A5070777856- Photodynamic Therapy Research Studies
- Head and Neck Cancer Studies
- PARP inhibition in cancer therapy
- Oral Health Pathology and Treatment
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Radiation Therapy and Dosimetry
- Advanced Biosensing Techniques and Applications
- Pain Mechanisms and Treatments
- Medical Imaging Techniques and Applications
- Neuropeptides and Animal Physiology
- Olfactory and Sensory Function Studies
- Esophageal Cancer Research and Treatment
- Concrete Corrosion and Durability
- bioluminescence and chemiluminescence research
- Advanced Chemical Sensor Technologies
- Colorectal and Anal Carcinomas
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Molecular Communication and Nanonetworks
- Proteoglycans and glycosaminoglycans research
- Neuroscience and Neural Engineering
- Thyroid and Parathyroid Surgery
Memorial Sloan Kettering Cancer Center
2018-2024
Universidade Federal de São Paulo
2014-2024
Zhuhai People's Hospital
2019
University of Colorado Anschutz Medical Campus
2019
Merck & Co., Inc., Rahway, NJ, USA (United States)
2019
Beneficência Portuguesa de São Paulo
2017
Abstract Purpose: Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent decades. Experimental Design: 123I-MAPi (Iodine-123 Meitner-Auger PARP1 inhibitor) precise therapeutic tool composed inhibitor radiolabeled an Auger- gamma-emitting iodine isotope. Here, the PARP inhibitor, which binds DNA repair enzyme PARP1,...
Abstract Purpose: We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility PET imaging with 18F-PARPi in patients head neck cancer. Patients Methods: Eleven newly diagnosed or recurrent oral oropharyngeal cancer were injected (331 ± 42 MBq), dynamic PET/CT between 0 25 minutes postinjection. Static scans obtained at 30, 60, 120 Blood samples for tracer concentration metabolite analysis collected. pressure, ECG, oxygen levels, chemistry,...
We report preclinical and first-in-human-brain-cancer data using a targeted poly (ADP-ribose) polymerase 1 (PARP1) binding PET tracer, [18F]PARPi, as diagnostic tool to differentiate between brain cancers treatment-related changes.We applied glioma model in p53-deficient nestin/tv-a mice, which were injected with [18F]PARPi then sacrificed h post-injection for examination. also prospectively enrolled patients undergo dynamic acquisition on dedicated positron emission tomography/magnetic...
Despite the recent advances in understanding mechanisms of olfaction, no tools are currently available to noninvasively identify loss smell. Because substantial increase patients presenting with coronavirus disease 2019–related smell, pandemic has highlighted urgent need develop quantitative methods. <b>Methods:</b> Our group investigated use a novel fluorescent probe named Tsp1a-IR800<sub>P</sub> as tool diagnose targets sodium channel 1.7, which plays critical role olfaction by aiding...
Twenty million Americans suffer from peripheral nerve injury caused by trauma and medical disorders, resulting in a broad spectrum of potentially debilitating side effects. In one out four cases, patients identify surgery as the root cause their injury. Particularly during tumor resections or after traumatic injuries, tissue distortion poor visibility can challenge surgeon's ability to precisely locate preserve nerves. Intuitively, surgical outcomes would improve tremendously if nerves could...
We report an innovative approach to producing bacteriochlorins (bacs) via formal cycloaddition by subjecting a porphyrin trimolecular reaction. Bacs are near-infrared probes with the intrinsic ability serve in multimodal imaging. However, despite their fluoresce and chelate metal ions, existing bacs have thus offered limited label biomolecules for target specificity or lacked chemical purity, limiting use bio-imaging. In this work, allowed precise controlled appending of clickable linkers,...
The human nociceptor-specific voltage-gated sodium channel 1.7 (hNaV1.7) is critical for sensing various types of somatic pain, but it appears not to play a primary role in acute visceral pain. However, its chronic pain remains be determined. We used assay-guided fractionation isolate novel hNaV1.7 inhibitor, Tsp1a, from tarantula venom. Tsp1a 28-residue peptide that potently inhibits (IC50 = 10 nM), with greater than 100-fold selectivity over hNaV1.3-hNaV1.6, 45-fold hNaV1.1, and 24-fold...
Surgeries and trauma result in traumatic iatrogenic nerve damage that can a debilitating condition approximately affects 189 million individuals worldwide. The risk of injury during oncologic surgery is increased due to tumors displacing normal location, blood turbidity, past surgical procedures, which complicate even an experienced surgeon's ability precisely locate vital nerves. Unfortunately, there glaring absence contrast agents assist surgeons safeguarding To address this unmet clinical...
Abstract Complete removal and negative margins are the goal of any surgical resection primary oral cavity carcinoma. Current approaches to determine tumor boundaries rely heavily on surgeons’ expertise, final histopathological reports usually only available days after surgery, precluding contemporaneous re-assessment positive margins. Intraoperative optical imaging could address this unmet clinical need. Using mouse models carcinoma, we demonstrated that PARPi-FL, a fluorescent PARP...
Accidental peripheral nerve injury during surgical intervention results in a broad spectrum of potentially debilitating side effects. Tissue distortion and poor visibility can significantly increase the risk with long-lasting consequences for patient. We developed characterized Hs1a-FL, fluorescent near-infrared molecule visualization operating theater aim helping physicians to visualize nerves surgery. Hs1a was derived from venom Chinese bird spider, Haplopelma schmidti, conjugated Cy7.5...
Introduction Scanned fibre endomicroscopes are full point-scanning confocal microscopes with submicron lateral resolution an optical slice thickness thin enough to isolate individual cell layers, allow active positioning of the in z-axis and collection megapixel images. Here we present descriptive findings a brief atlas acquisition annotation protocol high vivo capture oral mucosal pathology including squamous carcinoma dysplasia using fluorescence scanned endomicroscope 3 topical...
We investigated reflectance confocal microscopy (RCM) as a possible noninvasive approach for the diagnosis of cancer and real-time assessment surgical margins.
Abstract Major determining factors for survival of patients with oral, oropharyngeal, and esophageal cancer are early detection, the quality surgical margins, contemporaneous detection residual tumor. Intuitively, exposed location at epithelial surface qualifies these tumor types utilization visual aids to assist in discriminating from healthy surrounding tissue. Here, we explored DNA repair enzyme PARP1 as imaging biomarker conducted optical animal models, human tissues part a...
Despite efforts in prevention, cervical cancer still presents with a high worldwide incidence and remains great problem public health, especially low-income countries. Screening programs, such as colposcopy Papanicolaou testing, have greatly improved mortality rates. However, the agents currently used to delineate those lesions (topical application of acetic acid or Lugol iodine) lack specificity sometimes can lead unnecessary biopsies even excisions. A tool enable in vivo histology...
Almost 17 million Americans have a history of cancer, number expected to reach over 22 by 2030. Cancer patients often undergo chemotherapy in the form antineoplastic agents such as cis-platin and paclitaxel. Though effective, these can induce debilitating side effects; most common neurotoxic effect, chemotherapy-induced peripheral neuropathy (CIPN), endure long after treatment ends. Despite widespread chronic nature dysfunction, no tools exist quantitatively measure neuropathy. Such tool...
Abstract We report pre-clinical and first-in-human-brain-cancer data using a targeted poly(ADP-ribose)polymerase1 (PARP1) binding PET tracer, [ 18 F]PARPi, as diagnostic tool to differentiate between brain cancers treatment related changes. In mouse model, we illustrated that F]PARPi crosses the blood-brain barrier specifically binds PARP1 overexpressed in cancer cell nuclei. humans, demonstrated high uptake on PET/MR active low changes, independent of blood brain-barrier disruption....
Abstract Glioblastoma multiforme is a highly aggressive form of brain cancer whose location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit survival, with scant progress having been made in recent decades. 123 I-MAPi (Iodine-123 Meitner-Auger PARP1 inhibitor) precise therapeutic tool composed inhibitor radiolabeled an Auger- gamma-emitting iodine isotope. Here, the PARP inhibitor, which binds DNA repair enzyme PARP1, specifically targets cells,...
Abstract Purpose We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility PET imaging with 18 F-PARPi in patients head neck cancer. Patients Methods Eleven (age 49 86 years) newly diagnosed or recurrent oral oropharyngeal cancer were injected intravenously (331 ± 42 MBq) dynamic PET/CT between 0 min 25 post-injection. Static scans obtained at 30 min, 60 120 p.i. Blood samples for tracer concentration metabolite analysis collected. pressure,...