Alain Borczuk
A5002110784- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Occupational and environmental lung diseases
- Long-Term Effects of COVID-19
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 and COVID-19 Research
- Pleural and Pulmonary Diseases
- Microtubule and mitosis dynamics
- Metastasis and carcinoma case studies
- Cancer Research and Treatments
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Genetics, Aging, and Longevity in Model Organisms
- Pulmonary Hypertension Research and Treatments
- COVID-19 and healthcare impacts
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Respiratory Support and Mechanisms
- Neuroblastoma Research and Treatments
Weill Cornell Medicine
2016-2025
Cornell University
2016-2025
Northwell Health
2022-2024
Hofstra University
2023-2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2022-2024
Cardiovascular Institute Hospital
2024
Lenox Hill Hospital
2024
Footscray Hospital
2022-2023
RELX Group (United States)
2016-2023
Presbyterian Hospital
2016-2023
Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory that in ∼10-15% of patients progresses to acute distress syndrome (ARDS) triggered by cytokine storm. In this Perspective, autopsy results and literature are presented supporting the hypothesis little known yet powerful function neutrophils-the ability form neutrophil extracellular traps (NETs)-may contribute organ damage mortality COVID-19. We show lung infiltration neutrophils an specimen from patient who succumbed...
Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose.To provide updated practical guidelines for the pathologic diagnosis of MM.Pathologists involved in International Mesothelioma Interest Group and others with interest field contributed this update. Reference material includes peer-reviewed publications textbooks.There was consensus opinion regarding (1) distinction benign from malignant mesothelial proliferations (both epithelioid spindle cell lesions), (2)...
Pulmonary arterial hypertension is a devastating disease with high mortality. Familial cases of pulmonary are usually characterized by autosomal dominant transmission reduced penetrance, and some familial have unknown genetic causes.We studied family in which multiple members had without identifiable mutations any the genes known to be associated disease, including BMPR2, ALK1, ENG, SMAD9, CAV1. Three were whole-exome sequencing. Additional patients or idiopathic screened for gene that was...
Heritable and idiopathic pulmonary arterial hypertension (PAH) are phenotypically identical associated with mutations in several genes related to transforming growth factor (TGF) beta signaling, including bone morphogenetic protein receptor type 2, activin receptor-like kinase 1, endoglin, mothers against decapentaplegic 9. Approximately 25% of heritable cases lack identifiable any these genes.
To further understand the molecular pathogenesis of pulmonary sarcomatoid carcinoma (PSC) and develop new therapeutic strategies in this treatment-refractory disease.Whole-exome sequencing a discovery set (n = 10) as well targeted MET mutation screening an independent validation 26) PSC were performed. Reverse transcriptase polymerase chain reaction Western blotting performed to validate exon 14 skipping. Functional studies for oncogenic roles skipping conducted lung adenosquamous cell line...
Abstract Context.—Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. Objective.—To develop practical guidelines for the pathologic diagnosis of MM. Data Sources.—A pathology panel was convened at International Mesothelioma Interest Group biennial meeting (October 2006). Pathologists with interest in field also contributed after meeting. Conclusions.—There consensus opinion regarding (1) distinguishing benign from malignant mesothelial proliferations (both...
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying COVID biology, we compared short- and long-term systemic responses golden hamster after either SARS-CoV-2 influenza A virus (IAV) infection. Results demonstrated that exceeded IAV its capacity cause permanent injury lung kidney uniquely...
Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have achieved some clinical success, the inactivation kinase signaling via stimulation endogenous phosphatases has received minimal attention as an alternative targeted approach. Here, we demonstrated that activation tumor suppressor protein phosphatase 2A (PP2A), a negative regulator multiple proteins, is promising therapeutic approach...