A5083044084- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Congenital Anomalies and Fetal Surgery
- Ultrasound in Clinical Applications
- Health, Medicine and Society
- Atomic and Subatomic Physics Research
- Palliative Care and End-of-Life Issues
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Neonatal Health and Biochemistry
- Infant Development and Preterm Care
- Thyroid Disorders and Treatments
- Hernia repair and management
- Central Venous Catheters and Hemodialysis
- Foreign Body Medical Cases
- Neonatal and Maternal Infections
- Congenital Heart Disease Studies
- Neural dynamics and brain function
- Pediatric Pain Management Techniques
- Aging, Elder Care, and Social Issues
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Pleural and Pulmonary Diseases
- Family and Patient Care in Intensive Care Units
Assistance Publique – Hôpitaux de Paris
2012-2024
Bicêtre Hospital
2012-2024
Université Paris-Saclay
2021-2024
Hôpitaux Universitaires Paris-Ouest
2020-2023
University of Tehran
2011-2021
Hudson Institute
2018
Université Paris-Sud
2012-2018
John Wiley & Sons (United Kingdom)
2018
Université Paris Cité
2014
Hôpital Saint-Vincent-de-Paul
1993-2013
In the premature infant, somatosensory and visual stimuli trigger an immature electroencephalographic (EEG) pattern, "delta-brushes," in corresponding sensory cortical areas. Whether auditory evoke delta-brushes cortex has not been reported. Here, responses to were studied 46 infants without neurologic risk aged 31 38 postmenstrual weeks (PMW) during routine EEG recording. Stimuli consisted of either low-volume technogenic "clicks" near background noise level neonatal care unit, or a human...
Objectives: Central venous access in critically ill, small infants remains technically challenging even experienced hands. Several vascular accesses exist, but the subclavian vein is often preferred for central catheter insertion where abdominal malformation and/or closure of preclude use umbilical catheters, as catheterization easier very short necks than internal jugular age-related anatomical reasons. The approach yet relatively undescribed low birth weight (i.e., < 2,500 g), and this...
Enterobacter cloacae complex contains nosocomial pathogens responsible for infection outbreaks. Identification at the species level within E remains difficult. Using whole genome sequencing, our aim was to decipher transmission routes that led death of six seven neonates who had bacteraemia caused by isolates in a neonatal intensive care unit (NICU) over 13 month period.In this cohort study, were taken from 186 newborns an NICU: 14 clinical samples (eg, blood cultures), 728 rectal swab...
Neonatal hyperthyroidism was first described in 1912 and 1964 shown to be linked transplacental passage of maternal antibodies. Few multicenter studies have the perinatal factors leading fetal neonatal dysthyroidism. To show how dysthyroidism (FD) (ND) can predicted from variables, particular, levels anti-thyrotropin receptor antibodies (TRAbs) circulating mother child. This a retrospective study data medical records all patients monitored for pregnancy 2007 2014. Among 280,000 births, 2288...
Characteristic preterm EEG patterns of "Delta-brushes" (DBs) have been reported in the temporal cortex following auditory stimuli, but their spatio-temporal dynamics remains elusive. Using 32-electrode recordings and co-registration electrodes' position to 3D-MRI age-matched neonates, we explored cortical auditory-evoked responses (AERs) after 'click' stimuli 30 healthy neonates aged 30-38 post-menstrual weeks (PMW). (1) We visually identified DBs within AERs all babies between 33 PMW a...
Background and Objective Congenital pulmonary airway malformation (CPAM) is a group of rare congenital malformations the lung airways. Lung ultrasound (LU) increasingly used to diagnose neonatal respiratory diseases since it quick, easy learn, radiation-free, but no formal data exist for malformations. We aimed describe LU findings in CPAM neonates needing intensive care unit (NICU) admission compare them with control population. Methods A retrospective review cases from three tertiary...
Abstract Objective To evaluate neonatal mortality and morbidity up to 6 months in neonates with congenital diaphragmatic hernia (CDH) or without a sac. Methods Seventy‐two cases of isolated CDH were included retrospective single‐center study between January 2010 December 2016. Hernia sac was defined at the time surgery postmortem examination if neonate died before surgery. Results Seventeen newborns (23.6%) had Survival significantly greater for sac: 100% versus 63.6% ( P = .003)....
Rationale Congenital diaphragmatic hernia (CDH) is associated with a high incidence of respiratory problems, even after initial hospital discharge. These problems are likely to lead re-hospitalization during infancy, although actual frequency readmissions unknown. Objective We aimed determine the rate hospitalization for wheezing in infants CDH between time discharge and 24 months age, identify factors readmission. Methods Data about born three French reference tertiary centers January 2009...
Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly and remains among the most challenging ICU-managed disease. Beside severe pulmonary hypertension, lung hypoplasia major abdominal surgery, infective complications remain determinants of outcome. However, specific incidence sepsis as well associated risk factors unknown. This prospective, 4-year observational study took place in pediatric intensive care neonatal medicine department Paris South University Hospitals (Le...
BACKGROUND Red blood cell (RBC) Thomsen‐Friedenreich antigen exposure (T activation) in infants with necrotizing enterocolitis (NEC) has occasionally been associated posttransfusional intravascular hemolysis thought to be due anti‐T antibodies the donor plasma. STUDY DESIGN AND METHODS We describe an infant NEC and Clostridium perfringens infection complicated by severe after plasma transfusion. After this case, confirmed were prospectively evaluated for T activation. checked patients...
Objectives: To evaluate the positive threshold of PCT for neonates &lt;32 weeks gestation diagnosis early-onset sepsis and to determine if level collected within 6 h life could be used. Design: Retrospective bicentric study from May 2016 April 2018. Setting: Two groups were established, evaluated at birth (CordPCT) (delPCT). Patients: hundred sixty born in Nice South Paris (Bicêtre) University Hospitals, had been level. Main Outcomes Measures: The value was determined total population...
During the third trimester of gestation in human, auditory cortex displays spontaneous and evoked EEG pattern intermittent local oscillatory activity nested delta wave - Delta-brushes (DBs). To test if DBs display discrimination, we explored spatiotemporal dynamics responses (AERs) to voice “click” using 32-electrodes thirty healthy neonates aged 30 38 post-menstrual weeks. Both stimuli elicited two peaks at around 250 ms 600 corresponding principal components (PC) AERs. PC1 (evoked DB)...
Objective To study the pharmacokinetics of flunitrazepam (used for sedation in neonates and infants), to determine influence both gestational postnatal age on pharmacokinetic parameters, analyze relationship between hemodynamic parameters plasma concentration. Methods Flunitrazepam was infused 20 minutes as a single dose (0.2 mg · kg−1) multiple doses (0.1 kg−1). Six eight 1-mL blood samples were collected per patient. concentration measured by gas chromatography–mass spectrometry. Results...
Umbilical Venous Catheter (UVC) and Epicutaneo-Caval Catheters (ECC) are reference catheters in the neonatal period. However, many factors such as corpulence of neonates, poor venous capital, anatomical variants can complicate ECC insertion or make it impossible. In newborns with failed insertion, we developed an hybrid technique that combines a long-lasting silicone polyurethane small caliber catheter, usually used newborns, ease speed ultrasound guided puncture brachiocephalic vein...