induced thrombocytopenia (HIT) proposed. In US, Ad26.COV2.S COVID-19 (Janssen/Johnson & Johnson), human vector, received Emergency Use Authorization (EUA) on February 27, 2021. By April 12, 2021, approximately 7 million...
Moderate-to-severe hemophilia B is treated with lifelong, continuous coagulation factor IX replacement to prevent bleeding. Gene therapy for aims establish sustained activity, thereby protecting against bleeding without burdensome replacement.
Thrombosis with thrombocytopenia syndrome (TTS) is a potentially life-threatening condition associated adenoviral-vectored COVID-19 vaccination. It presents similarly to spontaneous heparin-induced thrombocytopenia. Twelve cases of cerebral venous sinus thrombosis after vaccination the Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) have previously been described.To describe surveillance data and reporting rates all reported TTS in United States.Case series.United patients receiving from 14...
As part of the response to highly pathogenic avian influenza A(H5N1) virus outbreak in U.S. cattle and poultry associated human cases, CDC partners are monitoring A levels detection H5 subtype wastewater. Among 48 states District Columbia that performed testing wastewater during May 12-July 13, 2024, a weekly average 309 sites 38 had sufficient data for analysis, 11 four reported high virus. was conducted at 203 41 states, with detections 24 nine states. For each or level, state local health...
Despite current therapies, there remains an unmet need for treatment patients with hemophilia. The main parts of two phase 2 trials established clinical proof-of-concept once-daily, subcutaneous concizumab prophylaxis in hemophilia A/B inhibitors (HAwI/HBwI; explorer4) and severe A without (HA; explorer5). Here, we present results from extension these trials, included to evaluate longer term safety efficacy. Both (≥24 weeks) (52-102 parts, receiving 0.15 mg/kg potential dose escalation 0.20...
Extended half-life (EHL) factor VIII (FVIII) and IX (FIX) products are intended to decrease the burden of prophylaxis for patients with haemophilia A or B. Whether these newer concentrates have led meaningful clinical practice change remains vague.To characterize longitudinal use standard (SHL) EHL at treatment centres (HTCs), using ATHNdataset, a US database 138 ATHN-affiliated HTCs.Factor concentrate among moderate severe B without inhibitors was analysed three time points over 18...
Surveillance for emerging pathogens is critical developing early warning systems to guide preparedness efforts future outbreaks of associated disease. To better define the epidemiology and burden respiratory disease acute flaccid myelitis (AFM), as well provide actionable data public health interventions, we developed a multimodal surveillance program in Colorado, USA, enterovirus D68 (EV-D68). Timely local, state, national outreach was possible because prospective syndromic AFM asthma-like...
ABSTRACT Disparities persist throughout medicine, including among conference speakership invitations. The National Institutes of Health have highlighted the importance diversity at academic conferences. We assessed gender composition speakers American Society for Apheresis (ASFA) annual meeting. all session chairs and ASFA meeting from 2019 to 2024. Two authors independently individuals' genders. primary outcome was by position. Subset analyzes were performed assess unique individuals (i.e.,...
ABSTRACT Immune thrombotic thrombocytopenic purpura (iTTP) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular occlusion secondary to acquired ADAMTS13 deficiency. Contemporary data regarding iTTP treatment practices in the US, including use of caplacizumab, are lacking. We aimed characterize demographics therapies, medications apheresis practices, patients with US. retrospectively analyzed cases at 15 sites US that provide comprehensive care for iTTP....
Introduction Turoctocog alfa pegol (N8‐GP) is a site‐specific, 40 kDa glycoPEGylated recombinant factor VIII (FVIII) product with an extended half‐life. The comprehensive main phase of the pivotal pathfinder 2 trial showed N8‐GP dosed every 4 days (Q4D) provided favourable safety and efficacy for preventing bleeds in 175 patients haemophilia A. Aim methods We investigated prophylaxis when administered weekly (Q7D) 24 weeks to low bleeding rates extension trial. Patients (≥12 years) ≤2 during...
Abstract Background and objectives Kaposiform hemangioendothelioma (KHE) tufted angioma (TA) are rare vascular tumors in children historically associated with significant morbidity mortality. This study was conducted to determine first‐line therapy the absence of available prospective clinical trials. Methods Patients from 17 institutions diagnosed KHE/TA between 2005 2020 more than 6 months follow‐up were included. Response rates sirolimus vincristine compared at 3 months. Durability...
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes diminished the ability to perform a rigorous assessment. This 5-year retrospective study assessed epidemiology of iTTP determined whether it displays pattern. Patients with both initial relapsed (defined as disintegrin metalloprotease thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada,...