A5018849810- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Health, Medicine and Society
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- COVID-19 and Mental Health
- Social Policies and Family
- Central Venous Catheters and Hemodialysis
- Hemodynamic Monitoring and Therapy
- Congenital Heart Disease Studies
- Death, Funerary Practices, and Mourning
- Historical and Scientific Studies
- Infective Endocarditis Diagnosis and Management
- Corporate Insolvency and Governance
- Kawasaki Disease and Coronary Complications
- Epilepsy research and treatment
- Innovations in Medical Education
- Family and Patient Care in Intensive Care Units
- COVID-19 and healthcare impacts
- Tryptophan and brain disorders
- Vascular Malformations Diagnosis and Treatment
- Thermal Regulation in Medicine
Université Paris-Saclay
2019-2025
Bicêtre Hospital
2016-2025
Assistance Publique – Hôpitaux de Paris
2010-2025
Inserm
2016-2023
Centre National de la Recherche Scientifique
2021-2023
CEA Paris-Saclay
2021-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2021-2023
Institut de Biologie Intégrative de la Cellule
2021-2023
Université Paris Cité
2010-2023
Centre d’Investigation Clinique 1436
2022
Little is known about long-term sequelae of COVID-19.
Definitions for pediatric sepsis were established in 2005 without data-driven criteria. It is unknown whether the more recent adult Sepsis-3 definitions meet needs of providers caring children. We aimed to explore use and applicability criteria diagnose septic shock children across world.This an international electronic survey clinicians distributed national societies representing intensive care, emergency medicine, pediatrics, infectious diseases. Respondents stated their preferences on a...
Long COVID is a major public health issue. Whether long comorbid with psychiatric disorders remains unclear. Here, we investigate the association between COVID, symptoms and disorders.
Background: Transcatheter techniques are emerging for left atrial (LA) decompression under venoarterial extracorporeal membrane oxygenation (VA-ECMO). We aimed to assess whether balloon atrioseptostomy (BAS) is a safe and efficient strategy. Methods: All patients who underwent percutaneous static BAS VA-ECMO at four tertiary institutions were retrospectively reviewed. Results: From 2000 2014, was performed in 64 (32 adults 32 children). Indications ECMO support included acute myocarditis...
Importance Important advances have been made in extracorporeal blood purification therapies (EBPTs) due to new technologies and biomaterials; however, the lack of established guidelines is a factor great variability clinical practice. This aspect accentuated pediatric intensive care given small number patients with diverse diagnoses treated EBPT technical challenges treating children, potentiating risk adverse events. Objective To understand what experienced users think about its relevant...
Dyspnoea is a common persistent symptom after COVID-19. Whether it associated with functional respiratory disorders remains unclear.We assessed the proportion and characteristics of patients "functional complaints" (FRCs) (as defined by Nijmegen Questionnaire >22) among 177 post-COVID-19 individuals who benefited from outclinic evaluation in COMEBAC study (i.e., symptomatic and/or intensive care unit (ICU) survivors at 4 months). In distinct explanatory cohort 21 consecutive unexplained...
The characteristics of patients with respiratory complaints and/or lung radiologic abnormalities after hospitalisation for coronavirus disease 2019 (COVID-19) are unknown. objectives were to determine their and the relationships between dyspnoea, functional impairment.
We report a Bacillus cereus , cereulide producing strain, food poisoning of two sisters. After eating few bites pasta cooked 3 days earlier, 13-year-old girl developed mild symptoms. However, her 11-year-old sister suffered, 40 h after ingestion the entire platter, multi-organ failure including acute liver failure, rhabdomyolysis, disseminated intravascular coagulation, and kidney injury (AKI). She received supportive care in pediatric intensive using mechanical ventilation, hemofiltration,...
Abstract Background Acute fulminant myocarditis in children is associated with elevated mortality and morbidity few advances its medical management. Here we report a preliminary experience of treated IL-1 receptor antagonist rapid myocardial function recovery. Methods A retrospective case series admitted the Pediatric Intensive Care Unit Bicêtre Hospital (AP–HP Paris Saclay University) between April 2020 January 2022 acute myocarditis. Children were subcutaneous anakinra (an antagonist)....
Abstract Study objective In prehospital and emergency settings, vasoactive medications may need to be started through a peripheral intravenous catheter. Fear of extravasation skin injury, with norepinephrine specifically, prevent or delay vasopressor initiation, though studies from adults suggest the actual risk is low. We sought study injury administration in children setting. Methods performed retrospective pediatric patients (≤18 years) who received during transport. collected data...
The severity of SARS-CoV-2-related diseases in children remains unclear. This study aimed to describe the incidence French pediatric intensive care units (PICUs) admissions with acute COVID-19, incidental positive SARS-CoV-2 test result, and multisystem inflammatory syndrome (MIS-C) during delta omicron variant periods.This used PICU registry obtain data on all patients admitted 41 PICUs diagnosed or MIS-C between August 30, 2021 April 20, 2022. Data regarding total number polymerase chain...
De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring the concept of sepsis-associated immunological dysregulation, seems be a strong signature COVID-19. Myeloid cells phenotyping is well recognized diagnose critical illness-induced immunodepression in sepsis and has not been characterized The aim this study review phenotypic characteristics myeloid evaluate their relations with occurrence secondary infection mortality patients COVID-19 admitted an...
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. As such, circulating cytokines and danger- pathogen-associated molecular patterns (such as endotoxins) are recognized central in the pathogenesis of sepsis dysfunction. Removing these compounds extracorporeal blood filtration, commonly considered purification, may improve septic patients' condition. This study aimed assess vaso-inotropic support evolution over time pediatric patients with...
Acute bronchiolitis, a viral seasonal infection of the lower respiratory tract, affects nearly 20% all children and leads to hospitalization 2% 3% younger than 12 months every year.1,2 Approximately 6% hospitalized require admission PICU.1 bronchiolitis may account for as much 13% PICU admissions,3 it is responsible death ∼3 100 000 under each year4 (eg, 20 infants annually in England4 United States,5 respectively). Bronchiolitis epidemic has predictable pattern, France, starts September,...
The Surviving Sepsis Campaign and the American College of Critical Care Medicine guidelines have provided recommendations for management pediatric septic shock patients. We conducted a survey among European Society Pediatric Neonatal Intensive (ESPNIC) members to assess variations these recommendations. A total 114 intensive care physicians completed an electronic survey. consisted four standardized clinical cases exploring seven scenarios. Among different scenarios, types fluids were...
DiscussionIn this sample of survivors after hospitalization for acute COVID-19, we failed to show any association between COVID-19 objective severity and psychiatric disorders 4 months later.This result is in line with findings from 2 previous studies 4,5 focusing on anxiety depressive symptoms 6 weeks 200 81 patients, respectively.Similarly, a recent report 5 58 patients found no CRP during 3 later.Accordingly, study 75 showed mechanical ventilation discharge.However, the absence discharge...
Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy sequential organs scoring systems in admitted Paediatric Intensive Care Units (PICU).We performed a multicentre retrospective analysis into four European PICUs between 2011 and 2016. Investigators were members ESPNIC liver failure support working group. End-Stage Liver Disease (PELD) paediatric chronic organ assessment score (pCLIF-SOFA) diagnostic for 28- 60-day...