A5036593455- Olfactory and Sensory Function Studies
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Chemical Sensor Technologies
- Invertebrate Immune Response Mechanisms
- COVID-19 Clinical Research Studies
- Phagocytosis and Immune Regulation
- Biochemical Analysis and Sensing Techniques
- Hippo pathway signaling and YAP/TAZ
- Photochromic and Fluorescence Chemistry
- IL-33, ST2, and ILC Pathways
- Neurobiology and Insect Physiology Research
- Silkworms and Sericulture Research
- Mosquito-borne diseases and control
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Viral Infections and Vectors
- Photoacoustic and Ultrasonic Imaging
Rockefeller University
2023-2025
Howard Hughes Medical Institute
2025
Columbia University
2020-2024
Brain (Germany)
2021
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying COVID biology, we compared short- and long-term systemic responses golden hamster after either SARS-CoV-2 influenza A virus (IAV) infection. Results demonstrated that exceeded IAV its capacity cause permanent injury lung kidney uniquely...
Abstract Olfactory receptor (OR) choice provides an extreme example of allelic competition for transcriptional dominance, where every olfactory neuron stably transcribes one approximately 2,000 or more OR alleles 1,2 . gene is mediated by a multichromosomal enhancer hub that activates transcription at single 3,4 , followed OR-translation-dependent feedback stabilizes this 5,6 Here, using single-cell genomics, we show formation many competing hubs with variable composition, only which retains...
Abstract Olfaction relies on a coordinated partnership between odorant flow and neuronal communication. Disruption in our ability to detect odors, or anosmia, has emerged as hallmark symptom of infection with SARS-CoV-2, yet the mechanism behind this abrupt sensory deficit remains elusive. Here, using molecular evaluation human olfactory epithelium (OE) from subjects succumbing COVID-19 hamster model SARS-CoV-2 infection, we discovered widespread downregulation receptors (ORs) well key...
SUMMARY SARS-CoV-2 has been found capable of inducing prolonged pathologies collectively referred to as Long-COVID. To better understand this biology, we compared the short- and long-term systemic responses in golden hamster following either or influenza A virus (IAV) infection. While exceeded IAV its capacity cause injury lung kidney, most significant changes were observed olfactory bulb (OB) epithelium (OE) where inflammation was visible beyond one month post Despite a lack detectable...
Despite the recent advances in understanding mechanisms of olfaction, no tools are currently available to noninvasively identify loss smell. Because substantial increase patients presenting with coronavirus disease 2019–related smell, pandemic has highlighted urgent need develop quantitative methods. <b>Methods:</b> Our group investigated use a novel fluorescent probe named Tsp1a-IR800<sub>P</sub> as tool diagnose targets sodium channel 1.7, which plays critical role olfaction by aiding...
The process of apoptosis in epithelia involves activation caspases, delamination cells, and degradation cellular components. Corpses debris are then rapidly cleared from the tissue by phagocytic blood cells. In studies Drosophila TNF, Eiger (Egr) cell death wing imaginal discs, epithelial primordia fly wings, we noticed that dying cells appeared to transiently accumulate egr3 mutant raising possibility their engulfment hemocytes was impaired. Further investigation revealed lymph glands...
Numerous factors have been implicated in the cell-cell interactions that lead to elimination of cells via cell competition, a context-dependent process selection somatic tissues is based on comparisons cellular fitness. Here, we use series genetic tests Drosophila explore relative contribution pleiotropic cytokine tumor necrosis factor α (TNFα) Myc-mediated competition (also known as Myc supercompetition or competition). We find sole TNF, Eiger (Egr), its receptor Grindelwald (Grnd/TNF...
The sense of smell (olfaction) is one the most important senses for animals including humans. Despite significant advances in understanding mechanism olfaction, currently, there are no objective non-invasive methods that can identify loss smell. Covid-19-related has highlighted need to develop olfaction. Voltage-gated sodium channel 1.7 (Na
Abstract The process of apoptosis in epithelia involves activation caspases, delamination cells, and degradation cellular components. Corpses debris are then rapidly cleared from the tissue by phagocytic blood cells. In studies Drosophila TNF, Eiger (Egr) cell death wing imaginal discs, epithelial primordia fly wings, we noticed that dying cells persisted longer egr 3 mutant discs than wild type raising possibility their engulfment hemocytes was impaired. Further investigation revealed lymph...
Abstract Numerous factors have been implicated in the cell-cell interactions that lead to elimination of cells via cell competition, a context-dependent process selection somatic tissues is based on comparisons cellular fitness. Here we use series genetic tests Drosophila explore relative contribution pleiotropic cytokine Tumor Necrosis Factor ⍺ (TNF⍺) Myc-mediated competition (also known as Myc super-competition or competition). We find sole TNF, Eiger (Egr), its receptor Grindelwald...
SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe damage a variety organs. Thus, deciphering non-cell autonomous effects infection is imperative for understanding cellular and molecular disruption elicits. Neurological cognitive defects are among least understood symptoms COVID-19 patients, with olfactory dysfunction being their most common sensory deficit. Here, we show that both humans hamsters causes widespread downregulation receptors (OR) signaling...