A5073154569- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Healthcare Technology and Patient Monitoring
- Immune cells in cancer
- Neonatal Respiratory Health Research
- Climate Change and Health Impacts
- COVID-19 impact on air quality
- COVID-19 Impact on Reproduction
- Air Quality and Health Impacts
- Heart Rate Variability and Autonomic Control
- Extracellular vesicles in disease
- Vitamin C and Antioxidants Research
- Vitamin K Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammatory Biomarkers in Disease Prognosis
- Pneumothorax, Barotrauma, Emphysema
- Eicosanoids and Hypertension Pharmacology
- Circadian rhythm and melatonin
The Ohio State University
2015-2024
Lung Institute
2023-2024
National Heart Lung and Blood Institute
2024
The Ohio State University Wexner Medical Center
2014-2024
National Dairy Research Institute
2023
Mayo Clinic in Florida
2013-2016
Mayo Clinic
2013-2015
WinnMed
2012
Bridgeport Hospital
2012
Rapid and specific antibody testing is crucial for improved understanding, control, treatment of COVID-19 pathogenesis. Herein, we describe apply a rapid, sensitive, accurate virus neutralization assay SARS-CoV-2 antibodies. The based on an HIV-1 lentiviral vector that contains secreted intron Gaussia luciferase (Gluc) or nano-luciferase reporter cassette, pseudotyped with the spike (S) glycoprotein, validated plaque-reduction using authentic, infectious strain. was used to evaluate...
It is unclear whether extracorporeal CO
Objective: Acute respiratory distress syndrome is a common complication of critical illness, with high mortality and limited treatment options. Preliminary studies suggest that potentially preventable hospital exposures contribute to acute development. We aimed determine the association between specific rate development among at-risk patients. Design: Population-based, nested, Matched case-control study. Patients: Consecutive adults who developed from January 2001 through December 2010...
Specialized pro-resolving mediators (SPMs), including lipoxins derived from arachidonic acid and resolvins, protectins, maresins docosahexaenoic (DHA) eicosapentaenoic (EPA), orchestrate the active resolution of inflammation. These SPMs are biosynthesized through coordinated interaction various cells in a process known as transcellular biosynthesis, involving sequential action cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), 12-lipoxygenase (12-LOX), and/or 15-lipoxygenase (15-LOX) enzymes....
The management of severe and refractory hypoxemia in critically ill adult patients is practice based. Variability across individual practitioners institutions not well documented.To conduct a nationwide survey critical care physicians the United States regarding accepted definitions strategies for hypoxemia.A web-based was distributed to stratified random sample intensivists listed American Medical Association Physician Masterfile. generated by using mixed-methods approach.In survey, 4,865...
Introduction The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-19 and contributes to patient morbidity mortality. ARDS heterogeneous caused by various insults, results in hypoxemic failure. Patients with from may represent subgroup patients distinct molecular profiles that drive disease outcomes. Here, we hypothesized longitudinal transcriptomic analysis identify dynamic pathobiological pathways during ARDS. Methods We identified cohort an existing ICU...
Evidence suggests that COVID-19 predisposes to cardiovascular diseases (CVDs). While monocytes/macrophages play a central role in the immunopathogenesis of atherosclerosis, less is known about their immunopathogenic mechanisms lead CVDs during COVID-19. Natural killer (NK) cells, which an intermediary pathologies like are dysregulated Here, we sought investigate altered immune cells and associations with CVD risk severe
Abstract Background Convalescent plasma is being used widely as a treatment for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of COVID-19 convalescent unclear. Methods The Pass ive I mmunity T rial O ur N ation (PassITON) multicenter, placebo-controlled, blinded, randomized trial conducted in USA to provide high-quality evidence on adults hospitalized with symptomatic disease. Adults respiratory symptoms less than 14 days are eligible. Enrolled patients 1:1 ratio 1 unit...
Rationale: The nature, variability, and extent of early warning clinical practice alerts derived from automated query electronic health records (e-alerts) currently used in acute care settings for or research is unknown.Objectives: To describe e-alerts current use at medical centers participating a nationwide critical network.Methods: We surveyed investigators 38 institutions involved the National Institutes Health–funded Clinical Trials Network Prevention Early Treatment Acute Lung Injury...
Background: Convalescent plasma increases SARS-CoV-2 clearance in COVID-19, especially patients lacking pre-existing antibodies.Research Question: In hospitalized COVID-19 receiving convalescent plasma, does conversion to a positive IgG status provide mortality benefit who lacked IgG.Study Design and Methods: This observational study included consecutive with received under the Expanded Access Program from April August of 2020.SARS-CoV-2 N-based antibody ELISA measurements before after...
Objectives: Patients with severe, persistent hypoxemic respiratory failure have a higher mortality. Early identification is critical for informing clinical decisions, using rescue strategies, and enrollment in trials. The objective of this investigation was to develop validate prediction model accurately timely identify patients severe at high risk death, whom novel strategies can be efficiently evaluated. Design: Electronic medical record analysis. Setting: Medical, surgical, mixed ICU...
ABSTRACT Rapid and specific antibody testing is crucial for improved understanding, control, treatment of COVID-19 pathogenesis. Herein, we describe apply a rapid, sensitive, accurate virus neutralization assay SARS-CoV-2 antibodies. The new based on an HIV-1 lentiviral vector that contains secreted intron Gaussia luciferase or Nano-luciferase reporter cassette, pseudotyped with the spike (S) glycoprotein, validated plaque reduction using authentic, infectious strain. was used to evaluate...
<h3>BACKGROUND:</h3> Subjects with severe hypoxemic respiratory failure have shown a high mortality in previous studies. <h3>METHODS:</h3> All adult ICU patients requiring mechanical ventilation from 2005 to 2010 at Mayo Clinic were screened for hypoxemia (Murray lung injury score of ≥ 3). Extracorporeal membrane oxygenation, prone positioning, high-frequency oscillatory (HFOV), and inhaled vasodilators considered as rescue strategies. A propensity-based scoring was created the indication or...
<h3>BACKGROUND:</h3> Liberal oxygenation during mechanical ventilation is harmful in critically ill patients and certain subsets of patients, including those with stroke, acute myocardial infarction, cardiac arrest. Surveillance through electronic medical records improves safety the ICU. To date, this practice has not been used for oxygen titration (<math xmlns="http://www.w3.org/1998/Math/MathML" id="i1" display="inline" overflow="scroll"><mrow><msub><mi...
Introduction: Electronic surveillance in the intensive care unit have improved processes of including early weaning, limiting ventilator induced injury etc. However, it has not been used for oxygen (FiO2) titration adults, where exposure to high FiO2 levels can be seen due varied practices. Hypothesis: An electronic system with a decision support tool respiratory therapists implemented detect hyperoxia and is safe titration. Methods: alerts were generated by “Sniffer”, real-time in-house...