A5040932380- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- Protein Degradation and Inhibitors
- Lymphatic System and Diseases
- Cancer Genomics and Diagnostics
- Hematological disorders and diagnostics
- Acute Lymphoblastic Leukemia research
- Biosensors and Analytical Detection
- Hematopoietic Stem Cell Transplantation
- Sarcoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- COVID-19 Clinical Research Studies
- Retinoids in leukemia and cellular processes
- CRISPR and Genetic Engineering
- COVID-19 diagnosis using AI
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
Presbyterian Hospital
2020-2024
New York Hospital Queens
2020-2024
NewYork–Presbyterian Hospital
2020-2024
Cornell University
2020-2024
Weill Cornell Medicine
2020-2024
Brigham and Women's Hospital
2019
Abstract Acute myeloid leukemia (AML) with mutated NPM1 is a newly recognized separate entity in the revised 2016 WHO classification, and associated favorable prognosis. While previous studies have evaluated binary fashion, we recently demonstrated significant independent negative prognostic effect of high mutant allele burden (VAF) at diagnosis cohort de novo AML patients. Although importance minimal residual disease (MRD) monitoring ‐mutated has been well characterized, potential...
PURPOSE Therapy-related acute myeloid leukemias (t-AML) are a heterogenous group of aggressive neoplasms that arise following exposure to cytotoxic chemotherapy and/or ionizing radiation. Many therapy-related (t-MN) associated with distinct chromosomal aberrations TP53 alterations, but little is known about the clinicopathologic and molecular features normal karyotype t-AML (NK-t-AML) whether this t-MN subtype distinctly different from NK de novo AML (NK-dn-AML). METHODS This...
Abstract Multiparametric imaging allows researchers to measure the expression of many biomarkers simultaneously, allowing detailed characterization cell microenvironments. One such technique, CODEX, fluorescence >30 proteins in a single tissue section. In commercial CODEX system, primary antibodies are conjugated DNA barcodes. This modification can result antibody dysfunction, and development custom panel be very costly time consuming as trial error modified proceeds. To address these...
Acute leukemias of ambiguous lineage (ALAL) comprise acute undifferentiated (AUL) and mixed-phenotype (MPAL). In the revised fourth edition World Health Organization (WHO) classification provided further refinements to diagnostic criteria for ALAL. Molecular characterization MPALs using comprehensive next-generation sequencing (NGS) has insights into their underlying biology enabled a deeper understanding ALAL classification. This review addresses various components pathologic assessment...
The clinicopathologic features of DNA methyltransferase 3A (DNMT3A)-mutated de novo acute myeloid leukemia (AML), and the significance variant type, allele frequency (VAF), multiple concomitant DNMT3A mutations, remain poorly defined. We examined 104 DNMT3A-mutated AML patients from 2 major centers. Most (82%) had normal karyotype (NK); R882H variants were frequent(38%). most commonly comutated genes included nucleophosmin (NPM1; 53%), Fms-related tyrosine kinase 3 (FLT3)-internal tandem...
<title>Abstract</title> Somatic mutations in nucleophosmin (<italic>NPM1</italic>) are key defining a common subtype of acute myeloid leukemia (<italic>NPM1</italic>-AML), characterized by chromosomal stability and favorable therapeutic responses. However, some patients exhibit suboptimal response to initial treatment, relapses common, highlighting the need for novel biomarkers. Notably, <italic>NPM1</italic>and <italic>TP53</italic> rarely co-occur AML, where correlate with aneuploidy poor...
Jorge Monge receives consulting fees from Bristol Myers Squibb. Meri Razavi, Liming Bao, and Sanjay S. Patel have no conflicts of interest to disclose.
Abstract Multiparametric imaging allows researchers to measure the expression of many biomarkers simultaneously, allowing detailed characterization cell microenvironments. One such technique, CODEX, fluorescence >30 proteins in a single tissue section. In commercial CODEX system, primary antibodies are conjugated DNA barcodes. This modification can result antibody dysfunction, and development custom panel be very costly time consuming as trial error modified proceeds. To address these...
ABSTRACT The spatial anatomy of hematopoiesis in bone marrow has been extensively studied mice and other preclinical models, but technical challenges have precluded a commensurate exploration humans. Institutional pathology archives contain thousands paraffinized core biopsy tissue specimens, providing rich resource for studying the intact human topography variety physiologic states. Thus, we developed an end-to-end pipeline involving multiparameter whole staining, situ imaging at...