A5054721345- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Cleft Lip and Palate Research
- Reconstructive Facial Surgery Techniques
- Cancer Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Esophageal Cancer Research and Treatment
- Facial Trauma and Fracture Management
- Tracheal and airway disorders
- Oral health in cancer treatment
- Nerve Injury and Rehabilitation
- Lung Cancer Treatments and Mutations
- Oral Health Pathology and Treatment
- Cancer Immunotherapy and Biomarkers
- Hearing, Cochlea, Tinnitus, Genetics
- Lung Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Facial Nerve Paralysis Treatment and Research
- Hearing Loss and Rehabilitation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ and Tissue Transplantation Research
- Dental Implant Techniques and Outcomes
The Ohio State University Wexner Medical Center
2016-2025
The Ohio State University
2016-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2015-2024
University of California, San Diego
2022-2024
University of Montana
2023
American Academy of Otolaryngology — Head and Neck Surgery
2023
Temple University
2023
AID Atlanta
2023
Harvard University
2023
Miller Children's & Women's Hospital
2022
Objective To (1) determine the overall complication rate, wound healing, and infection complications (2) identify preoperative, intraoperative, postoperative predictors of these complications. Study Design Case series with chart review. Setting Tertiary academic cancer hospital. Subjects Methods All head neck free flap patients at The Ohio State University (2006-2012) were assessed. Multivariable logistic regression assessed impact patient factors, intraoperative factors on aforementioned...
Abstract Objective We aim to more accurately characterize the current distribution and rates of squamous cell carcinoma (SCC) cases across various oral cavity subsites in United States. Study Design Retrospective cohort. Setting Database study evaluating cancer incidence States from 2001 2017. Methods utilized US Cancer Statistics Public Use Database, which includes deidentified data reported Centers for Disease Control Prevention's National Program Registries Institute's SEER (Surveillance,...
BACKGROUND Exome and targeted sequencing studies have identified potential driver mutations for a variety of tumor types. Cutaneous squamous cell carcinoma (cSCC) is one the most highly mutated cancers but typically associated with low rates metastasis high survival rates. Nevertheless, metastatic cSCC significant health threat; up to 8800 individuals die each year this disease. METHODS Because it difficult predict which cSCCs are more likely metastasize, because best authors' knowledge...
The purpose of this study was to further define the impact primary surgery in management oropharyngeal squamous cell carcinoma (SCC).Two hundred ninety-six patients with SCC treated were included. Multivariable analysis and recursive partitioning (RPA) identified predictors survival gastrostomy tube presence.Multivariable that HPV negativity (p = .0002), presence extranodal extension .0025), advanced T classification .0081) independent survival. For HPV-positive patients, surgical approach...
Postoperative delirium (POD) is associated with an increased rate of adverse events, higher health care costs, and longer hospital stays. At present, limited data are available regarding the risk factors for developing POD in patients undergoing head neck free flap reconstruction. Identification at high will allow implementation risk-mitigation strategies.To determine frequency reconstruction secondary to disease.This retrospective cohort study included 515 from January 1, 2006, through...
Complexities in cell-type composition have rightfully led to skepticism and caution the interpretation of bulk transcriptomic analyses. Recent studies shown that deconvolution algorithms can be utilized computationally estimate proportions from gene expression data blood samples, but their performance when applied tumor tissues, including those head neck, remains poorly characterized. Here, we use single-cell (~6000 single cells) collected 21 neck squamous cell carcinoma (HNSCC) samples...
In the recent years, prevalence of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly. Currently, nearly 80-90% all oropharynx tumors are HPV-positive. addition, it is now recognized that tumor status associated with good prognosis and improved response to chemoradiation. However, within this setting, there still patients OPSCC who will experience recurrence. With increasing incidence HPV-mediated OPSCC, recurrent HPV disease also becoming more prevalent...
Flow-through flaps (FTFs) are an advanced technique in which a free flap is anastomosed to the pedicle of another reconstruct extensive head and neck defects when recipient vessels scarce.
Perception of electrical stimuli varies widely across users cochlear implants and stimulation sites in individual users. It is commonly assumed that the ability subjects to detect discriminate signals dependent, part, on conditions implanted cochlea, but evidence supporting hypothesis sparse. The objective this study was define specific relationships between survival tissues near electrodes functional responses those electrodes. Psychophysical neurophysiological procedures were used assess...
Abstract Background When locoregional flaps fail to reconstruct the skull base, microvascular surgeon faces several reconstructive challenges. We present our technique and results of salvage anterior base reconstruction utilizing vastus lateralis free tissue transfer (VLFTT). Methods Four patients with defects after previous flap failure underwent VLFTT. Results The success rate was 100%. Complete separation intracranial sinonasal cavities achieved in all patients; thus, resolving...
Background Human papillomavirus (HPV)–mediated oropharyngeal cancer (OPC) is associated with dramatically improved survival in comparison HPV‐negative OPC and can be successfully treated surgical nonsurgical approaches. National treatment trends for were investigated the Cancer Data Base (NCDB). Methods The NCDB was reviewed primary HPV‐mediated 2010‐2014. Multivariable regression used to identify predictors of both therapy receipt adjuvant chemoradiation (CRT). Results There 13,363 patients...