A5100336152- Viral Infections and Vectors
- Gut microbiota and health
- Fire effects on ecosystems
- Clostridium difficile and Clostridium perfringens research
- Mosquito-borne diseases and control
- Gastrointestinal motility and disorders
- Viral Infections and Outbreaks Research
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Hydrology and Drought Analysis
- Zoonotic diseases and public health
- Neuroendocrine regulation and behavior
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Tryptophan and brain disorders
- Dietary Effects on Health
- Ginseng Biological Effects and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Sodium Intake and Health
- Virology and Viral Diseases
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
- interferon and immune responses
Yantaishan Hospital
2023-2024
Jiangxi Agricultural University
2023-2024
Gansu University of Traditional Chinese Medicine
2024
Institute of Geographic Sciences and Natural Resources Research
2024
Chinese Academy of Sciences
2024
Tianjin People's Hospital
2018-2023
University of Science and Technology of China
2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Animal Health Institute
2023
Berberine (BBR), an alkaloid isolated from
Butyrate, a key metabolite fermented by gut microbiota mainly from undigested carbohydrates such as dietary fibers is widely used feed additive. However, mechanisms of its contributions in maintaining host health are relatively poorly revealed. The aim this study was to investigate how butyrate impacts and immunity response high-fat diet-fed mice. Gut microbial analysis exhibited that intervention increased short-chain fatty acids (SCFAs)-producing bacteria decreased pathogenic bacteria,...
Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in human and animal. To determine the mechanism a bovine lactoferricin-lactoferrampin (LFCA)-encoding Lactobacillus reuteri CO21 (LR-LFCA) to enhance intestinal mucosal immunity, we used newborn piglet intestine model study response ETEC. Pigs were chosen due anatomical similarity between porcine intestine.4-day-old piglets orally administered with LR-LFCA, LR-con (L. transformed pPG612 plasmid) or phosphate buffered...
ObjectivesThe aim of this study was to dynamically investigate laboratory parameters and peripheral blood lymphocyte subsets in severe fever with thrombocytopenia syndrome (SFTS) patients at different stages, evaluate the significance these changes infection process its influence on prognosis.MethodsCase-control used research. Sixty-nine confirmed virus(SFTSV) infected were enrolled. They divided into two groups, recovery group poor prognosis group, according clinical diseases. The measured...
Fecal microbiota transplant (FMT) is a potential treatment approach for many diseases. Alzheimer's disease (AD) and cancer have been proven to specific antagonistic relationship FMT.This article aims explore whether intestinal flora transplantation from individuals can ameliorate cognitive impairment.Morris water maze object recognition tests were performed assess function after the fecal tumor-bearing WT mice transplanted into AD by gavage. The effect of on was analyzed thioflavin T...
Cancer is a disease with high mortality and disability rate. consists not only of cancer cells, but also the surrounding microenvironment tumor (TME) constantly interacting cells to support development progression. Over last decade, accumulating evidence has implicated that microbiota profoundly influences initiation Most research focuses on gut microbiota, for harbors largest collection microorganisms. Gut includes bacteria, viruses, protozoa, archaea, fungi in gastrointestinal tract,...
Malnutrition is a common complication in the dialysis population, both hemodialysis and peritoneal (PD). We report our exploratory study on characteristics of intestinal microbiota nutritional status PD patients. The patients were evaluated, their feces collected for 16S rRNA gene V3-V4 regions amplification high-throughput sequencing. differences between well-nourished (W) malnourished (M) groups compared. studied genera operational taxonomic units (OTUs) within genus patients, initially...
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease high mortality in East Aisa, especially China. To predict the prognosis of SFTS precisely important clinical practice.From May 2013 to November 2015, 233 suspected patients were tested for virus using RT-PCR. Cox regression model was utilized comfirm independent risk factors mortality. A score constructed based on coefficient factors. Log-rank test used evaluate significance this model.One hundred...
Abstract The current study aimed to analyze the clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) and explore risk factors critical patients. From 2016 2018, we collected hospitalized diagnosed cases SFTS in Jinan infectious disease hospital Shandong University analyzed by descriptive epidemiological method. According prognosis, they were divided into general group group. characteristics, features, laboratory indexes these 2 groups patients compared at first...
Abstract BACKGROUND Bazi Bushen is a Chinese patented medicine with multiple health benefits and geroprotective effects, yet, no research has explored its effects on intestinal homeostasis. In this study, we aimed to investigate the effect of inflammation potential mechanism gut microbiota dysbiosis homeostasis in senescence‐accelerated mouse prone 6 (SAMP6). The hematoxylin eosin (H&E) staining immunohistochemistry were performed assess function mucosal barrier. enzyme‐linked...
Jingmen tick virus (JMTV) is a newly identified segmented flavivirus that has been recognized in multiple hosts, such as humans, buffalos, bats, rodents, mosquitos and ticks. Various clinical cases studies manifested JMTV true arbovirus with wide host spectrum showed potential threats toward public health. reported countries Asia, Europe, Africa, America. Moreover, wild boars serve an important intermediary between humans the ecological system. In China, it nine provinces, while prevalence...
The functions and profiles of lncRNAs during infectious bursal disease virus (IBDV) infection have not been determined, yet. objectives this study were to determine the antiviral action loc107051710 lncRNA IBDV by investigating relationship between IRF8, Type I IFN, STATs, ISGs. DF-1 cells either left untreated as non-infected controls (n = 1) or infected with 3). RNA sequencing was applied for analysis mRNAs expression. Differentially expressed genes verified RT-qPCR. Then identification,...
Severe fever with thrombocytopenia syndrome (SFTS) usually demonstrates multi-organ injury a high mortality rate. This study aimed to investigate associations of serum aspartate/alanine aminotransferase (AST)/ALT, cytosolic AST (cAST)/ALT and mitochondrial (mAST)/ALT ratios the prognosis SFTS patients.A total 355 confirmed patients were included. Clinical laboratory data compared between survivors nonsurvivors. Logistic regression analysis was used assess independent risk factors for...
We aimed to compare the clinical efficacy of fecal microbiota transplantation (FMT) from same sex on ulcerative colitis (UC) patients. A total 272 UC patients were selected in prospective study, which incorporated four distinct groups, each comprising male and female patients, who either receiving FMT or placebo, respectively. was performed by sending gut healthy adolescents gender via gastroscope three times (one time/three weeks), a placebo used with an equal volume saline. Abdominal pain,...
Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease high fatality rate. Although several nomograms based on demographic and laboratory data have been reported to predict the prognosis of SFTS in recent studies, baseline serum glycated albumin (GA)/albumin (ALB) ratio included risk model has not evaluated for prediction clinical outcome. A total 214 patients integral admitted our hospital from May, 2020 November, 2022 were this study. infection was...
Severe fever with thrombocytopenia syndrome (SFTS) is a severe systemic virus infectious disease usually having multi-organ dysfunction which resembles sepsis.Data of 321 patients laboratory-confirmed SFTS from May 2013 to July 2017 were retrospectively analyzed. Demographic and clinical characteristics, calculated quick sequential organ failure assessment (qSOFA) score inflammatory response (SIRS) criteria for survivors nonsurvivors compared. Independent risk factors associated in-hospital...
Although ticks and tick-borne diseases are prevalent throughout China, there remains a knowledge gap regarding their biology potential risk of distribution to human animal populations on Chongming Island. The island, being China's third largest crucial component in the ecological preservation Yangtze Delta region, has yet be comprehensively studied this context.In study, employing molecular methodologies, significant prevalence Haemaphysalis (H.) longicornis H. flava - widely recognized for...
Kang‐Xian (KX) pills have been clinically used for the treatment of chronic hepatic injury (CHI). However, mechanisms KX on CHI remain unknown. The aim this study mainly focused anti‐inflammatory effects in a mouse model based modulating gut microbiota and permeability. We first established using carbon tetrachloride (CCl 4 ) treated it with KX. mice changes permeability after were also investigated. 16S rRNA analysis was to composition treatment. In addition, depleted combination...