A5018109112- Organic Electronics and Photovoltaics
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Conducting polymers and applications
- Perovskite Materials and Applications
- Genetics, Aging, and Longevity in Model Organisms
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- Advanced Glycation End Products research
- Cancer Immunotherapy and Biomarkers
- Atmospheric chemistry and aerosols
- solar cell performance optimization
- Lymphatic System and Diseases
- Thin-Film Transistor Technologies
- Mesenchymal stem cell research
- Pain Mechanisms and Treatments
- Indoor Air Quality and Microbial Exposure
- Urinary and Genital Oncology Studies
- Head and Neck Cancer Studies
Addgene
2023-2025
Repligen (United States)
2023-2025
Harvard University
2017-2024
Korea Institute of Toxicology
2024
Boston VA Research Institute
2020-2024
Georgia Institute of Technology
2023
TU Dresden
2018-2021
Colorado State University
2016-2021
Chungnam National University
2008-2018
Kangwon National University
2017
Abstract Immunotherapy failures can result from the highly suppressive tumour microenvironment that characterizes aggressive forms of cancer such as recurrent glioblastoma (rGBM) 1,2 . Here we report results a first-in-human phase I trial in 41 patients with rGBM who were injected CAN-3110—an oncolytic herpes virus (oHSV) 3 In contrast to other clinical oHSVs, CAN-3110 retains viral neurovirulence ICP34.5 gene transcribed by nestin promoter; is overexpressed GBM and invasive tumours, but not...
Urothelial carcinoma, common in older adults, is rare younger populations and even less the prostatic urethra. Advanced disease typically managed with platinum-based chemotherapy, immune checkpoint inhibitors, targeted therapies. However, presentations young patients aggressive highlight need for innovative personalized treatment strategies. This case report presents a instance of metastatic urothelial carcinoma originating urethra 37-year-old male. Initial symptoms led to diagnosis through...
High mobility group box 1 protein (HMGB1), a nuclear protein, can be translocated to the cytoplasm and secreted in colon cancer cells. However, diagnostic significance of HMGB1 has not been evaluated colorectal carcinomas. For this purpose, we have screened expression secretion 10 cell lines control line found that was detected culture medium. To evaluate value HMGB1, performed an enzyme-linked immunosorbent assay measure levels compared them carcinoembryonic antigen (CEA) serum samples 219...
Conflict between the sexes over reproductive interests can drive rapid evolution of traits and promote speciation. Here we show that inter-species mating Caenorhabditis nematodes sterilizes maternal individuals. The principal effectors male-induced harm are sperm cells, which induce sterility shorten lifespan by displacing conspecific sperm, invading ovary, sometimes breaching gonad to infiltrate other tissues. This sperm-mediated is pervasive across species, but idiosyncrasies in its...
N,N-diethyl-meta-toluamide (DEET) is a commonly used synthetic insect repellent. Although the neurological effects of DEET have been widely investigated, its on germline are less understood. Here, we show that exposure nematode Caenorhabditis elegans, which highly predictive mammalian reprotoxicity, resulting in internal levels within range detected human biological samples, causes activation p53/CEP-1-dependent germ cell apoptosis, altered meiotic recombination, chromosome abnormalities,...
Mesonephric adenocarcinoma in males is an exceptionally rare malignancy arising from mesonephric remnants. Accurate diagnosis requires thorough histopathological and molecular analysis. A 33-year-old male presented with right lower quadrant pain, imaging revealed a pelvic mass compressing adjacent structures. Biopsy confirmed adenocarcinoma. Genetic profiling mutations tuberous sclerosis complex 2 (TSC2) phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha (PIK3CA), offering...
Two semiconducting conjugated polymers were synthesized via Stille polymerization. The structures combined unsubstituted or (triisopropylsilyl)ethynyl (TIPS)-substituted 2,6-bis(trimethylstannyl)benzo[1,2-b:4.5-b']dithiophene (BDT) as a donor unit and benzotriazole with symmetrically branched alkyl side chain (DTBTz) an acceptor unit. We investigated the effects of different BDT moieties on optical, electrochemical, photovoltaic properties film crystallinities carrier mobilities....
Four biphenyl- and fluorene-based o-carboranyl compounds, 4-[2-(p-n-butylphenyl)-1-o-carboran-1-yl]biphenyl (1B), 4,4″-bis[2-(p-n-butylphenyl)-1-o-carboran-1-yl]biphenyl (2B), 2-[2-(p-n-butylphenyl)-1-o-carboran-1-yl]fluorene (1F), 2,7-bis[2-(p-n-butylphenyl)-1-o-carboran-1-yl]fluorene (2F), were prepared fully characterized by multinuclear NMR spectroscopy elemental analysis. The crystal structures of 1B 2B, analyzed single-crystal X-ray diffraction, exhibited distinct distortions the...
Chemicals that are highly prevalent in our environment, such as phthalates and pesticides, have been linked to problems associated with reproductive health. However, rapid assessment of their impact on health understanding how they cause deleterious effects, remain challenging due fast-growing numbers the limitations various current toxicity model systems. Here, we performed a high-throughput screen C. elegans identify chemicals inducing aneuploidy result impaired germline function. We...
Kaposi Sarcoma (KS) is a vascular tumor originating from endothelial cells and associated with human herpesvirus 8 (KSHV) infection. It disproportionately affects populations facing health disparities. Although antiretroviral therapy (ART) has improved KS control in people HIV (PWH), treatment options for advanced remain limited. This study investigates the microenvironment (TME) of through whole-transcriptomic profiling, analyzing changes over time differences based on status. The TME was...
Abstract Dopants, i.e., electronically active impurities, are added to organic semiconductor materials control the material's Fermi level and conductivity, improve injection at device contacts, or fill trap states in layers interfaces. In contrast bulk doping as achieved by blending co‐deposition of dopant semiconductor, surface has a lower propensity introduce additional traps scattering centers even alter layer morphology relative undoped material layers. this study, electrical effects...
Exposure to diethylhexyl phthalate (DEHP), the most abundant plasticizer used in production of polyvinyl-containing plastics, has been associated adverse reproductive health outcomes both males and females. While effects DEHP on have widely investigated, molecular mechanisms by which exposure environmentally-relevant levels its metabolites impact female germline context a multicellular organism remained elusive. Using Caenorhabditis elegans as model for studying reprotoxicity, we show that...
HMGB1 is a nuclear protein that overexpressed and secreted in cancer cells. However, little known about the roles of cytoplasm secretory pathway To clarify this aspect function, we fractionated HCT116 colon cells used proteomic approach to analyze cytoplasmic HMGB1-binding proteins. Pull-down experiments using recombinant as bait, followed by mass spectrometry analysis identified 162 interacting Among them were 74 proteins be localized exclusively extra-nuclear region, 60 both extranuclear...
The series of novel salen-based indium complexes (3-tBu-5-R-salen)In-Me (3-tBu-5-R-salen = N,N'-bis(2-oxy-3-tert-butyl-5-R-salicylidene)-1,2-diaminoethane, R H (1), tBu (2), Br (3), Ph (4), OMe (5), NMe2 (6)) and [(3-tBu-5-NMe3-salen)In-Me](OTf)2 (7; OTf CF3SO3-) have been synthesized fully characterized by NMR spectroscopy elemental analysis. All 1-7 are highly stable in air even aqueous solutions. solid-state structures for 3-5, which were confirmed single-crystal X-ray analysis, exhibit...
Abstract Studies have shown an association between female infertility and exposure to endocrine-disrupting chemicals (EDCs), yet strategies for neutralizing such effects are lacking. Bisphenol A (BPA) is a prevalent EDC that affects... Endocrine-disrupting ubiquitously present in our environment, but the mechanisms by which they adversely affect human reproductive health circumvent their remain largely unknown. Here, we show Caenorhabditis elegans supplementation with antioxidant Coenzyme...
A novel light trapping configuration called a compound parabolic trapper (CPT) is proposed. CPT integrated with V-groove textured surface increases the power conversion efficiency of polymer solar cells from 9.38% to 10.4%. multiscale system applying schemes nanopatterned plasmonic PV improves it further 10.8%, achieving almost black absorption 94.1%. As service our authors and readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be...
Frameshift mutations in coding mononucleotide repeats (cMNR) are common tumors with high microsatellite instability (MSI-H). These generate mRNAs containing abnormal sequences and premature termination codons (PTC). Normally, PTCs degraded by nonsense-mediated mRNA decay (NMD). However, located the last exon not subject to degradation NMD (NMD-irrelevant). This study aimed discover whether genes frameshift truncated mutant proteins.We identified 66 cMNRs bioinformatic analysis. We found...
It is important to develop new donor (D)–acceptor (A) type low band gap polymers for highly stable polymer solar cells (PSCs). Here, we describe the synthesis and photovoltaic properties of two D–A polymers. The consist dithienobenzodithiophene (DTBDT) moieties with expanded conjugation side groups as donors 2-ethyl-1-(thieno[3,4-b]thiophen-2-yl)hexan-1-one (TTEH) or 6-octyl-5H-thieno[3′,4′:4,5]thieno[2,3-c]pyrrole-5,7(6H)-dione (DTPD) acceptors give pDTBDT-TTEH pDTBDT-DTPD polymers,...
Abstract The detailed mechanisms driving the development of natural killer (NK) cells from hematopoietic stem remain to be clearly elucidated. Here, we show that osteopontin (OPN) is a key factor for NK development. OPN-deficient mice evidenced severe impairments in bone marrow (BM) and spleen which populations express CD122 cell receptors were reduced. However, absence intrinsic OPN expression did not affect development, whereas microenvironment caused significant reduction population. was...
Doping is a powerful tool to control the majority charge carrier density in organic field-effect transistors and threshold voltage of these devices. Here, surface doping approach shown, where dopant deposited on prefabricated polycrystalline semiconducting layer. In this study, (tridecafluoro-1,1,2,2-tetrahydrooctyl)trichlorosilane (FTCS), fluorinated alkylsilane used as dopant, which solution processable much cheaper than conventional p-type dopants, such...
Current treatments for osteoporosis were prevention of progression, yet it has been questionable in the stimulation bone growth. The mesenchymal stem cells (MSCs) treatment aims to induce differentiation progenitor into bone-forming osteoblasts. We investigate whether human umbilical cord blood (hUCB)-MSCs transplantation may regeneration osteoporotic rat model induced by ovariectomy.The ovariectomized (OVX) group (n = 10) and OVX-MSCs underwent bilateral ovariectomy osteoporosis, while Sham...