A5001276590- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nitric Oxide and Endothelin Effects
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Cardiac Structural Anomalies and Repair
- Anesthesia and Sedative Agents
- Restraint-Related Deaths
- Transplantation: Methods and Outcomes
- Respiratory viral infections research
- Adenosine and Purinergic Signaling
- Congenital Diaphragmatic Hernia Studies
- Metabolism and Genetic Disorders
- Congenital Heart Disease Studies
- Cellular transport and secretion
- Genetics and Neurodevelopmental Disorders
Sorbonne Université
2015-2024
Hôpital Armand-Trousseau
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Inserm
2012-2024
Université Paris 1 Panthéon-Sorbonne
2022-2024
Université Paris-Est Créteil
2021-2024
École Nationale Vétérinaire d'Alfort
2020-2024
Institut Mondor de Recherche Biomédicale
2020-2021
Agence Nationale des Fréquences
2021
Hôpital Robert-Debré
2009-2020
Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular protective pathways may provide therapeutic targets neurological disorders. S1P (Sphingosine 1-phosphate) signaling coordinates functions in other organs, 1 (S1P receptor-1) modulators including fingolimod show promise the treatment of ischemic hemorrhagic stroke. However, also lymphocyte trafficking, lymphocytes are currently viewed as principal target modulation Objective: To address roles mechanisms...
<h3>Objective</h3> With the largest data set of patients with<i>LIS1</i>-related lissencephaly, major cause posteriorly predominant lissencephaly related to either<i>LIS1</i>mutation or intragenic deletion, described so far, we aimed refine spectrum neurological and radiological features assess relationships with genotype. <h3>Design</h3> Retrospective study. <h3>Subjects</h3> A total 63 lissencephaly. <h3>Interventions</h3> Of patients, 40 were found carry either<i>LIS1</i>point mutations...
We recently demonstrated that endogenous nitric oxide (NO) modulates collateral blood flow in a neonatal stroke model rats. The inhalation of NO (iNO) has been found to be neuroprotective after ischemic brain damage adults. Our objective was examine whether iNO could modify cerebral during ischemia-reperfusion and reduce lesions the developing brain.In vivo variations cortical concentrations occurring 20-ppm exposure were analyzed using voltammetric method P7 rat pups. Inhaled NO-mediated...
Background and Purpose— The best conceivable treatment for hypoxia-ischemia (HI) is the restoration of blood flow to hypoxic-ischemic region(s). Our objective was examine whether boosting NO-cGMP signaling using sildenafil citrate, a phosphodiesterase-type 5 inhibitor, could modify cerebral reduce lesions in developing brain. Methods— HI induced P7 Sprague–Dawley rats by unilateral carotid artery occlusion hypoxia, followed either PBS or sildenafil. Blood-flow velocities were measured...
Perinatal ischemic stroke is the most frequent form of cerebral infarction in neonates; however, evidence-based treatments are currently lacking. We have previously demonstrated a beneficial effect sildenafil citrate, PDE-5 inhibitor, on lesion size neonatal rat pups. The present study investigated effects mouse model (1) hemodynamic changes and (2) regulation astrocyte/microglia-mediated neuroinflammation.Ischemia was induced C57Bl/6 mice postnatal (P) day 9 by permanent middle artery...
OBJECTIVES: Extracorporeal life support can lead to rapid reversal of hypoxemia but the benefits and harms different oxygenation targets in severely ill patients are unclear. Our primary objective was investigate association between Pa o 2 after extracorporeal membrane (ECMO) initiation mortality neonates treated for respiratory failure. DESIGN: Retrospective analysis Life Support Organization (ELSO) Registry data, 2015–2020. PATIENTS: Newborns supported by ECMO indication were included....
Spatial synthesis of N-acyl-phosphati-dylethanolamines (NAPEs) and N-acylethanolamines (NAEs) during ischemia-reperfusion in neonatal rats has been investigated compared to the spatial degradation other phospholipids. Ischemia was induced anesthetized Wistar P7 rat pups by left middle cerebral artery electrocoagulation combined with a transient concomitant occlusion both common carotid arteries. Pups were sacrificed after 24 48 h. Sham-treated animals The frozen brains sliced subjected...
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Objectives Extracorporeal membrane oxygenation support is indicated in severe and refractory respiratory or circulatory failures. Neurological complications are typically represented by acute ischemic hemorrhagic lesions, which induce higher morbidity mortality. The primary goal of this study was to assess the prognostic value cerebral tissue oxygen saturation (StcO2) on mortality neonates young infants treated with ECMO. A secondary objective evaluate association between StcO2 occurrence...
This study determined the influence of COVID-19 pandemic on occurrence multisystem inflammatory syndrome in children (MIS-C) and compared main characteristics MIS-C Kawasaki disease (KD).We included patients aged up to 18 years age who were diagnosed with or KD a paediatric university hospital Paris from 1 January 2018 15 July 2020. Clinical, laboratory imaging compared, new French cases correlated our hospital.There seven MIS-C, 6 months 12 age, all positive for virus that causes COVID-19,...
PCR-based methods applied to various body fluids emerged in recent years as a promising approach for the diagnosis of mucormycosis. In this study, we set up and assess value qPCR detect wide variety Mucorales species single tube. A pair degenerated primers targeting rDNA operon was used utilizing an intercalating fluorescent dye. Analytical assessment, using both strains (8 genera, 11 species) non-Mucorales (9 14 species), showed 100% sensitivity specificity rates with limit detection at 3...
The primary objective was to investigate the association between partial pressure of carbon dioxide (PaCO 2 ) change after extracorporeal membrane oxygenation (ECMO) initiation and neurologic outcome in neonates treated for respiratory failure. A retrospective analysis Extracorporeal Life Support Organization (ELSO) database including newborns supported by ECMO indication during 2015–2020. closest Pre-ECMO (Pre-ECMO PaCO at 24 hours (H24 values allowed calculate relative (Rel Δ = [H24 –...
Abstract Introduction Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with invasiveness. The present study aims to evaluate diagnostic yield of in critically ill patients hospitalized pediatric intensive care unit (ICU). Material and Methods Children who underwent a ICU between 1995 2022 were included. Biopsies performed operating room post‐mortem biopsies excluded. Results Thirty‐one included, median...
Acute bronchiolitis, a viral seasonal infection of the lower respiratory tract, affects nearly 20% all children and leads to hospitalization 2% 3% younger than 12 months every year.1,2 Approximately 6% hospitalized require admission PICU.1 bronchiolitis may account for as much 13% PICU admissions,3 it is responsible death ∼3 100 000 under each year4 (eg, 20 infants annually in England4 United States,5 respectively). Bronchiolitis epidemic has predictable pattern, France, starts September,...