A5086070436- Metal complexes synthesis and properties
- Tea Polyphenols and Effects
- Crystallization and Solubility Studies
- Crystal structures of chemical compounds
- X-ray Diffraction in Crystallography
- Immune Cell Function and Interaction
- Synthesis and Characterization of Heterocyclic Compounds
- Flavonoids in Medical Research
- Nanoparticles: synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Organometallic Compounds Synthesis and Characterization
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Environmental Toxicology and Ecotoxicology
- Phytochemicals and Medicinal Plants
- Medicinal Plant Pharmacodynamics Research
- RNA Interference and Gene Delivery
- Pesticide Exposure and Toxicity
- Phytoestrogen effects and research
- CRISPR and Genetic Engineering
- Fungal Biology and Applications
- Chemotherapy-induced organ toxicity mitigation
- MicroRNA in disease regulation
West Bengal State University
2014-2024
Bose Institute
2004-2011
Coriander, used as a common food seasoning, contains linalool the main constituent of its essential oil. In this study, we tested effect vis-à-vis that conventional chemotherapeutic drug, cyclophosphamide, against solid S-180 tumor-bearing Swiss albino mice. Tumor volume, cell count, cycle phase distribution, apoptosis, and proliferation markers indicate has potent antitumor activity. vitro in vivo data suggest induction oxidative stress might be responsible for anticancer linalool. However,...
Abstract Tumor hypoxia is positively correlated with tumor aggressiveness and hence a negative prognostic factor in cancer. As normal cells usually do not experience such low oxygen levels, hypoxic cell signaling has attracted significant attention for the development of tumor‐selective treatment strategies. In response to hypoxia, master transcriptional regulator, HIF‐1α plays central role cellular adaptation by transactivating several crucial downstream target genes, which are involved...
Cancer patients often exhibit loss of proper cell-mediated immunity and reduced effector T-cell population in the circulation. Thymus is a major site maturation, tumors induce thymic atrophy to evade cellular immune response. Here, we report severe hypocellularity along with decreased integrity tumor bearer. In an effort delineate mechanisms behind such atrophy, observed that tumor-induced oxidative stress played critical role, as it perturbed nuclear factor-kappaB (NF-kappaB) activity....
Patients with advanced cancer exhibit multifaceted defects in their immune capacity, which are likely to contribute an increased susceptibility infections and disease progression. We demonstrated earlier that curcumin inhibits tumor growth prevents cell death tumor-bearing hosts. Here we report tumor-induced immunodepletion involves apoptosis of thymic CD4+/CD8+ single/double positive cells as well loss circulating T cells. Administration animals resulted restoration progenitor, effecter, In...
Background: Loss of function the p53 gene is implicated in defective apoptotic responses tumors to chemotherapy. Although pro-apoptotic roles eugenol and capsaicin have been amply reported, their dependence on for apoptosis induction gastric cancer cells not well elucidated. The aim study was elucidate role by a human cell line, AGS. Materials Methods: AGS were incubated with or without various concentrations 12 hrs, presence absence siRNA. Cell cycling, annexin V expression related proteins...
Biological potential of a copper(<sc>ii</sc>) complex found to exhibit <italic>in vitro</italic> antiproliferative activity towards two cell lines, AGS and A549 cancer cells.
Biosynthesis of gold nanoparticles distinct geometric shapes with highly functional protein coats without additional capping steps is rarely reported. This study describes green synthesis protein-coated for the first time from edible, mycorrhizal fungus Tricholoma crassum (Berk.) Sacc. The were size range 5-25 nm and different shapes. Spectroscopic analysis showed red shift absorption maxima longer reaction period during production blue increase in pH. These characterized spectroscopy, SEM,...
Abstract Eucalyptol (EU) is a monoterpenoid found as an active compound of many plants such bay leaves, cardamom and also major constituent in eucalyptus oil. Although the anticancer activity eucalyptol has been reported few cancer cell lines, its effect on tumor metastasis not studied so far. Here, we have shown that EU anti-metastatic against skin cells vitro vivo. decreases migration invasion cells. Further, it reduces expression mesenchymal markers vimentin, snail, slug, twist, induces...
Two novel copper (II) substituted thiosemicarbazone Schiff base complexes [Cu(L1)(µ-SCN)]n(NO3)2 (1) and [Cu2(µ-SCN)(SCN)(L2)2](NO3) (2) have been synthesized by condensing thiosemicarbazides like 4-methyl-3-thiosemicarbazide or 4-ethyl-3-thiosemicarbazide with 2-acetylpyridine. Both the metal 1 2 are characterized using different spectroscopic techniques IR, UV-Vis, ESR spectroscopy followed elemental analysis, cyclic voltammetric measurement single crystal X-ray structure analysis....
Abstract Transforming growth factor β (TGFβ) is a prominent cytokine that promotes tumor progression by activating epithelial‐to‐mesenchymal transition (EMT). This study indicated TGFβ exerted metastasis inducing zinc finger E‐box binding homeobox 1 (ZEB1) and long noncoding RNA, LINC00273, expressions in A549 cells. Knocking down LINC00273 diminished induced ZEB1 expression as well metastasis. Mechanistically, acted molecular sponge of microRNA (miR)‐200a‐3p which liberate to perform its...
The transforming growth factor-β (TGF-β) signaling is considered to be a key player in gastric cancer metastasis, and the inhibition of TGF-β/SMAD4 pathway may novel strategy for therapeutic interventions cancer.
Accumulating evidence suggests that free radical reactions play a key part in the development of degenerative diseases and an antioxidant-rich diet is major defense against these reactions. In this study, we explore comparative antioxidant capacities extracts some commonly used Indian spices (anise, cardamom, Ceylon cinnamon, clove) along with their purified components (anethole, eucalyptol, cinnamaldehyde, eugenol, respectively). Eugenol shows highest 1,1-diphenyl-2-picrylhydrazyl,...
It is recognized that during cancer, the disease itself as well many of anticancer drugs in use produce undesirable side effects such hepatotoxicity. We have already demonstrated antitumor and immunorestoring black tea. Here we report Ehrlich's ascites carcinoma (EAC)—induced hepatotoxicity its protection by dose tea mice. Hepatotoxicity was adjudged liver histopathology measurement plasma level alkaline phosphatase (ALP). An attempt to delineate underlying mechanisms revealed tumor-induced...
Recently the anti-cancer role of black tea has gained immense importance. Nevertheless, signaling pathways underlying tea-induced tumor cell death are still unknown. Previously we reported that induces Ehrlich's ascites carcinoma (EAC) apoptosis by changing balance between pro-and anti-apoptotic proteins. It is now well accepted many converge at mitochondria to decrease mitochondrial transmembrane potential (MTP) thereby releasing apoptogenic proteins and resulting in activation effecter...