A5069683747- Malaria Research and Control
- Geometric Analysis and Curvature Flows
- Geometry and complex manifolds
- Immune cells in cancer
- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Advanced Differential Geometry Research
- X-ray Diffraction in Crystallography
- Heavy Metal Exposure and Toxicity
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Tea Polyphenols and Effects
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Parkinson's Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- TGF-β signaling in diseases
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Glass properties and applications
University of Calcutta
2016-2025
University of California, Davis
2024
Jadavpur University
2024
Homi Bhabha National Institute
2023
Bhabha Atomic Research Centre
2023
Institute of Zoology
2021
University of Delhi
2005-2017
International Centre for Genetic Engineering and Biotechnology
2005-2017
University of Kalyani
1984-2013
Bose Institute
2003-2008
The study was planned to screen the marine actinobacterial extract for protease inhibitor activity and its anti- Pf under in vitro vivo conditions. Out of 100 isolates, only 3 isolates exhibited moderate high activities on trypsin, chymotrypsin proteinase K. Based were chosen further studies. potential isolate characterized by polyphasic approach identified as Streptomyces sp LK3 (JF710608). lead compound peptide from LK3. double-reciprocal plot displayed inhibition mode is non-competitive...
Tumor-associated macrophages are major contributors to malignant progression and resistance immunotherapy, but the mechanisms governing their differentiation from immature myeloid precursors remain incompletely understood. In this study, we demonstrate that exosomes secreted by human mouse tumor-educated mesenchymal stem cells (MSCs) drive accelerated breast cancer inducing of monocytic myeloid-derived suppressor into highly immunosuppressive M2-polarized at tumor beds. Mechanistically,...
Abstract Organometallic metal(arene) anticancer agents require ligand exchange for their activity and this is generally believed to confer low selectivity potential cellular targets. However, using an integrated proteomics‐based target‐response profiling approach as a potent hypothesis‐generating procedure, we found unexpected target of ruthenium(arene) pyridinecarbothioamide (plecstatin) plectin, scaffold protein cytolinker, which was validated in plectin knock‐out model vitro. Plectin...
Abstract Tumor cells promote immune evasion through upregulation of programmed death-ligand 1 (PD-L1) that binds with cell death protein (PD1) on cytotoxic T and dysfunction. Though therapeutic efficacy anti-PD1 antibody has remarkable effects different type cancers it is less effective in breast cancer (BC). Hence, more details understanding PD-L1-mediated necessary. Here, we report BC secrete extracellular vesicles form exosomes carry PD-L1 are highly immunosuppressive. Transforming growth...
Abstract Background Cadmium is one of the inflammation-related xenobiotics and has been regarded as a potent carcinogen. The relationship between inflammation cell proliferation due to chronic infection studied, but mechanism not fully clear. Though mode cadmium toxicity well characterized in animal cells, still it requires some further investigations. Previously we reported that induces immune death Swiss albino mice. In present study showed instead inducing mechanism, low concentration...
Stevioside is a diterpene glycoside found in the leaf of Stevia rebaudiana, traditional oriental medicinal herb, which has been shown to have various biological and ethno-medicinal activities including antitumor activity. In this study, we investigated effects stevioside on cytotoxicity, induction apoptosis, putative pathways its action human breast cancer cells (MCF-7). For analysis apoptotic pathway, measurement reactive oxygen species (ROS) assessment mitochondrial transmembrane potential...
This paper focuses on some geometrical and physical properties of a conformal η-Ricci soliton (Cη-RS) four-dimension Lorentzian Para-Sasakian (LP-S) manifold. The first section presents an introduction to Cη-RS LP-S manifolds, followed by discussion preliminary ideas about the LP-Sasakian In subsequent sections, we establish several results pertaining manifolds that exhibit Cη-RS. Additionally, consider certain conditions associated with manifolds. Besides these points view, this in perfect...
Summary Plasmodium vivax depends on interaction with the Duffy antigen/receptor for chemokines (DARC) invasion of human erythrocytes. The 140 kDa P. Duffy-binding protein (PvDBP) mediates DARC. receptor-binding domain PvDBP maps to its N-terminal, cysteine-rich region, region II (PvRII), which contains approximately 300 amino acid residues including 12 conserved cysteines. Using surface plasmon resonance, we show that binding PvRII DARC is a high-affinity constant (K(D)) 8.7 nM. minimal has...
Abstract Background Paraquat (1, 1-dimethyl-4, 4-bipyridium dichloride; PQ) causes neurotoxicity, especially dopaminergic and is a supposed risk factor for Parkinson's disease (PD). However, the cellular molecular mechanisms of PQ-induced neurodegeneration are far from clear. Previous studies have shown that PQ induces neuroinflammation cell loss, but prime cause those events still in debate. Methods We examined neuropathological effects not only substantia nigra (SN) also frontal cortex...
Abstract Japanese encephalitis virus (JEV), which is a causative agent of sporadic encephalitis, harbours itself inside the neural stem/progenitor cells. It well-known fact that JEV infects cells and decreases their proliferation capacity. With mass spectrometry-based quantitative proteomic study, it possible to reveal impact on stem at protein level. Our aim was perceive cell response upon viral challenge. We performed two-dimensional gel electrophoresis-based study human (hNS1 line) post...
Cancer-associated fibroblasts (CAFs) are known to impact on tumour behaviour, but the mechanisms controlling this poorly understood.Breast normal (NFs) or CAFs were isolated from cancers by laser microdissection cultured. Fibroblasts transfected manipulate miR-222 Lamin B receptor (LBR). The fibroblast-conditioned medium was collected and used treat epithelial BC lines MDA-MB-231 MDA-MB-157. Migration, invasion, proliferation senescence assessed using transwell, MTT X-gal assays,...
Elevated expression of chemokine receptors in tumors has been reported many instances and is related to a number survival advantages for tumor cells including abnormal activation prosurvival intracellular pathways. In this work we demonstrated an inverse correlation between levels p53 suppressor CXCR5 receptor MCF-7 human breast cancer cell line. Lentiviral transduction with shRNA led elevated at both mRNA protein levels. Functional activity p53-knockdown was also increased as shown by...
Literature suggests that tea (Camellia sinensis) is a potent therapeutic agent and acts against many skin diseases. L-theanine, also known as γ-glutamyl ethylamide, non-protein amino acid, naturally obtained from has structural similarity with the neurotransmitter glutamate. This study was conducted to evaluate role of in prevention 2,4-dinitrochlorobenzene (DNCB) mediated atopic dermatitis (AD) BALB/c mice. To achieve our goal, serological, histological, immunohistochemical behavioural...
Continuous free radical assault upsets cellular homeostasis and dysregulates associated signaling pathways to promote stress-induced cell death. In spite of the continuous development implementation effective therapeutic strategies, limitations in treatments for toxicities remain. The purpose present study was determine potential efficacy bacterial fucose polysaccharides against hydrogen peroxide (H2O2)-induced stress human lung fibroblast (WI38) cells understand molecular mechanisms. two...