A5065822531- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Palliative Care and End-of-Life Issues
- TGF-β signaling in diseases
- NF-κB Signaling Pathways
- CAR-T cell therapy research
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Economic and Financial Impacts of Cancer
- Cancer-related molecular mechanisms research
- Protease and Inhibitor Mechanisms
- Immune Response and Inflammation
- Global Cancer Incidence and Screening
Addgene
2023
ITMO University
2022
Engelhardt Institute of Molecular Biology
2018-2021
Lomonosov Moscow State University
2018-2019
Abstract Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM) 1,2 . Here we report results a first-in-human phase I trial in 41 patients with rGBM who were injected CAN-3110—an oncolytic herpes virus (oHSV) 3 In contrast to other clinical oHSVs, CAN-3110 retains viral neurovirulence ICP34.5 gene transcribed by nestin promoter; is overexpressed GBM and invasive tumours, but not...
Obesity and insulin resistance are the main factors in development of metabolic syndrome (MetS). In patients with MetS, there is an active accumulation free fatty acids liver, which may lead to disturbances homeostasis metabolism hepatocytes, thus resulting mitochondrial dysfunction, oxidative stress, cellular apoptosis. Mitochondrial dysfunction has been extensively studied context pathogenetic features syndrome. However, processes uncoupling remain unclear. (MU) a process associated...
Transforming growth factor beta (TGF-β) is the main cytokine responsible for induction of epithelial-mesenchymal transition breast cancer cells, which a hallmark tumor transformation to metastatic phenotype. Recently, research demonstrated that chemokine CCL2 gene expression level directly correlates with TGF-β activity in patients. attracts tumor-associated macrophages and is, therefore, considered as an important inductor progression; however, precise mechanisms underlying its regulation...
Cytokine interleukin 33 (IL-33) is constitutively expressed by epithelial barrier cells, and promotes the development of humoral immune responses. Along with other proinflammatory mediators released epithelium airways lungs, it plays an important role in a number respiratory pathologies. In particular, IL-33 significantly contributes to pathogenesis allergy asthma; genetic variations IL33 locus are associated increased susceptibility asthma. Large-scale genome-wide association studies have...
Interleukin 33 (IL-33) is a cytokine constitutively expressed by various cells of barrier tissues that contribute to the development inflammatory immune responses. According its function as an alarmin secreted lung and airway epithelium, IL-33 plays significant role in pathogenesis allergic disorders. strongly involved asthma, anaphylaxis, allergy dermatitis, genetic variations IL33 locus are associated with increased susceptibility asthma. Genome-wide association studies have identified...
Цель данного обзора — обобщить результаты исследований отношения пациентов к скринингу онкологических заболеваний. В рамках были изучены полные тексты 63 публикаций по четырём распространённым онкологическим заболеваниям: рак молочной железы, шейки матки, колоректальный и лёгкого. Для каждого заболевания отмечены особенности скрининговым мероприятиям, которые выражаются в их готовности проходить обследования, осведомлённости о заболевании скрининге на него, мотиваторах барьерах пути принятию...
<h3>Background</h3> Pancreatic cancer (PC) is one of the most aggressive types malignant tumors due to fact, that early stages disease are asymptomatic and difficult diagnose. Matrix metalloproteinases (MMP) play a key role in progression PC through proteolysis collagen range regulators promotes tumor invasion angiogenesis. MMPs considered as promising therapeutic targets, but MMP inhibitors exhibit significant efficacy exclusively narrow time window, makes it use them for prevention local...
An expansion of digital technologies in healthcare includes various artificial intelligence (AI) approaches to diagnostic, patient care, and research. This state-of-art review aims critically assess the current role AI public health. Furthermore, it explores overall progress determines possible direction expediency for health research projects areas that would benefit from AI. We paid particular attention describing biomedical data sources AI-based analysis technology advances radiology,...