A5035224040- Gene expression and cancer classification
- Genetic factors in colorectal cancer
- Cardiovascular Health and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Suicide and Self-Harm Studies
- Molecular Biology Techniques and Applications
- Head and Neck Cancer Studies
- Environmental Justice and Health Disparities
- Hematopoietic Stem Cell Transplantation
- Pancreatic and Hepatic Oncology Research
- Statistical Methods and Inference
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Emergency and Acute Care Studies
- Air Quality and Health Impacts
- Health disparities and outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Heavy Metal Exposure and Toxicity
- Bioinformatics and Genomic Networks
- Diet and metabolism studies
- Cleft Lip and Palate Research
The Ohio State University
2016-2025
Nationwide Children's Hospital
2019-2025
The Ohio State University Wexner Medical Center
2018-2024
Henry Ford Health System
2023
Columbus Center
2021-2023
Worthington City School District
2023
Ohio University
2022-2023
Wake Forest University
2022
Faulkner University
2022
Creative Commons
2022
The R package clValid contains functions for validating the results of a clustering analysis. There are three main types cluster validation measures available, "internal", "stability", and "biological". user can choose from nine algorithms in existing packages, including hierarchical, K-means, self-organizing maps (SOM), model-based clustering. In addition, we provide function to perform tree algorithm (SOTA) method Any combination methods be requested single call. This allows simultaneously...
In Brief Objective: To evaluate our experience with more than 500 minimally invasive hepatic procedures. Summary Background Data: Recent data have confirmed the safety and efficacy of liver surgery. Despite these reports, no programmatic approach to surgery has been proposed. Methods: We retrospectively reviewed all patients who underwent a procedure for management tumors between January 2001 April 2008. Patients were divided into 3 groups: laparoscopy intraoperative ultrasound biopsy only,...
High-level occupational exposures to some industrial chemicals have been associated with liver diseases, including nonalcoholic fatty disease (NAFLD). However, the potential role of low-level environmental pollution on in general population has not evaluated.We determined whether pollutants are an elevation serum alanine aminotransferase (ALT) activity and suspected NAFLD U.S. adults.This cross-sectional cohort study evaluated adult participants without viral hepatitis, hemochromatosis, or...
To identify potential differential changes in youth suicide deaths associated with the coronavirus disease (COVID-19) pandemic to better inform prevention strategies.
Nuclear Factor of Activated T-cells (NF-AT) is a crucial transcription factor required for T-cell expression interleukin 2. Purified NF-AT contains 45-kDa and 90-kDa subunits (Corthesy, B., Kao, P. N. (1994) J. Biol. Chem. 269, 20682-20690). Partial internal amino acid sequences derived from each subunit indicate that these proteins are novel. The were used to clone the cDNAs encoding subunit. predict novel structures: NF45 has limited similarity prokaryotic sigma-54 human DNA topoisomerase...
Although nonalcoholic steatohepatitis (NASH) is typically associated with obesity, it has also been reported to occur in lean individuals exposed industrial chemicals. Occupational exposure vinyl chloride (VC) a well-documented risk factor for hemangiosarcoma, but not previously steatohepatitis. Here we evaluate liver biopsies from 25 nonobese, highly VC workers Next, metabolic and cytokine abnormalities affected controlled by 26 chemical no minimal exposures, 11 unexposed, healthy...
Hospital length of stay (LOS) and time for a patient to reach clinical stability (TCS) have increasingly become important outcomes when investigating ways in which combat Community Acquired Pneumonia (CAP). Difficulties arise deciding how handle in-hospital mortality. Ad-hoc approaches that are commonly used event with mortality can give disparate results provide conflicting conclusions based on the same data. To ensure compatibility among studies these outcomes, this type data should be...
OBJECTIVE The prognostic value of long-term glycemic variability is incompletely understood. We evaluated the influence visit-to-visit (VVV) fasting blood glucose (FBG) on incident cardiovascular disease (CVD) and mortality. RESEARCH DESIGN AND METHODS conducted a prospective cohort analysis including 4,982 participants in Antihypertensive Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) who attended baseline, 24-month, 48-month visits. VVV FBG was defined as SD or independent...
Griffithsin (GRFT) is a red-alga-derived lectin that binds the terminal mannose residues of N-linked glycans found on surface human immunodeficiency virus type 1 (HIV-1), HIV-2, and other enveloped viruses, including hepatitis C (HCV), severe acute respiratory syndrome coronavirus (SARS-CoV), Ebola virus. GRFT displays no T-cell mitogenic activity does not induce production proinflammatory cytokines in treated cell lines. However, despite growing evidence showing broad-spectrum nanomolar or...
<h3>Importance</h3> Timely outpatient follow-up care after psychiatric hospitalization is an established mental health quality indicator and considered important component of suicide prevention, yet little known about whether associated with a reduced risk soon hospital discharge. <h3>Objective</h3> To evaluate receipt within 7 days discharge subsequent among child adolescent inpatients examine factors timely care. <h3>Design, Setting, Participants</h3> This population-based, retrospective,...
Background Higher scores for the American Heart Association Life's Essential 8 (LE8) metrics, blood pressure, cholesterol, glucose, body mass index, physical activity, smoking, sleep, and diet, are associated with lower risk of chronic disease. Socioeconomic status (SES; employment, insurance, education, income) is LE8 scores, but there limited understanding potential differences by sex. This analysis quantifies association SES each sex, within Hispanic Americans, non‐Hispanic Asian Black...
Background: To define whether elderly patients hospitalized with community-acquired pneumonia (CAP) had better outcomes if they were treated empirical antimicrobial therapy adherent to the 2007 Infectious Diseases Society of America (IDSA)/American Thoracic (ATS) guidelines for CAP.
Abstract Background Gene expression data frequently contain missing values, however, most down-stream analyses for microarray experiments require complete data. In the literature many methods have been proposed to estimate values via information of correlation patterns within gene matrix. Each method has its own advantages, but specific conditions which each is preferred remains largely unclear. this report we describe an extensive evaluation eight current imputation on multiple types...
Normalization is an essential step with considerable impact on high-throughput RNA sequencing (RNA-seq) data analysis. Although there are numerous methods for read count normalization, it remains a challenge to choose optimal method due multiple factors contributing variability that affects the overall sensitivity and specificity. In order properly determine most appropriate normalization methods, critical compare performance shortcomings of representative set routines based different...
High throughput metabolomics makes it possible to measure the relative abundances of numerous metabolites in biological samples, which is useful many areas biomedical research. However, missing values (MVs) datasets are common and can arise due both technical reasons. Typically, such MVs substituted by a minimum value, may lead different results downstream analyses.Here we present modified version K-nearest neighbor (KNN) approach accounts for truncation at i.e., KNN (KNN-TN). We compare...
The extracellular matrix (ECM) consists of diverse components that work bidirectionally with surrounding cells to create a responsive microenvironment. In some contexts (e.g., hepatic fibrosis), changes the ECM are well recognized and understood. However, it is becoming increasingly accepted proteome (i.e., matrisome) responds dynamically stress before fibrosis. term "transitional tissue remodeling" describes qualitative quantitative in response injury do not alter overall architecture...
Endocrine and metabolism disrupting chemicals (EDCs/MDCs) have been associated with environmental liver diseases including toxicant-associated steatohepatitis (TASH). TASH has previously characterized by hepatocellular necrosis, disrupted intermediary metabolism, inflammation. Polychlorinated biphenyls (PCBs) are EDCs/MDCs the genesis progression of in animal models human injury epidemiology studies. The cross-sectional Anniston Community Health Survey (ACHS) investigates ortho-substituted...