A5013807246- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Reconstructive Surgery and Microvascular Techniques
- Obstructive Sleep Apnea Research
- Cancer Diagnosis and Treatment
- Anesthesia and Pain Management
- Endometriosis Research and Treatment
- Pain Management and Opioid Use
- Uterine Myomas and Treatments
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Pediatric Pain Management Techniques
- Smoking Behavior and Cessation
- Colorectal and Anal Carcinomas
- Reconstructive Facial Surgery Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Opioid Use Disorder Treatment
- Health Literacy and Information Accessibility
- Dietary Effects on Health
- Dental Radiography and Imaging
- Artificial Intelligence in Healthcare and Education
- Gynecological conditions and treatments
Thomas Jefferson University Hospital
2020-2025
Thomas Jefferson University
2019-2025
Jefferson University Hospitals
2021-2023
Kaiser Permanente
2020
Los Angeles Medical Center
2020
Subscription RequiredScientific InvestigationsEvaluating ChatGPT responses on obstructive sleep apnea for patient education Daniel J. Campbell, MD, Leonard E. Estephan, Eric V. Mastrolonardo, Dev R. Amin, Colin T. Huntley, Maurits S. Boon, MD Department of Otolaryngology – Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, PA Search more papers by this author , Published Online:July 24, 2023https://doi.org/10.5664/jcsm.10728
ChatGPT, an artificial intelligence (AI) chatbot, is the fastest growing consumer application in history. Given recent trends identifying increasing patient use of Internet sources for self-education, we seek to evaluate quality ChatGPT-generated responses education on thyroid nodules.
Importance For patients treated with immune checkpoint inhibitors (ICIs), recent data suggest that obesity has a beneficial effect on survival outcomes in various cancer types. Reports this association head and neck are limited. Objectives To compare overall (OS) to 5 years functional squamous cell carcinoma (HNSCC) ICIs based pretreatment body mass index (BMI). Design, Setting, Participants This retrospective population-based cohort study used obtained from the TriNetX Global Collaborative...
Flow-through flaps (FTFs) are an advanced technique in which a free flap is anastomosed to the pedicle of another reconstruct extensive head and neck defects when recipient vessels scarce.
<p>Supplementary Appendix</p>
<p>Supplement Figure 1: Waterfall Plots. A: Degree of pathologic treatment response (pTR) at the lymph nodes. B: primary site, stratifed by arm. C: RECIST tumor site (yellow) and nodes (purple), arm.</p>
<div>AbstractPurpose:<p>We evaluated whether indoleamine 2,3-dioxygenase (IDO1) inhibitor (IDOi) BMS986205 + PD-1 nivolumab enhanced T-cell activity and augmented immune-mediated antitumor responses in untreated, resectable head neck squamous cell carcinoma (HNSCC). We employed response-adaptive surgical timing to identify responders immunotherapy enhance their response.</p>Patients Methods:<p>Patients with HNSCC were 3:1 randomized receive or without orally daily...
<p>Supplement Figure 4: STRING Networks enlarged. The networks of B cell (A) and CAF (B) as visualized in 5.</p>
<p>Supplement Figure 3: Signature-based Biomarkers. A: Signature-Based biomarkers for HPV negative patients. B: positive ‘Primary Path Response’ refers to analysis based on the pTR at primary site alone. ‘Overall path response’ + lymph node response.</p>
<p>Supplementary Figure 2: Effect of IDO inhibitor BMS986205 on response rate and the tryptophan kynurenine pathway. A B: IDO1 gene expression levels pathway activity score, respectively, compared between baseline samples responders (R) non-responders (NR) nivolumab + nivolumab-only therapies. C: Tryptophan score post-treatment R NR - ns, *p < 0.05, **p 0.01, ***p 0.001.</p>
Studies investigating the clinical benefits of obesity across various cancer types are limited. This big data study demonstrates that is associated with improved overall survival up to 5 years after treatment immune checkpoint inhibition solid tumor malignancies.
Importance Due to lack of data from high-powered randomized clinical trials, the differences in functional and survival outcomes for patients with oropharyngeal squamous cell carcinoma (OPSCC) undergoing primary transoral robotic surgery (TORS) vs radiation therapy and/or chemoradiation (RT/CRT) are unclear. Objectives To compare 5-year (dysphagia, tracheostomy dependence, gastrostomy tube dependence) survivorship T1-T2 OPSCC receiving TORS RT/CRT. Design, Setting, Population This national...
Health care providers play a pivotal role as educators on health-related matters ranging from vaccination to smoking cessation. With the rising popularity of electronic cigarettes (e-cigarettes), face new challenge. To date, studies have identified general lack knowledge among regarding e-cigarettes and discomfort with counseling patients e-cigarette use. This study aims systematically explore perspectives different health their implications. growing availability research consequences use,...
Patients are increasingly relying on YouTube for health information. We objectively evaluated the quality and comprehensiveness of sialendoscopy videos available to patients. further investigated relationship between video content popularity.
Objectives/Hypothesis This study evaluated the quality and comprehensiveness of YouTube videos on hypoglossal nerve stimulation (HNS) for patients. also investigated relationship between video content, metrics, popularity. Study Design Cross‐sectional study. Methods We identified 150 using three search terms: “inspire sleep apnea,” “hypoglossal stimulation,” “upper airway stimulation.” Videos that were unrelated to use HNS obstructive apnea in adults, operating room recordings, lectures...
Objectives Mid and upper face free flaps frequently are associated with challenges due to pedicle length. We sought evaluate the frequency at which alternative maneuvers were required for these reconstructions determine if there was any association flap survival or postoperative complications. Study Design Retrospective review three tertiary care institutions. Methods Database review. Results Free reconstruction of midface performed in 295 patients (108 bony, 187 soft tissue). In 82% cases,...
Objectives: Little data is available on opioid usage in the adult population for benign oropharyngeal surgery. The objective here to evaluate prescribing patterns, consumption, and patient pain patterns following surgery, specifically tonsillectomy adenoidectomy, alone, expansion sphincter pharyngoplasty. Methods: Patients aged ≥18 years old received a tonsillectomy, or pharyngoplasty between November 2019 August 2020 were included. provided survey which included visual analog scale...
ABSTRACT Background Vessel grafting is an important technique in head and neck free tissue transfer (FTT) reconstruction when a tension‐free anastomosis not otherwise feasible. To our knowledge, there are limited data regarding interposition artery grafts for arterial anastomoses reconstruction. Here, we present multi‐institutional cohort of FTT defects. Methods A retrospective review was conducted at four tertiary care institutions patients who underwent defects which utilized graft the...