A5020710404- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Systemic Lupus Erythematosus Research
- Cancer Genomics and Diagnostics
- Thyroid Cancer Diagnosis and Treatment
- Animal Ecology and Behavior Studies
- Animal Behavior and Reproduction
- Metaheuristic Optimization Algorithms Research
- Evolutionary Algorithms and Applications
- Insect Utilization and Effects
- Cancer-related gene regulation
- Ecology and Vegetation Dynamics Studies
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Chromatin Remodeling and Cancer
- Gut microbiota and health
- RNA modifications and cancer
- Virus-based gene therapy research
- Nonmelanoma Skin Cancer Studies
- MicroRNA in disease regulation
- Cancer-related Molecular Pathways
- Advanced Multi-Objective Optimization Algorithms
The Ohio State University
2014-2024
Lund University
2020-2024
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2023
The Ohio State University Wexner Medical Center
2016-2022
University of Würzburg
2014-2019
Ohio University
2016
Meharry Medical College
2015
Trakya University
2014
Illumina (United States)
2013
University of Central Florida
2003-2006
Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and effective in chronic lymphocytic leukemia (CLL). Resistance to inhibitors resistance associated with BTK inhibition have not been characterized. Although only a small proportion patients had relapse during ibrutinib therapy, understanding mechanisms important. We evaluated relapsed disease identify mutations that may mediate resistance.
Abstract Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM) 1,2 . Here we report results a first-in-human phase I trial in 41 patients with rGBM who were injected CAN-3110—an oncolytic herpes virus (oHSV) 3 In contrast to other clinical oHSVs, CAN-3110 retains viral neurovirulence ICP34.5 gene transcribed by nestin promoter; is overexpressed GBM and invasive tumours, but not...
ABSTRACT Many insects utilise the polarisation pattern of sky to adjust their travelling directions. The extraction directional information from this sky-wide cue is mediated by specialised photoreceptors located in dorsal rim area (DRA). While part eye known be sensitive ultraviolet, blue or green component skylight, latter has only been observed active dim light. To address functional significance sensitivity, we define spectral and morphological adaptations DRA a nocturnal ball-rolling...
BACKGROUND Exome and targeted sequencing studies have identified potential driver mutations for a variety of tumor types. Cutaneous squamous cell carcinoma (cSCC) is one the most highly mutated cancers but typically associated with low rates metastasis high survival rates. Nevertheless, metastatic cSCC significant health threat; up to 8800 individuals die each year this disease. METHODS Because it difficult predict which cSCCs are more likely metastasize, because best authors' knowledge...
Catnip (Nepeta cataria) is a common garden herb well known for its euphoric and hallucinogenic effects on domestic cats,1-3 medicinal properties,4,5 as powerful repellent action insects.6,7 extracts have been proposed natural alternative to synthetic insect repellents, such N,N-diethyl-3-methylbenzamide (DEET),8,9 but how catnip triggers aversion in insects not known. Here, we show that, both Drosophila melanogaster flies Aedes aegypti mosquitoes, the major mediator of repellency widely...
Camponotus rufipes workers are characterized by an age-related polyethism. In the initial weeks of adult life, young perform tasks inside nest before they switch to multimodal foraging outside. We tested hypothesis that this transition is accompanied profound adaptations in peripheral and central visual systems. Our results show C. all ages (between 1 42 days) express three genes encoding for ultraviolet (UV), blue (BL), long-wavelength (LW1) sensitive opsins their retina, which likely...
Technologic advances have enabled the comprehensive analysis of genetic perturbations in non-small-cell lung cancer (NSCLC); however, African Americans often been underrepresented these studies. This ethnic group has higher incidence and mortality rates, some studies suggested a lower epidermal growth factor receptor mutations. Herein, we report most in-depth molecular profile NSCLC to date.A custom panel was designed cover coding regions 81 NSCLC-related genes 40 ancestry-informative...
The incidence of colorectal cancer (CRC) in young adults (age diagnosis < 50 years old) has been rapidly increasing. Although ~20% early-onset (EO) CRC cases are due to germline mutations, the etiology majority EOCRC remains poorly understood. Non-genetic factors such as environmental exposure and lifestyle changes likely have a direct link increased sporadic EOCRC. We hypothesize that may be observable differences epigenome, microbiome immunome. sought address this by comparing DNA...
Background Osteosarcoma (OSA) is the most common bone tumor in children and dogs; however, no substantial improvement clinical outcome has occurred either species over past 30 years. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression play a fundamental role cancer. The purpose of this study was to investigate potential contribution miR-34a loss biology canine OSA, well-established spontaneous model human disease. Methodology principal findings RT-qPCR demonstrated...
Ants are a well-characterized insect model for the study of visual learning and orientation, but extent to which colour vision is involved in these tasks remains unknown. We investigated preference, memory retention Camponotus blandus foragers under controlled laboratory conditions. Our results show that C. exhibit strong innate preference ultraviolet (UV, 365 nm) over blue (450 green (528 wavelengths. The ants can learn discriminate nm from either 528 or 450 nm, independent intensity...
Summary Reasons for performing study Dysadhesion of laminar basal epithelial cells ( LBECs ) from the underlying dermis is central event leading to structural failure in equine laminitis. Although many studies sepsis‐related laminitis have reported multiple events occurring throughout lamellar tissue, there minimal information regarding signalling specifically . Objectives To determine during early stages carbohydrate‐induced Study design Experimental study. Methods Eight horses were given...
Metastatic medullary thyroid cancer (MTC) is incurable and FDA-approved kinase inhibitors that include oncogenic RET as a target do not result in complete responses. Association studies of human MTCs murine models suggest the CDK/RB pathway may be an alternative target. The objective this study was to determine if CDKs represent therapeutic targets for MTC define mechanisms activity. Using cells are either sensitive or resistant vandetanib, we demonstrate palbociclib (CDK4/6 inhibitor)...
Colour processing at early stages of visual pathways is a topic intensive study both in vertebrate and invertebrate species. However, it still unclear how colour learning memory formation affects an insect brain the peripheral high-order integration centres, whether associative experiences are reflected plasticity underlying neuronal circuits. To address this issue, we used Camponotus blandus ants as their proven capabilities, precisely controllable age experience, already known central...
RNA sequencing has become an increasingly affordable way to profile gene expression patterns. Here we introduce a workflow implementing several open-source softwares that can be run on high performance computing environment.Developed as tool by the Bioinformatics Shared Resource Group (BISR) at Ohio State University, have applied pipeline few publicly available RNAseq datasets downloaded from GEO in order demonstrate feasibility of this workflow. Source code is here: workflow:...
Background: Familial adenomatous polyposis (FAP) is a condition typically caused by pathogenic germline mutations in the APC gene. In addition to colon polyps, individuals with FAP have substantially increased risk of developing papillary thyroid cancer (PTC). Little known about events underlying this association, and prevalence somatic "second-hit" controversial. Methods: Whole-genome sequencing was performed on paired tumor normal DNA from 12 patients who developed PTC. Somatic mutation...
Unusual amongst dung beetles, Scarabaeus galenus digs a burrow that it provisions by making repeated trips to nearby pile. Even more remarkable is these beetles return home moving backwards, with pellet of between their hind legs. Here, we explore the strategy S. uses find its way home. We that, like many other insects, they use path integration calculate direction and distance If fail locate burrow, initiate distinct looping search behaviour starts characteristic sharp turn, have called...
Insects have evolved physiological adaptations and behavioral strategies that allow them to cope with a broad spectrum of environmental challenges contribute their evolutionary success. Visual performance plays key role in this Correlates between life style eye organization been reported various insect species. Yet, if how visual ecology translates effectively into different discrimination learning capabilities has less explored. Here we report results from optical analyses performed two...
Colour vision allows animals to use the information contained in spectrum of light control important behavioural decisions such as selection habitats, food or mates. Among arthropods, largest animal phylum, we find completely colour-blind species well with up 40 different opsin genes more than 10 spectral types photoreceptors, a large diversity optical methods shaping sensitivity, eyes colour systems looking into dorsal and ventral hemisphere, which males females see world colours. The shows...
Abstract The domestic cat is an important human companion animal that can also serve as a relevant model for ~250 genetic diseases, many metabolic and degenerative conditions, forms of cancer are analogous to disorders. MicroRNAs (miRNAs) play crucial role in biological processes their dysregulation has significant impact on cellular pathways linked variety diseases. While species already have well-defined characterized miRNAome, miRNAs not been carefully studied cats. As result, there no...
ABSTRACT The sun is the most prominent source of directional information in heading direction network diurnal, ball-rolling dung beetle Kheper lamarcki. If this celestial body occluded from beetle's field view, distribution relative weight between cues that remain shifts favour pattern polarised light. In study, we continue to explore interplay and polarisation as K. By systematically altering intensity degree two cues, effectively change reliability they appear beetle. response these...
Tumor specimens are often preserved as formalin-fixed paraffin-embedded (FFPE) tissue blocks, the most common clinical source for DNA sequencing. Herein, we evaluated effect of pre-sequencing parameters to guide proper sample selection targeted gene Data from 113 FFPE lung tumor were collected, and sequencing was performed. Libraries constructed using custom probes paired-end sequenced on a next generation platform. A PCR-based quality control (QC) assay utilized determine quality, ratio...
DNA topoisomerase II<i>α</i> protein (TOP2<i>α</i>) 170 kDa (TOP2<i>α</i>/170) is an important target for anticancer agents whose efficacy often attenuated by chemoresistance. Our laboratory has characterized acquired resistance to etoposide in human leukemia K562 cells. The clonal resistant subline K/VP.5 contains reduced TOP2<i>α</i>/170 mRNA and levels compared with parental aim of this study was determine whether microRNA (miRNA)-mediated mechanisms play a role drug via decreased...