A5026131694- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Head and Neck Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- PARP inhibition in cancer therapy
- Acute Lymphoblastic Leukemia research
- Neuroendocrine Tumor Research Advances
- Bioinformatics and Genomic Networks
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Cytomegalovirus and herpesvirus research
- Lung Cancer Research Studies
- Acute Myeloid Leukemia Research
- Cancer therapeutics and mechanisms
- Statistical Methods in Clinical Trials
Memorial Sloan Kettering Cancer Center
2016-2025
Cancer Research And Biostatistics
2020-2025
Weill Cornell Medicine
2024
Cornell University
2024
Kettering University
2022
Inserm
2010-2017
Bordeaux Population Health
2013-2017
Université de Bordeaux
2013-2017
Institut Gustave Roussy
2008-2016
La Ligue Contre le Cancer
2016
COVID-19 in Children With Cancer New York CityData on the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection children, [1][2][3][4] and children with cancer specifically have been limited.Less than 1% cases reported from China were younger 10 years. 3 The MSK Kids pediatric program at Memorial Sloan Kettering Center (MSK) is one largest programs US.Starting mid-March, 2020, we instituted a screening testing plan to mitigate risk associated disease 2019 (COVID-19).
Purpose The impact of adding vinblastine to a 4-month chemotherapy regimen, based on the Non-Hodgkin's Lymphoma Berlin-Frankfurt-Münster 90 protocol, in childhood high-risk anaplastic large-cell lymphoma (ALCL) was assessed. Patients and Methods Children adolescents with ALCL, defined by mediastinal, lung, liver, spleen, or skin involvement, were eligible for trial. After prephase one course, patients randomly assigned receive either five further courses without same regimen injection (6...
The prognostic value of pathologic characteristics childhood ALK-positive anaplastic large-cell lymphomas (ALCL), such as histologic subtypes, immunophenotype, and presence the t(2;5) translocation or its variants, was assessed.All 375 patients with systemic ALCL included in an international trial launched by European Intergroup for Childhood Non-Hodgkin's Lymphoma were reviewed panel pathologists based on conventional hematoxylin eosin-stained immunostained sections classified according to...
The high incidence of recurrence and unpredictable clinical outcome for pediatric ependymoma reflect the imprecision current therapeutic staging need novel risk stratification markers. We therefore evaluated 1q25 gain across three age- treatment-defined European trial cohorts intracranial ependymoma.Frequency 1q was assessed 48 ependymomas (42 primary, 6 recurrent) using Affymetrix 500K single-nucleotide polymorphism arrays. Gain then by interphase FISH 189 tumors treated on Children's...
Invasive lobular carcinoma (ILC) demonstrates lower conspicuity on <sup>18</sup>F-FDG PET than the more common invasive ductal carcinoma. Other molecular imaging methods may be needed for evaluation of this malignancy. As ILC is nearly always (95%) estrogen receptor (ER)–positive, ER-targeting tracers such as 16α-<sup>18</sup>F-fluoroestradiol (<sup>18</sup>F-FES) have value. We reviewed prospective trials at Memorial Sloan Kettering Cancer Center using <sup>18</sup>F-FES PET/CT to evaluate...
Anti-GD2 monoclonal antibody (mAb) has proven efficacy in high-risk neuroblastoma (HR-NB). A small phase I GD2/GD3 vaccine trial (n = 15) described long-term survival and a favorable safety profile among patients with history of disease progression (PD). The kinetics mounting response to its prognostic impact on are now investigated II study (ClinicalTrials.gov identifier: NCT00911560).One hundred two HR-NB who achieved remission after salvage therapies were enrolled this trial. They...
Chimeric antigen receptor (CAR) T cells provide a therapeutic option in hematologic malignancies. However, treatment failure after initial response approaches 50%. In allogeneic hematopoietic cell transplantation, optimal fludarabine exposure improves immune reconstitution, resulting lower nonrelapse mortality and increased survival. We hypothesized that lymphodepleting chemotherapy before CAR T-cell therapy would improve outcomes. retrospective analysis of patients with relapsed/refractory...
Abstract Background Safe sampling of central nervous system tumor tissue for diagnostic purposes may be difficult if not impossible, especially in pediatric patients, and an unmet need exists to develop less invasive tests. Methods We report our clinical experience with minimally molecular diagnostics using a clinically validated assay sequencing cerebrospinal fluid (CSF) cell-free DNA (cfDNA). All CSF samples were collected as part care, results reported both clinicians patients/families....
BACKGROUND. Refractory CMV viremia and disease are associated with significant morbidity mortality in recipients of hematopoietic stem cell transplant (HCT).
Abstract Predicting in vivo response to antineoplastics remains an elusive challenge. We performed a first-of-kind evaluation of two transcriptome-based precision cancer medicine methodologies predict tumor sensitivity comprehensive repertoire clinically relevant oncology drugs, whose mechanism action we experimentally assessed cognate cell lines. enrolled patients with histologically distinct, poor-prognosis malignancies who had progressed on multiple therapies, and developed low-passage,...
Radioimmunoconjugates targeting human epidermal growth factor receptor 2 (HER2) have shown potential to noninvasively visualize HER2-positive tumors. However, the stochastic approach that has been traditionally used radiolabel these antibodies yields poorly defined and heterogeneous products with suboptimal in vivo performance. Here, we describe a first-in-human PET study on patients breast cancer evaluating safety, biodistribution, dosimetry of <sup>89</sup>Zr-site-specific...
Importance There are insufficient data comparing 16α- 18 F-fluoro-17β-estradiol (FES) positron emission tomography (PET) computed (CT) with standard-of-care imaging (SOC) for staging locally advanced breast cancer (LABC) or evaluating suspected recurrence. Objective To determine the detection rate of FES PET/CT and SOC distant metastases in patients estrogen receptor (ER)-positive LABC recurrences ER-positive BC Design, Setting, Participants This diagnostic study was conducted as a...
The aim of this study was to evaluate the prognostic factors and morbidities patients undergoing completion surgery for locally advanced-stage cervical cancer after initial chemoradiation therapy (CRT).Patients fulfilling following inclusion criteria were studied: stage IB2-IVA carcinoma, tumor initially confined pelvic cavity on conventional imaging, external radiation with delivery 45 Gy concomitant chemotherapy (cisplatin, 40 mg/m(2) per week) followed by uterovaginal brachytherapy, end...
Abstract Purpose: We performed a first-in-human clinical trial. The aim of this study was to determine safety and feasibility PET imaging with 18F-PARPi in patients head neck cancer. Patients Methods: Eleven newly diagnosed or recurrent oral oropharyngeal cancer were injected (331 ± 42 MBq), dynamic PET/CT between 0 25 minutes postinjection. Static scans obtained at 30, 60, 120 Blood samples for tracer concentration metabolite analysis collected. pressure, ECG, oxygen levels, chemistry,...
The prognosis for patients with pediatric high-grade glioma (pHGG) is poor despite aggressive multimodal therapy. Objective responses to targeted therapy BRAF inhibitors have been reported in some recurrent BRAF-mutant pHGG but are rarely sustained.
Abstract Resistance mechanisms and heterogeneity in HER2-positive gastric cancers (GC) limit Trastuzumab benefit 32% of patients, other targeted therapies have failed clinical trials. Using patient samples, patient-derived xenografts (PDXs), partially humanized biological models, HER2-targeted imaging technologies we demonstrate the role caveolin-1 (CAV1) as a complementary biomarker GC selection for therapy. In retrospective analyses samples from patients enrolled on trials, CAV1-high...
In the premature infant, somatosensory and visual stimuli trigger an immature electroencephalographic (EEG) pattern, "delta-brushes," in corresponding sensory cortical areas. Whether auditory evoke delta-brushes cortex has not been reported. Here, responses to were studied 46 infants without neurologic risk aged 31 38 postmenstrual weeks (PMW) during routine EEG recording. Stimuli consisted of either low-volume technogenic "clicks" near background noise level neonatal care unit, or a human...