Background: Recurrent respiratory tract infections (RRTIs) have a negative impact on both children's health and family wellbeing.Deficiency of ZhengQi used to be an instinct factor driving RRTI in Traditional Chinese Medicine (TCM).Our clinical observations suggest that children with gastrointestinal heat retention syndrome (GHRS) may greater risk catching (RTIs).GHRS is new predisposing for it dietary related.This study aimed explore association between GHRS RRTI.Methods: A prospective...

Abstract Background Increasing attention has been paid to the potential relationship between gut and lung. The bacterial dysbiosis in respiratory tract intestinal is related inflammatory response progress of lung diseases, pulmonary diseases could be improved by regulating microbiome. This study aims generate knowledge map identify major research hotspots frontier areas field gut–lung axis. Materials methods Publications axis from 2011 2021 were identified Web Science Core Collection....

Abstract BACKGROUND Hydrothermal carbonization has become a proficient technique to synthesize carbon materials from biomass owing its availability and environmental friendliness. Chrome‐tanned leather, waste that contains numerous functional groups, is potential adsorbent for separation of heavy metal ions. In the present work, phenolic‐functionalized hollow sponge‐like (HSLW) was synthesized leather via hydrothermal in presence tannin. This study aims develop novel uranium salt lake....

Intestinal flora plays an important role in inflammatory response to systemic or local organs of its host. High calorie diet has been shown aggravate the condition pneumonia and delay recovery, especially children. However, underlying mechanisms remain unclear. This study placed SPF rats a conventional environment, high LPS atomization was performed respectively combined. Analysis high-throughput sequencing intestinal content combined with animal weight, organ index, serum factors indicators...

Abstract Background Pneumonia is a common respiratory disorder, which brings an enormous financial burden to the medical system. However, current treatment options for pneumonia are limited because of drug resistance and side effects. Our previous study preliminarily confirmed that Yinlai Decoction (YD), prescription in clinical practice, can regulate expression inflammatory factors, but mechanisms unknown yet. Methods In our work, method named network pharmacology was applied, investigated...

Recurrent respiratory tract infections (RRTIs) are one of the most common diseases in children and adolescents. The causes RRTIs various. In addition to factors related infection, basic such as system, immune digestive system also involved. cost patients' frequent medical treatment hospitalization has been deemed be a heavy burden society family. China, traditional Chinese medicine (TCM) is commonly used treat RRTIs. TCM appraised effective, for reducing number hospital stays. Illustrious...

Background: Aims: Carboxylesterase (Ces)1f is implicated in protection against hepatic inflammation, but it unclear whether the enzyme has an influence polarization of Kupffer cells (KCs), innate immune mediating inflammatory injury including acute liver failure (ALF). In present study, we aim to explore KC induced by Ces1f mice with lipopolysaccharide/D‐galactosamine (LPS/D‐GalN)‐induced ALF. Methods: We adopted a novel delivery system, β‐1,3‐D‐glucan‐encapsulated Endoporter‐siRNA...

To explore the association between dietary habits and recurrent respiratory infection (RRI) in children aged 0–14 years. This case–control study compared data of with (cases) without RRI (controls) collected via structured questionnaire. Participants were recruited from Chinese medicine clinics, hospitals, children's learning institutions Beijing. A logistic regression analysis odds ratio (OR) calculations conducted using SPSS 17.0 software. total 241 questionnaires (case:control ratio:...

Gastrointestinal heat retention syndrome (GHRS) refers to a condition that is associated with increased gastrointestinal caused by metabolic block in energy. It common children and closely related the occurrence development of recurrent respiratory tract infection, pneumonia, functional abdominal pain, etc. However, there are no standardized diagnostic criteria differentiate GHRS. Therefore, this study aimed establish model for children's GHRS explore possible biological basis using systems...

Amplified spontaneous emission (ASE) is a critical factor that limits the output power of slab lasers. To suppress ASE effect in lasers, this paper proposes metal/dielectric broadband absorbing coating between laser gain medium and metal heat sink to from zero total internal reflection angle on facet inside medium. Based accurate characterization Cr thin films, Cr/SiO2 films for 1064 nm YAG lasers are designed fabricated ASE. The good agreement experiment design shows reliability

Low-density lipoprotein cholesterol (LDL-C) is acknowledged as an independent risk factor (IRF) for atherosclerotic cardiovascular disease. Nevertheless, studies on the impact of LDL-C microvasculature are still scarce. The retina, abundant in microvasculature, can now be examined microvascular alterations through novel, non-invasive, and quantitative optical coherence tomography angiography (OCTA) technique.

The Shenghua Decoction recorded in Fu Qing Zhu's Gynaecology,is a commonly used postpartum prescription,widely treating and gynecological diseases. However,its mechanism of action lower abdominal pain remains unclear. In this paper,network pharmacology was to explore the treatment abdomen pain,so as provide data support for better clinical application Decoction. drug targets were retrieved SymMap. String Cytoscape adopted enrichment analysis construct disease-drug-target biological network....

To examine the effects of accumulated heat in GI tract (AHGIT) on lung tissue protein expression pneumonic mice. Nebulized lipopolysaccharides (LPS) were administered to induce a mouse model (M1), and high-calorie/protein diet combined with nebulized LPS was used AHGIT pneumonia (M2). Isobaric tag for relative absolute quantitation (iTRAQ) proteomics applied study expression, followed by bioinformatics analysis. M1 mice developed alveolar damage prominent septum thickening, vascular...

To explore the mechanism of Yinlai Decoction (YD) intervening mice model FM1 influenza virus compound with high-fat and protein-diet by detecting survival rate, lung injury, expression inflammatory cytokines. A mouse was built. Mice were randomly divided to groups blank control, normal diet, (HPD), Ribavirin, Shuanghuanglian, Xiaoer huashi Pill YD, all infected via nose after four days' protein-diet. The electrogastrography (EGG) recorded, as well serum levels gastrin plasma vasoactive...

Pediatric pneumonia is a common respiratory disease and Yinlai Decoction (YLD) commonly used treatment in China. We explored the anti-inflammatory mechanism of action this traditional Chinese medicine for pneumonia. studied, by experimentation, YLD treating according to network pharmacology. By comparing with dexamethasone (DXMS), we investigated efficacy induced lipopolysaccharide (LPS) juvenile rats. In an aqueous extract YLD, 22 chemical compounds were identified, among which 10 related...

Bushen Chengyun granule (BCG) is an empirical treatment for female infertility (FI) caused by low endometrial receptivity (LER) involving a poorly understood mechanism. In this study, network pharmacology was used to explore the potential therapeutic mechanism of BCG on FI LER. The corresponding herb targets were obtained conducting search in Traditional Chinese Medicine Systems Pharmacology Database and PubMed-reported literature. Disease from following databases: Comparative Toxicogenomics...

Background. We intended to explore the mechanism of Yinlai decoction in treatment lipopolysaccharide (LPS)-induced pneumonia from perspective intestinal flora. Methods. Thirty Sprague–Dawley rats were randomly assigned blank control group (N), (P), and (PT). The rat model was established using LPS inhalation (0.5 mg/mL, 5 mL, 30 min/day, 3 days). administered intragastrically (2 mL/100 g, Lung tissue pathology, organ indexes, serum inflammatory factors, tumor necrosis factor-alpha (TNF-α),...

To search for specific metabolites in the lungs of pneumonia rats fed with a high-calorie diet, as well explore changes lung young treated Yinlai Decoction (YD) and its effects on inflammation-related metabolic pathways. Lipopolysaccharides (LPS) special diet were used to induce Sprague Dawley (SD) simulate intestinal state infant pneumonia. Liquid chromatography-mass spectrometry technology (LC-MS/MS) was detect each group. Supervised orthogonal partial least squares discriminant analysis...

To uncover the underlying mechanisms of action Yinlai decoction on high-calorie diet-induced pneumonia through proteomics analysis. Based Gene Expression Omnibus (GEO) database, lung tissue samples from normal and high-fat diet (HFD) mice in GSE16377 dataset were selected as test cohorts to identify differentially expressed genes conduct bioinformatics analyses. In animal experiments, randomly divided into control (N), (M), treatment (Y) groups. Mice M group received feed a 0.5 mg/mL...

To investigate the association between gastrointestinal heat retention syndrome (GHRS) and adult chronic eczema. This case–control study compared GHRS/GHRS accompanied by damp-heat (GHRS-DHS) other patient characteristics subjects with (cases) without eczema (controls) to identify potential factors associated this condition. Semi-structured questionnaires were used collect data via face-to-face interviews. Participants recruited from Dongzhimen Hospital affiliated Beijing University of...