A5082738690- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- interferon and immune responses
- Peripheral Neuropathies and Disorders
- Virus-based gene therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- Pluripotent Stem Cells Research
- Biosensors and Analytical Detection
- Child Development and Digital Technology
- Neuroendocrine regulation and behavior
- Influenza Virus Research Studies
NYU Langone Health
2021-2023
New York University
2022-2023
Icahn School of Medicine at Mount Sinai
2021
Georgia State University
2019
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying COVID biology, we compared short- and long-term systemic responses golden hamster after either SARS-CoV-2 influenza A virus (IAV) infection. Results demonstrated that exceeded IAV its capacity cause permanent injury lung kidney uniquely...
Although largely confined to the airways, SARS-CoV-2 infection has been associated with sensory abnormalities that manifest in both acute and chronic phenotypes. To gain insight on molecular basis of these abnormalities, we used golden hamster model characterize compare effects influenza A virus (IAV) nervous system. We detected transcripts but no infectious material cervical thoracic spinal cord dorsal root ganglia (DRGs) within first 24 hours intranasal infection. SARS-CoV-2–infected...
Genetically engineered mouse models (GEMMs) help us to understand human pathologies and develop new therapies, yet faithfully recapitulating diseases in mice is challenging. Advances genomics have highlighted the importance of non-coding regulatory genome sequences, which control spatiotemporal gene expression patterns splicing many diseases1,2. Including extensive genomic regions, requires large-scale engineering, should enhance quality disease modelling. Existing methods set limits on size...
SUMMARY SARS-CoV-2 has been found capable of inducing prolonged pathologies collectively referred to as Long-COVID. To better understand this biology, we compared the short- and long-term systemic responses in golden hamster following either or influenza A virus (IAV) infection. While exceeded IAV its capacity cause injury lung kidney, most significant changes were observed olfactory bulb (OB) epithelium (OE) where inflammation was visible beyond one month post Despite a lack detectable...
Clinical presentations that develop in response to infection result from interactions between the pathogen and host defenses. SARS-CoV-2, etiologic agent of COVID-19, directly antagonizes these defenses, leading delayed immune engagement lungs materializes only as cells succumb are phagocytosed. Leveraging golden hamster model we sought understand dynamics SARS-CoV-2 airways systemic ensues. We found early replication was largely confined respiratory tract olfactory system and, a lesser...
Abstract Many neural sex differences are in the number of neurons a particular phenotype. For example, male rodents have more calbindin-expressing medial preoptic area (mPOA) and bed nucleus stria terminalis (BNST), females expressing estrogen receptor alpha (ERα) kisspeptin ventromedial hypothalamus (VMH) anteroventral periventricular (AVPV), respectively. These depend on neonatal exposure to testosterone, but underlying molecular mechanisms unknown. DNA methylation is important for cell...
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19) pandemic, drastically modifies infected cells to optimize virus replication. One such modification is activation host p38 mitogen-activated protein kinase (MAPK) pathway, which plays a major role in inflammatory cytokine production, hallmark severe COVID-19. We previously demonstrated that inhibition p38/MAPK activity SARS-CoV-2-infected reduced both production and viral...
Abstract SARS-CoV-2, the causative agent of COVID-19 pandemic, drastically modifies infected cells in an effort to optimize virus replication. Included is activation host p38 mitogen-activated protein kinase (MAPK) pathway, which plays a major role inflammation and central driver clinical presentations. Inhibition p38/MAPK activity SARS-CoV-2-infected reduces both cytokine production viral Here, we combined genetic screening with quantitative phosphoproteomics better understand interactions...
Despite being largely confined to the airways, SARS-CoV-2 infection has been associated with sensory abnormalities that manifest in both acute and long-lasting phenotypes. To gain insight on molecular basis of these abnormalities, we used golden hamster model characterize effects versus Influenza A virus (IAV) nervous system. Efforts detect presence cervical/thoracic spinal cord dorsal root ganglia (DRGs) demonstrated detectable levels by quantitative PCR RNAscope uniquely within first 24...
Abstract Genetically Engineered Mouse Models (GEMMs) aid in understanding human pathologies and developing new therapeutics, yet recapitulating diseases authentically mice is challenging to design execute. Advances genomics have highlighted the importance of non-coding regulatory genome sequences controlling spatiotemporal gene expression patterns splicing diseases. It thus apparent that including genomic regions during engineering GEMMs highly preferable for disease modeling, with...
SARS-CoV-2, the virus responsible for COVID-19 pandemic, has been found capable of inducing long term effects commonly referred to as post-acute sequelae SARS-CoV-2 (PASC) or COVID. To define molecular basis this condition, we compared short- and long-term responses influenza A SARSCoV-2 in golden hamster model. These data demonstrated that resulted sustained changes lung, kidney, brain. The most significant change response was observed olfactory bulb, where persistent inflammation visible...